Protein Alignment Stat92E and Stat5a

DIOPT Version :9

• Sequence 1: NP_001262760.1
• Gene: Stat92E / 42428
• FlyBaseID: FBgn0016917
• Length: 818
• Species: Drosophila melanogaster
• Sequence 2: NP_001157534.1
• Gene: Stat5a / 20850
• MGIID: 103036
• Length: 797
• Species: Mus musculus
• Alignment Length: 783
• Identity: 252/783 - (32%)
• Similarity: 362/783 - (46%)
• Gaps: 189/783 - (24%)

  Fly    12 DCEQRMAAYYEEKGMLELRLCLAPWIEDRIMSEQITPNTTDQLERVALKFNEDLQQKLLSTRTAS 76
            |..::|...|.:...:|:|..||.|||.:........|..|:.:  |.:..|.|.|:|  .:.|.
Mouse    13 DALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRGQ--ATQLLEGLVQEL--QKKAE 73

  Fly    77 DQA------LKFRVVELCALIQRI---SAVELYTHLRSGLQKELQLVTEKSVAATAGQSMPLNPY 132
            .|.      ||.::......:|..   ..:||...:|..|..|.:||.|
Mouse    74 HQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVRE---------------- 122

  Fly   133 NMNNTPMVTGYMVDPSDLLAVSNSCNPPVVQGIGPIHNVQNTGIASPALGMVTPKVELYEVQH-Q 196
                                 :|:|:.|             .|:...|:..          :| |
Mouse   123 ---------------------ANNCSSP-------------AGVLVDAMSQ----------KHLQ 143

  Fly   197 IMQSLNEF----GNCANALKLLAQNYSY-------------------MLNSTSSPNAEAA----- 233
            |.|...|.    .:..|.||.|.|...|                   .||.....:.|.|
Mouse   144 INQRFEELRLITQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLGQLNPQERMSRETALQQKQ 208

  Fly   234 ----------------YRSLIDEKAAIVLTMRRSFMYYESLHEMVI--HELKNWRHQQAQAGNGA 280
                            ||..:.||....|.:.|.       .:.:|  .||..|:.:|..||||.
Mouse   209 VSLETWLQREAQTLQQYRVELAEKHQKTLQLLRK-------QQTIILDDELIQWKRRQQLAGNGG 266

  Fly   281 PFNEGSLDDIQRCFEMLESFI----------AHML------AAVKELMRVRLVTEEPELTHLLEQ 329
            | .|||||.:|...|.|...|          .|:.      ..|:|::        .|:...:..
Mouse   267 P-PEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEML--------AEVNATITD 322

  Fly   330 VQNAQKNLVCSAFIVDKQPPQVMKTNTRFAASVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFVT 394
            :.:|   ||.|.||::||||||:||.|:|||:||.|:|.:|.:|.|||.|:..|:||.|::
Mouse   323 IISA---LVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAK---- 380

  Fly   395 RNTQMDNSSLSGQSSGEIQNASSTMEYQQNNHVFSASFRNMQLKKIKRAEKKGTESVMDEKFALF 459
              :.:.|.:...:.||||.|....|||.|.....||.||||.||:||||:::|.|||.:|||.:.
Mouse   381 --SLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVL 443

  Fly   460 FYTTTTV--NDFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDPFMITDRVTWAQLS 522
            |.:..:|  |:...:|.||||||||||||:|:..:.||:.|||||||..|.||.:.|:|.|.||.
Mouse   444 FESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQLC 508

  Fly   523 VALNIKFGS--CTGRSLTIDNLDFLYEKL-------QREERSEYITWNQFCKEPMPDRSFTFWEW 578
            .|||:||.:  .:.|.||.:||.||.:||       ..:..|..::|:||.:|.:|..::|||:|
Mouse   509 EALNMKFKAEVQSNRGLTKENLVFLAQKLFNISSNHLEDYNSMSVSWSQFNRENLPGWNYTFWQW 573

  Fly   579 FFAIMKLTKDHMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSDSELGGVTIA--YVNE 641
            |..:|::.|.|....|..|.|:||:||.:|. |||.:... |||||||||||:||:|||  :.:.
Mouse   574 FDGVMEVLKKHHKPHWNDGAILGFVNKQQAH-DLLINKPD-GTFLLRFSDSEIGGITIAWKFDSP 636

  Fly   642 NGLVTMLAPWTARDFQVLNLADRIRDLDVLCWLHPSDRNASPVKRDVAFGEFYS-------KRQE 699
            :..:..|.|:|.|||.:.:||||:.||:.|.::.| ||     .:|..|.::|:       ..|.
Mouse   637 DRNLWNLKPFTTRDFSIRSLADRLGDLNYLIYVFP-DR-----PKDEVFAKYYTPVLGSSMHPQM 695

  Fly   700 PEP 702
            |||
Mouse   696 PEP 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	30/115 (26%)
		STAT_alpha	151..340	CDD:279369	52/251 (21%)
		STAT_bind	342..587	CDD:280939	117/255 (46%)
		SH2_STAT_family	578..696	CDD:198175	51/126 (40%)
Stat5a	NP_001157534.1	STAT_int	2..124	CDD:280940	30/151 (20%)
		STAT_alpha	141..330	CDD:279369	47/207 (23%)
		STAT_bind	332..582	CDD:280939	117/255 (46%)
		SH2_STAT5a	573..708	CDD:198284	55/134 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836463
Domainoid	1	1.000	124	1.000	Domainoid score	I5503
eggNOG	1	0.900	-	-		E1_KOG3667
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	317	1.000	Inparanoid score	I2525
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166575at33208
OrthoFinder	1	1.000	-	-		FOG0001643
OrthoInspector	1	1.000	-	-		otm42868
orthoMCL	1	0.900	-	-		OOG6_104819
Panther	1	1.100	-	-	O	PTHR11801
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2821
SonicParanoid	1	1.000	-	-		X1200
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790