DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stat92E and Stat5b

DIOPT Version :9

Sequence 1:	NP_001262760.1	Gene:	Stat92E / 42428	FlyBaseID:	FBgn0016917	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001107035.1	Gene:	Stat5b / 20851	MGIID:	103035	Length:	786	Species:	Mus musculus

Alignment Length:	865	Identity:	277/865 - (32%)
Similarity:	412/865 - (47%)	Gaps:	169/865 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLWKRISS-HVDCEQRMAAYYEEKGMLELRLCLAPWIEDRIMSEQITPNTTDQLERVALKFNED 64
            |::|.:... ..|...:|.|.|.:...:|:|..|:.|||.:........|..:.::  |.:..|.
Mouse     1 MAMWIQAQQLQGDALHQMQALYGQHFPIEVRHYLSQWIESQAWDSIDLDNPQENIK--ATQLLEG 63

  Fly    65 LQQKLLSTRTASDQA------LKFRVVELCALIQRI---SAVELYTHLRSGLQKELQLVTE---- 116
            |.|:|  .:.|..|.      ||.::......:|..   ..:||...:|..|..|.:||.|
Mouse    64 LVQEL--QKKAEHQVGEDGFLLKIKLGHYATQLQSTYDRCPMELVRCIRHILYNEQRLVREANNG 126

  Fly   117 KSVAATAGQSMPLNPYNMNNTPMVTGYMVDPSDLLAVSNSCNPPVVQGIGPIHNVQNTGIASPAL 181
            .|.|.:...:|......:|.|         ..:|..::....       ..:..:|.|
Mouse   127 SSPAGSLADAMSQKHLQINQT---------FEELRLITQDTE-------NELKKLQQT------- 168

  Fly   182 GMVTPKVELYEVQHQIMQSLNEFGNCANALKLLAQNYSYM--LNSTSSPNAEAA----------- 233
                  .|.:.:|:|            .:|::.|| ::.:  ||.....:.|.|
Mouse   169 ------QEYFIIQYQ------------ESLRIQAQ-FAQLGQLNPQERMSRETALQQKQVSLETW 214

  Fly   234 ----------YRSLIDEKAAIVLTMRRSFMYYESLHEMVI--HELKNWRHQQAQAGNGAPFNEGS 286
                      ||..:.||....|.:.|.       .:.:|  .||..|:.:|..||||.| .|||
Mouse   215 LQREAQTLQQYRVELAEKHQKTLQLLRK-------QQTIILDDELIQWKRRQQLAGNGGP-PEGS 271

  Fly   287 LDDIQRCFEMLESFI----------AHML------AAVKELMRVRLVTEEPELTHLLEQVQNAQK 335
            ||.:|...|.|...|          .|:.      ..|:|::        .|:...:..:.:|
Mouse   272 LDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEML--------AEVNATITDIISA-- 326

  Fly   336 NLVCSAFIVDKQPPQVMKTNTRFAASVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFV-TRNTQM 399
             ||.|.||::||||||:||.|:|||:||.|:|.:|.:|.|||.|:..|:||.|::..: ..||:.
Mouse   327 -LVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRN 390

  Fly   400 DNSSLSGQSSGEIQNASSTMEYQQNNHVFSASFRNMQLKKIKRAEKKGTESVMDEKFALFFYTTT 464
            |       .||||.|....|||.|.....||.||||.||:|||::::|.|||.:|||.:.|.:..
Mouse   391 D-------YSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRSDRRGAESVTEEKFTILFDSQF 448

  Fly   465 TV--NDFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDPFMITDRVTWAQLSVALNI 527
            :|  |:...:|.||||||||||||:|:..:.||:.|||||||..|.||.:.|:|.|.||..|||:
Mouse   449 SVGGNELVFQVKTLSLPVVVIVHGSQDNNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNM 513

  Fly   528 KFGS--CTGRSLTIDNLDFLYEKL-------QREERSEYITWNQFCKEPMPDRSFTFWEWFFAIM 583
            ||.:  .:.|.||.:||.||.:||       ..:..|..::|:||.:|.:|.|::|||:||..:|
Mouse   514 KFKAEVQSNRGLTKENLVFLAQKLFNISSNHLEDYNSMSVSWSQFNRENLPGRNYTFWQWFDGVM 578

  Fly   584 KLTKDHMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSDSELGGVTIA--YVNENGLVT 646
            ::.|.|:...|..|.|:||:||.:|. |||.:... |||||||||||:||:|||  :.::..:..
Mouse   579 EVLKKHLKPHWNDGAILGFVNKQQAH-DLLINKPD-GTFLLRFSDSEIGGITIAWKFDSQERMFW 641

  Fly   647 MLAPWTARDFQVLNLADRIRDLDVLCWLHPSDRNASPVKRDVAFGEFYSKRQEP---EPLVLDPV 708
            .|.|:|.|||.:.:||||:.||:.|.::.| ||     .:|    |.|||...|   ||......
Mouse   642 NLMPFTTRDFSIRSLADRLGDLNYLIYVFP-DR-----PKD----EVYSKYYTPVPCEPATAKAA 696

  Fly   709 TGYVKSTLHVHVCRNGENGST---SGTPHHAQESMQLGNISPQSGITFYSP---ARLE-ESDSDA 766
            .||||..:. .|.....|.||   ||..:..|....:  :.||:....|.|   :.|: :.|.|.
Mouse   697 DGYVKPQIK-QVVPEFANASTDAGSGATYMDQAPSPV--VCPQAHYNMYPPNPDSVLDTDGDFDL 758

  Fly   767 SETAEALERI--VIGAQPND 784
            .:|.:...|:  ::| :|.|
Mouse   759 EDTMDVARRVEELLG-RPMD 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	30/130 (23%)
		STAT_alpha	151..340	CDD:279369	44/229 (19%)
		STAT_bind	342..587	CDD:280939	119/256 (46%)
		SH2_STAT_family	578..696	CDD:198175	51/119 (43%)
Stat5b	NP_001107035.1	STAT_int	2..124	CDD:308484	30/125 (24%)
		STAT_alpha	141..330	CDD:307245	47/249 (19%)
		STAT_bind	332..582	CDD:308483	119/256 (46%)
		SH2_STAT5b	573..717	CDD:198283	63/156 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836461
Domainoid	1	1.000	124	1.000	Domainoid score	I5503
eggNOG	1	0.900	-	-		E1_KOG3667
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	317	1.000	Inparanoid score	I2525
Isobase	1	0.950	-	0	Normalized mean entropy	S6183
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166575at33208
OrthoFinder	1	1.000	-	-		FOG0001643
OrthoInspector	1	1.000	-	-		otm42868
orthoMCL	1	0.900	-	-		OOG6_104819
Panther	1	1.100	-	-	LDO	PTHR11801
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2821
SonicParanoid	1	1.000	-	-		X1200
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.740