DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stat92E and Stat2

DIOPT Version :9

Sequence 1:	NP_001262760.1	Gene:	Stat92E / 42428	FlyBaseID:	FBgn0016917	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_064347.1	Gene:	Stat2 / 20847	MGIID:	103039	Length:	922	Species:	Mus musculus

Alignment Length:	879	Identity:	189/879 - (21%)
Similarity:	341/879 - (38%)	Gaps:	204/879 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLWKRISS--HVDCEQRMAAYYEEKGMLELRLCLAPWIEDRIMSEQITPNTTDQLERVALKFNE 63
            |:.|:.:.:  .:..:|....|.:....:::|..||.||||                       :
Mouse     1 MAQWEMLQNLDSLFLDQLHQVYSQSILPMDVRQHLATWIED-----------------------Q 42

  Fly    64 DLQQKLLSTRTASDQALKFRVVELCALIQRISAVELYTHLRSGLQKELQLVTEKSVAATAGQSMP 128
            :.::..|.:..|....|.|.:::........|:...:..|:..|:|..:.:          |:.|
Mouse    43 NWREAALGSDDAKANMLYFSILDQLNQWDHYSSDSNHFLLQHNLRKFSRDI----------QTFP 97

  Fly   129 LNPYNMNNTPMVTGYMVDPSDLL---AVSNSCNPPVVQGIGPIHNVQNTGIASPALGMVTPKVEL 190
            ..|..:  ..|:...:::...:|   ..:....||                  ||...|....:|
Mouse    98 NGPTQL--AEMIFNLLLEEQRILNQAQRAQEVQPP------------------PAPEAVVESQQL 142

  Fly   191 YEVQHQI----------MQSLNEFGNCANALKLLAQNYSYMLNSTSSPNAEAAYRSLIDEKAAIV 245
             |::::|          ::|:.:..:..:........:|....|:|.|: ::....|:...|..|
Mouse   143 -EIENRIQGLHVDIEFLVRSIRQLKDEQDVFSFRYTVFSLKKTSSSDPH-QSQQAQLVQATANKV 205

  Fly   246 LTMRRSFM--------YYESLHEMVIHELKNWRHQQAQAGNGAPFNEGSLDDIQRCFEMLESFIA 302
            ..||:..:        ...:|.::::.:|..|:.||.::..|||..|..|:.:::.......|:.
Mouse   206 DRMRKEVLDISKGLVGRLTTLVDLLLPKLDEWKVQQQKSCIGAPPPELQLEQLEQWLTAGAKFLF 270

  Fly   303 HMLAAVKELMRVRLVTEEPELTHLLE----------QVQNAQ-----KNLVCSAFIVDKQP---- 348
            |:...:|:|         .|::|:|.          .:||||     :.|:..:|:|:.||
Mouse   271 HLRQLLKQL---------KEMSHMLRYKGDMFGQGVDLQNAQVMELLQRLLQRSFVVETQPCMPQ 326

  Fly   349 ----PQVMKTNTRFAASVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFVTRNTQMDNSSLSGQSS 409
                |.::||..:|....|.|:..|.|..:        :.:|:...|         ||.|.|...
Mouse   327 TLHRPLILKTGNKFTVRTRLLVRLQEGSES--------LKAEVSVDR---------NSDLPGFRK 374

  Fly   410 GEI----QNASSTMEYQQNNHVFSASFRNMQLKKIKRAEK--KGTESVMDEKFALFFYTTTTVND 468
            ..|    |...:..|.|:...::...|..:..::...|.|  ||..:|.:|...:.|........
Mouse   375 FNILTSNQKTLTPEEGQRQGLIWDFGFLTLVEQRAVGAGKGNKGPLAVTEELHVISFVVEYVYQG 439

  Fly   469 FQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDP--FMITDRVTWAQLSVALNIKFGS 531
            .::::.|.:||||:|.:.||...:||:|.|.|..:...::.  |....:..|:.|...|:.:|.|
Mouse   440 LKMKLQTDTLPVVIISNMNQLSIAWASILWFNMLSPNPKNQQFFCQAPKAPWSLLGPVLSWQFSS 504

  Fly   532 CTGRSLTIDNLDFLYEKL---QREERSEYITWNQFCKEPMPDRSFTFWEWFFAIMKLTKDHMLGM 593
            ..||.|..:.|..|..||   ..:.....::|..|||...|.....||.|...|::|..||:..:
Mouse   505 YVGRGLDSEQLGMLRTKLFGKSCKMEDALLSWVDFCKRESPPGKIPFWTWLDKILELVHDHLKDL 569

  Fly   594 WKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSDSELGGVTIAYV----NENGLVTMLAPWTAR 654
            ||.|.||||:::.: :..||:.:.. ||||||||::..||:|.::|    ::...:..:.|:|..
Mouse   570 WKDGRIMGFVSRNQ-ERRLLKKMLS-GTFLLRFSETSEGGITCSWVEHQDDDKVEIYSVQPYTKE 632

  Fly   655 DFQVLNLADRIRDLDVLC----------WLHPSDRNASPVKRDVAFGEFYSKRQEPEPLVLDPVT 709
            ..|.|.|.:.||...||.          :|:|.      :.||.|||.:|.     |.:..:...
Mouse   633 VLQSLPLTEIIRHYQVLAEENIPENPLRFLYPR------IPRDEAFGCYYQ-----EKVNFEEQR 686

  Fly   710 GYVKSTLHVHVCRNGENGSTSGTPHHAQESMQLGNISPQSGITFYSPARLEESDSDASETAEAL- 773
            .|:|..|.|                          ||.:.......|..|::........||.|
Mouse   687 KYLKHKLIV--------------------------ISNRQVDELQQPLELKQDSESLEVNAELLL 725

  Fly   774 -----------ERIVIGAQPN-DPVISEITDALL 795
                       ..:|:|.:.. ||::|.....||
Mouse   726 AHDQELPLMMQTGLVLGTELKVDPILSTAPQVLL 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	18/118 (15%)
		STAT_alpha	151..340	CDD:279369	41/224 (18%)
		STAT_bind	342..587	CDD:280939	66/263 (25%)
		SH2_STAT_family	578..696	CDD:198175	43/131 (33%)
Stat2	NP_064347.1	STAT_int	2..123	CDD:214942	23/155 (15%)
		STAT_alpha	141..314	CDD:279369	35/183 (19%)
		STAT_bind	316..563	CDD:280939	66/263 (25%)
		SH2_STAT2	554..704	CDD:198236	50/188 (27%)
		Trypan_PARP	<742..820	CDD:114603	6/18 (33%)
		STAT2_C	853..907	CDD:288998
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	42	1.000	Domainoid score	I12365
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166575at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11801
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020