DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stat92E and STAT_ANOGA

DIOPT Version :9

Sequence 1:	NP_001262760.1	Gene:	Stat92E / 42428	FlyBaseID:	FBgn0016917	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_311525.1	Gene:	STAT_ANOGA / 1272625	VectorBaseID:	AGAP010423	Length:	722	Species:	Anopheles gambiae

Alignment Length:	765	Identity:	230/765 - (30%)
Similarity:	364/765 - (47%)	Gaps:	154/765 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LRLCLAPWIEDRI-MSEQITPNTTDQLERVALKF-------------NEDLQQKLLSTRTA---S 76
            :|..|..||:|.: .:...|.|.....|..|.||             |...::|.|..|:|   .
Mosquito    28 IRQHLGNWIKDSLHNAPTYTNNMQSMYELDAAKFFTALVNEVDQVSANLPNKRKCLLCRSAIMLR 92

  Fly    77 DQALKFRVVELCALIQRISAVELYTHLRSGLQK--ELQLVTEKSVAATAGQSMPLNPYNMNNTPM 139
            ||..:             :..:||..|...:|.  |....||.::|.|:..
Mosquito    93 DQNFQ-------------NLTQLYLTLLHQIQPNCEKGCKTEYTIAQTSSD-------------- 130

  Fly   140 VTGYMVDPSDLLAVSNSCNPPVVQGIGPIHNVQNTGIASPALGMVTPKVELYEVQHQIMQSLNEF 204
              |...|              |:.|:..:|.::...               ::...|::|...
Mosquito   131 --GQQTD--------------VLYGLQQLHVMERNN---------------WKETQQLIQECE-- 162

  Fly   205 GNCANALKLLAQNYSYMLNSTSSPNA-----EAAYRSLIDEKAAIVLTMRRSFMYYESLHEMVIH 264
                       |::...|::..|.|.     ....|||:|   |...|:|::......::...|.
Mosquito   163 -----------QDHVQRLSNQRSHNKRIQCYSLKQRSLVD---AFQKTIRKAEEVLNLVYNKYIF 213

  Fly   265 ELKNWRHQQAQAGNGAPF------NEGSLDDIQRCFEMLESFIAHMLAAVKELMRVRL---VTEE 320
            |   |:..|.       |      |..|||:||..:|.|.:.:.:....:...|:.:|   |::|
Mosquito   214 E---WQKTQM-------FPEVRSTNAYSLDEIQTWYESLAAIMWNTKDQIHLTMKSQLREHVSQE 268

  Fly   321 --PELTHLLEQVQNAQKNLVCSAFIVDKQPPQVMKTNTRFAASVRWLIGSQLGIHNNPPTVECII 383
              .:|..:::.|::..|.|:..||||:.|||||||.||||.|:||.||.:.|.:....|.|...|
Mosquito   269 INSDLWKVMKDVKDFIKLLLHKAFIVENQPPQVMKMNTRFCATVRLLIDNALIMKIGNPKVTVSI 333

  Fly   384 MSEIQSQRFVTRNTQMDNSSLSGQSSGEIQNASSTMEYQQNNHVFSASFRNMQLKKIKRAEKKGT 448
            :||.|:|:..:.|...|      .|:|||:|....::||.:|. |.|:|.||:||||.|..:|..
Mosquito   334 ISETQAQQIQSTNAAAD------FSAGEIENNIGNLQYQLSNK-FLANFSNMRLKKINRGNRKLN 391

  Fly   449 ESVMDEKFALFFYTTTTV--NDFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDPFM 511
            :.|:||||||.|.::.|:  .:..:.|||||||.|||||.|||..:|.||.|||..|:..|..|.
Mosquito   392 KLVVDEKFALLFQSSFTLEQEELTVTVWTLSLPAVVIVHVNQEQLAWTTIIWDNLCAKADRKLFE 456

  Fly   512 ITDRVTWAQLSVALNIKFGSCTGRSLTIDNLDFLYEKLQREERS------EYITWNQFCKEPMPD 570
            :.:.:.|.:|..|:::.|.:..||.||.:|:.::|.|..|::.|      :.|::.||||:..|:
Mosquito   457 VPNLIPWNRLVEAISMTFSARVGRGLTDENMQYMYRKAYRDKLSFSVSNDQMISFAQFCKDTTPE 521

  Fly   571 RSFTFWEWFFAIMKLTKDHMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSDSELGGVT 635
            .::|||||.:|.:|:.:||:..:|....|:|||:|:.|:..|.:.|  .|||||||:||.|||::
Mosquito   522 CNYTFWEWLYAALKIIRDHLQVLWVDNTIIGFIHKSTAEKYLAKCV--PGTFLLRFTDSVLGGIS 584

  Fly   636 IAYVNENG----LVTMLAPWTARDFQVLNLADRIRDLDVLCWLHPSDRNASPVKRDVAFGEFYSK 696
            ||:|:|:.    .|..:.|:||:|..|.:||:||.||..|.:|:|:      :.:..|||.:.:
Mosquito   585 IAWVHESNDGQRQVLHIQPFTAKDLVVRSLANRICDLGELTYLYPT------IPKQEAFGRYTA- 642

  Fly   697 RQEPEPLVLDPVT-GYVKSTLH-VHVCRNGENGSTSGTPHHAQESMQLGN 744
                 |.:..|.: .|:.:.:. |.:.....|.|:|.||:..|......|
Mosquito   643 -----PAIQKPRSKHYISAEMRTVLIFAPSSNQSSSSTPNAEQSPSTSSN 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	25/108 (23%)
		STAT_alpha	151..340	CDD:279369	37/204 (18%)
		STAT_bind	342..587	CDD:280939	107/252 (42%)
		SH2_STAT_family	578..696	CDD:198175	48/121 (40%)
STAT_ANOGA	XP_311525.1	STAT_int	4..>73	CDD:296012	11/44 (25%)
		STAT_alpha	135..>253	CDD:279369	30/172 (17%)
		STAT_bind	292..538	CDD:280939	107/252 (42%)
		SH2_STAT_family	529..643	CDD:198175	48/127 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	139	1.000	Domainoid score	I9797
eggNOG	1	0.900	-	-		E1_KOG3667
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	408	1.000	Inparanoid score	I3884
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166575at33208
OrthoFinder	1	1.000	-	-		FOG0001643
OrthoInspector	1	1.000	-	-		otm49976
Panther	1	1.100	-	-	O	PTHR11801
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1200
TreeFam	1	0.960	-	-
	11	10.930