DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stat92E and stat6

DIOPT Version :9

Sequence 1:	NP_001262760.1	Gene:	Stat92E / 42428	FlyBaseID:	FBgn0016917	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_002939755.1	Gene:	stat6 / 100485184	XenbaseID:	XB-GENE-484108	Length:	787	Species:	Xenopus tropicalis

Alignment Length:	679	Identity:	220/679 - (32%)
Similarity:	344/679 - (50%)	Gaps:	90/679 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 VELYTHLRSGLQKELQLVTEKSVAATAGQSMPLNPYNM----NNTPMVTGYMVDPSDLLAVSNSC 157
            :||.:.|...|.:||:.::..|     |.::.|...|:    ...|:.|  ::....||....|
Frog    53 LELASTLIQSLLEELRKISRNS-----GAAVHLVHQNIQRISKQDPVQT--VLQIKHLLEKEKS- 109

  Fly   158 NPPVVQGIGPIHNVQNTGIASPALGMVTPKVELYEVQHQIMQSLNEFGNCANALKLLAQNYSYML 222
               ||..:.|..||          .::..|.|: :...|||:           ||...|..:.:.
Frog   110 ---VVVNLFPRSNV----------SLIQKKEEM-QFNVQIMK-----------LKHKLQQVAMVQ 149

  Fly   223 NSTSSPNAEAAYRSLIDEKAAI----VLTMRRSFMYYESLHEMVIHELKNWRHQQAQAGNGAPFN 283
            .......|..::.:.:.:.|::    .:.::..|...||.....:..:..|:.||..|||||||:
Frog   150 QQLRDSKANMSFHNQMHDVASLHMQWEVLVKEYFQLLESAQTQALKRIGIWKRQQQLAGNGAPFD 214

  Fly   284 EGSLDDIQRCFEMLESFIAHMLAAVKELMRVRLVTEEPELTHLLEQVQNAQKNLVCSAFIVDKQP 348
            | :|..:|   |.:|:..| |...:..|::...:..|.....|.|.:..:.:.|:.|:.:|||||
Frog   215 E-NLIPLQ---ERMETIFA-MYQDIDRLVKDFSLMGEQVPPGLPENMNCSLRTLITSSLLVDKQP 274

  Fly   349 PQVMKTNTRFAASVRWLIGSQL--GIHNNPPTVECIIMSEIQSQRFVTRNTQMDNSSLSGQSSGE 411
            |||:||.::|.|||.:|:||:|  |. ...|.|...|::|.::|.....:|    |....:.:||
Frog   275 PQVLKTQSKFQASVNFLLGSRLLAGA-AKMPVVRATIITEKKAQELYLTST----SETWNEGAGE 334

  Fly   412 IQNASSTMEYQQNNHVFSASFRNMQLKKIKRAEKKGTESVMDEKFALFFYTTTTVNDFQ--IRVW 474
            |:|..|.:|...|:.:..|.|:||.||||||.|:||:|||.:||.|:.|.....:|...  ..:.
Frog   335 IENGKSVLEIAPNSKMCGAVFKNMLLKKIKRCERKGSESVTEEKCAVLFVAEFNLNSINTTFHIQ 399

  Fly   475 TLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDPFMITDRVTWAQLSVALNIKFGSCTG--RSL 537
            .|||||||||||||:..:.|||.|||||:|:.|.||.:.::|.|.::...||:||.|..|  :.|
Frog   400 ALSLPVVVIVHGNQDNNAKATILWDNAFSEVERRPFFVEEKVPWPKMCHTLNMKFVSEVGTKQEL 464

  Fly   538 TIDNLDFLYEKL-----QREERSEYITWNQFCKEPMPDRSFTFWEWFFAIMKLTKDHMLGMWKAG 597
            ..::..||.:|:     ..:.:...::|.||.|||:.:|:||||:||..::.|||..:...|...
Frog   465 QEEHFVFLAQKIFNDNSLSDNKDRMVSWTQFNKEPLRERNFTFWQWFDGVVDLTKKCLKDYWSDR 529

  Fly   598 CIMGFINKTKAQTDLLRSVYGIGTFLLRFSDSELGGVTIAYV--NENG--LVTMLAPWTARDFQV 658
            .|||||:|......|  |....|||||||||||:||:|||::  .|:|  .:..:.|:||:|..:
Frog   530 LIMGFISKQYVHNIL--STQPDGTFLLRFSDSEIGGITIAHILKREDGSAQIQNIQPFTAKDLNI 592

  Fly   659 LNLADRIRDLDVLCWLHPSDRNASPVKRDVAFGEFYSKRQEPEPLVLDPVTGYVKSTLHVHVCRN 723
            |:|.||:|||..|.:|:      |...:|..||..|||:....|      .||..:.:.:.|.
Frog   593 LSLGDRVRDLKQLKYLY------SNKPKDDVFGRHYSKKTSKTP------DGYTPTLITLKVA-- 643

  Fly   724 GENGSTSGTPHHAQESMQ-----LGNISP 747
               |..:..|.:.|.|.:     :.::||
Frog   644 ---GGDTANPANPQLSKEPTWPVMSSMSP 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	6/21 (29%)
		STAT_alpha	151..340	CDD:279369	42/192 (22%)
		STAT_bind	342..587	CDD:280939	105/255 (41%)
		SH2_STAT_family	578..696	CDD:198175	50/121 (41%)
stat6	XP_002939755.1	STAT_int	5..111	CDD:367221	15/68 (22%)
		STAT6_CCD	107..271	CDD:341081	42/194 (22%)
		STAT6_DBD	268..427	CDD:341088	73/163 (45%)
		SH2_STAT6	510..638	CDD:198240	55/141 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I6989
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	317	1.000	Inparanoid score	I2501
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166575at33208
OrthoFinder	1	1.000	-	-		FOG0001643
OrthoInspector	1	1.000	-	-		otm47984
Panther	1	1.100	-	-	O	PTHR11801
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1200
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.070