DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stat92E and Stat4

DIOPT Version :9

Sequence 1:	NP_001262760.1	Gene:	Stat92E / 42428	FlyBaseID:	FBgn0016917	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_006495878.1	Gene:	Stat4 / 20849	MGIID:	103062	Length:	768	Species:	Mus musculus

Alignment Length:	811	Identity:	208/811 - (25%)
Similarity:	351/811 - (43%)	Gaps:	173/811 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LCLAP--------W--------IEDRIMSEQITPNTTDQLERVALKFNEDLQQKLLSTRTASDQA 79
            :||.|        |        ::..::..::...:...::.||.. ||.:...||..
Mouse    23 ICLLPGPIRSSVSWHFPSPPGNVKQLLLCREVNHFSKCSVKEVASN-NETMATILLQN------- 79

  Fly    80 LKFRVVELCALIQRISAVELYTHLRSGLQKELQLVTE-KSVAATAGQSMPLNPYNMNNTPMVTGY 143
               .:::|...:.|:|.           :|.|.|:.. |.:..........||  |:...:::..
Mouse    80 ---LLIQLDEQLGRVSK-----------EKNLLLIHNLKRIRKVLQGKFHGNP--MHVAVVISNC 128

  Fly   144 MVDPSDLLAVSNSCNPPVVQGIGPIH-NVQNTGIA------SPALGMVTPKVELYEVQHQIMQSL 201
            :.:...:||.:|.   |:.   ||:. ::|::.::      ...:..:...|::.|...:.::.|
Mouse   129 LREERRILAAANM---PIQ---GPLEKSLQSSSVSERQRNVEHKVSAIKNSVQMTEQDTKYLEDL 187

  Fly   202 -NEFGNCANALKLLAQ-------------NYSYMLNSTSSPNAEAAYR--SLIDEKAAIVLTMRR 250
             :||......::.:.|             ....||||......||..:  .:::|...:
Mouse   188 QDEFDYRYKTIQTMDQGDKNSILVNQEVLTLQEMLNSLDFKRKEALSKMTQIVNETDLL------ 246

  Fly   251 SFMYYESLHEMVIHELKNWRHQQAQAGNGAPFNEGSLDDIQRCFEMLESFIAHMLAAVKELMR-- 313
                   ::.|::.||::|:.:|..|..|.|.:.| ||.:|.||.:|...:..:...:::|..
Mouse   247 -------MNSMLLEELQDWKKRQQIACIGGPLHNG-LDQLQNCFTLLAESLFQLRQQLEKLQEQS 303

  Fly   314 VRLVTE-EP---ELTHLLEQVQNAQKNLVCSAFIVDKQP--------PQVMKTNTRFAASVRWLI 366
            .::..| :|   :..||||:......||..::|:|::||        |.|:||..:|...:|.||
Mouse   304 TKMTYEGDPIPAQRAHLLERATFLIYNLFKNSFVVERQPCMPTHPQRPMVLKTLIQFTVKLRLLI 368

  Fly   367 GSQLGIHNNPPTVECII---MSEIQSQRFVTRNTQMDNSSLSGQSSGEIQNASSTMEYQQNNHVF 428
              :|...|....|:..|   :|.:.::|||...|.     :...||.|..|.|.::|
Mouse   369 --KLPELNYQVKVKASIDKNVSTLSNRRFVLCGTH-----VKAMSSEESSNGSLSVE-------- 418

  Fly   429 SASFRNMQLKKIK-RAEKKGTES---VMDEKFALFFYTTTTVNDFQIRVWTLSLPVVVIVHGNQE 489
               ||::|.|::| ....||.|.   |.:|..::.|.|...:....|.:.|.|||||:|.:.:|.
Mouse   419 ---FRHLQPKEMKCSTGSKGNEGCHMVTEELHSITFETQICLYGLTINLETSSLPVVMISNVSQL 480

  Fly   490 PQSWATITWDNAFAEIVRDPFMITD--RVTWAQLSVALNIKFGSCTGRSLTIDNLDFLYEKL--Q 550
            |.:||:|.|.|......::.....:  .||..||...::.:|.|..||.|..:.|:.|.|||  |
Mouse   481 PNAWASIIWYNVSTNDSQNLVFFNNPPSVTLGQLLEVMSWQFSSYVGRGLNSEQLNMLAEKLTVQ 545

  Fly   551 REERSEYITWNQFCKEPMPDRSFTFWEWFFAIMKLTKDHMLGMWKAGCIMGFINKTKAQTDLLRS 615
            ......::||.:||||.:|.::||||.|..||:.|.|.|:|.:|..|.||||::|.|.:  ||..
Mouse   546 SNYNDGHLTWAKFCKEHLPGKTFTFWTWLEAILDLIKKHILPLWIDGYIMGFVSKEKER--LLLK 608

  Fly   616 VYGIGTFLLRFSDSELGGVTIAYV--NENGLVTM--LAPWTARDFQVLNLADRIRDLDV------ 670
            ....||||||||:|.|||:|..:|  :|||.|..  :.|:.......|..||.:||..|
Mouse   609 DKMPGTFLLRFSESHLGGITFTWVDQSENGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENI 673

  Fly   671 ----LCWLHPSDRNASPVKRDVAFGEFYSKRQEPEPLVLDPVT-----GYVKST-LHVHVCRNGE 725
                |.:|:|.      :.:|.|||:.||.    :|..:...|     |||.|. :.:...|
Mouse   674 PENPLKYLYPD------IPKDKAFGKHYSS----QPCEVSRPTERGDKGYVPSVFIPISTIR--- 725

  Fly   726 NGSTSGTPHHAQESMQLG---------NISP 747
              |.|..|....:.:.:.         |:||
Mouse   726 --SDSTEPQSPSDLLPMSPSAYAVLRENLSP 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	17/104 (16%)
		STAT_alpha	151..340	CDD:279369	44/217 (20%)
		STAT_bind	342..587	CDD:280939	84/263 (32%)
		SH2_STAT_family	578..696	CDD:198175	50/131 (38%)
Stat4	XP_006495878.1	STAT_int	<64..141	CDD:383455	18/100 (18%)
		STAT4_CCD	160..332	CDD:341079	36/185 (19%)
		STAT4_DBD	336..493	CDD:341086	54/174 (31%)
		SH2_STAT4	573..720	CDD:198238	57/158 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	42	1.000	Domainoid score	I12365
eggNOG	1	0.900	-	-		E1_KOG3667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166575at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11801
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920