DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stat92E and Stat1

DIOPT Version :9

Sequence 1:	NP_001262760.1	Gene:	Stat92E / 42428	FlyBaseID:	FBgn0016917	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001192242.1	Gene:	Stat1 / 20846	MGIID:	103063	Length:	755	Species:	Mus musculus

Alignment Length:	856	Identity:	215/856 - (25%)
Similarity:	358/856 - (41%)	Gaps:	196/856 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLWKRISSHVDCE--QRMAAYYEEKGMLELRLCLAPWIEDR-------------IMSEQITPNT 50
            ||.|..: ..:|.:  :::...|::...:|:|..||.|:|.:             |....:....
Mouse     1 MSQWFEL-QQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAAYDVSFATIRFHDLLSQL 64

  Fly    51 TDQLERVALKFNEDLQQKLLSTRTASDQALKFRVVELCALIQRISAVELYTHLRSGLQKELQLVT 115
            .||..|.:|:.|..||..:..::.......:...|::..:|        |..|     ||.:.:.
Mouse    65 DDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPVQMSMII--------YNCL-----KEERKIL 116

  Fly   116 EKSVAATAGQSMPLNPYNMNNTPMVTGYMVDPSDLLAVSNSCNPPVVQGIGPIHNVQNTGIASPA 180
            |.:......|                                     :|     |:|||
Mouse   117 ENAQRFNQAQ-------------------------------------EG-----NIQNT------ 133

  Fly   181 LGMVTPKVEL----YEVQHQIMQSLNEFGNCANALKLLAQNYSYMLNSTSSPNAEAAYRSLIDEK 241
             .|:..:.||    ..|:.|:|....|.    ..|:.|...|.:...::.:...||...:..|:|
Mouse   134 -VMLDKQKELDSKVRNVKDQVMCIEQEI----KTLEELQDEYDFKCKTSQNREGEANGVAKSDQK 193

  Fly   242 AAIVLTMRRSFMYYESLHEMVIH-------------------ELKNWRHQQAQAGNGAPFNEGSL 287
            ...:| :.:.|:..::..:.:||                   ||..|:.:|..|..|.|.| ..|
Mouse   194 QEQLL-LHKMFLMLDNKRKEIIHKIRELLNSIELTQNTLINDELVEWKRRQQSACIGGPPN-ACL 256

  Fly   288 DDIQRCFEMLESFIAHMLAAVKELMRV-RLVTEEPELTHLLEQVQNAQ-----KNLVCSAFIVDK 346
            |.:|..|.::...:..:...:|:|..: :..|.||:.....:||.:.:     :.|:.|:|:|::
Mouse   257 DQLQSWFTIVAETLQQIRQQLKKLEELEQKFTYEPDPITKNKQVLSDRTFLLFQQLIQSSFVVER 321

  Fly   347 QP--------PQVMKTNTRFAASVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFVTRNTQMDNSS 403
            ||        |.|:||..:|...:|.|:..|...:|        :..::...:.|.     :.::
Mouse   322 QPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYN--------LKVKVSFDKDVN-----EKNT 373

  Fly   404 LSGQSSGEIQNASS---TMEYQQNNHVFSASFRNMQLKKIKRAEKKGTES---VMDEKFALFFYT 462
            :.|.....|....:   .|| :..|...:|.||::|||:.|.|..:..|.   |.:|..:|.|.|
Mouse   374 VKGFRKFNILGTHTKVMNME-ESTNGSLAAEFRHLQLKEQKNAGNRTNEGPLIVTEELHSLSFET 437

  Fly   463 TT----TVNDFQIRV--WTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDP-----FMITDRV 516
            ..    .|.|.::.|  .|.|||||||.:.:|.|..||:|.|.|.   :|.:|     |:.....
Mouse   438 QLCQPGLVIDLEVFVPFQTTSLPVVVISNVSQLPSGWASILWYNM---LVTEPRNLSFFLNPPCA 499

  Fly   517 TWAQLSVALNIKFGSCTGRSLTIDNLDFLYEKLQREERSE--YITWNQFCKEPMPDRSFTFWEWF 579
            .|:|||..|:.:|.|.|.|.|..|.|..|.|||.......  .|.|.:||||.:.|::|:||.|.
Mouse   500 WWSQLSEVLSWQFSSVTKRGLNADQLSMLGEKLLGPNAGPDGLIPWTRFCKENINDKNFSFWPWI 564

  Fly   580 FAIMKLTKDHMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSDSEL-GGVTIAYV--NE 641
            ..|::|.|.|:|.:|..|||||||:|.:.:. ||:.... ||||||||:|.. |.:|..:|  ::
Mouse   565 DTILELIKKHLLCLWNDGCIMGFISKERERA-LLKDQQP-GTFLLRFSESSREGAITFTWVERSQ 627

  Fly   642 NG---LVTMLAPWTARDFQVLNLADRIRDLDVLC----------WLHPSDRNASPVKRDVAFGEF 693
            ||   ....:.|:|.::...:...|.||:..|:.          :|:|:      :.:|.|||::
Mouse   628 NGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPN------IDKDHAFGKY 686

  Fly   694 YSKRQE-PEPLVLDPV--TGYVKSTLHVHVCRNGENGSTSGTPHHAQESMQLGNISPQSGITFYS 755
            ||:.:| |||:.||..  |||:|:.|            .|.:..|........|:.|.|...|..
Mouse   687 YSRPKEAPEPMELDDPKRTGYIKTEL------------ISVSEVHPSRLQTTDNLLPMSPEEFDE 739

  Fly   756 PARLEESDSDA 766
            .:|:...:.|:
Mouse   740 MSRIVGPEFDS 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	25/131 (19%)
		STAT_alpha	151..340	CDD:279369	43/217 (20%)
		STAT_bind	342..587	CDD:280939	83/271 (31%)
		SH2_STAT_family	578..696	CDD:198175	44/133 (33%)
Stat1	NP_001192242.1	STAT_int	2..121	CDD:214942	25/132 (19%)
		STAT_alpha	139..315	CDD:279369	37/181 (20%)
		STAT_bind	317..572	CDD:280939	83/271 (31%)
		SH2_STAT1	563..713	CDD:198235	56/169 (33%)
		STAT1_TAZ2bind	721..745	CDD:288974	5/23 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	42	1.000	Domainoid score	I12365
eggNOG	1	0.900	-	-		E1_KOG3667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11801
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910