DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS9 and FEN2

DIOPT Version :9

Sequence 1:	NP_650889.1	Gene:	MFS9 / 42426	FlyBaseID:	FBgn0038799	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_009957.1	Gene:	FEN2 / 850394	SGDID:	S000000623	Length:	512	Species:	Saccharomyces cerevisiae

Alignment Length:	526	Identity:	107/526 - (20%)
Similarity:	165/526 - (31%)	Gaps:	190/526 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KNGKHLEQVHQNNNEITESEPLTWRFWRKQRYIVVLLAFF-----------------GFFNVYSL 55
            |..|.:.| |:...|...|:...     |:|.::..:..|                 ||.|.|
Yeast     3 KESKSITQ-HEVERESVSSKRAI-----KKRLLLFKIDLFVLSFVCLQYWINYVDRVGFTNAY-- 59

  Fly    56 RVNLSVAIVAMTENRTVFDADGNVSYQQDFPWDSKQKGLILSSFFYGYILTQFLGGYIGTKIGGN 120
                   |..|.|:..:...|..||.                        |.|:.|||...:..|
Yeast    60 -------ISGMKEDLKMVGNDLTVSN------------------------TVFMIGYIVGMVPNN 93

  Fly   121 IV--------------FGTGIGSTAILTLLTPMAASHSLEMFLFVRIIEGFFEGVTFPGIHAVWA 171
            ::              |..|     :|||  .|....|.:....:|..:..||..||.|.|.|..
Yeast    94 LMLLCVPPRIWLSFCTFAWG-----LLTL--GMYKVTSFKHICAIRFFQALFESCTFSGTHFVLG 151

  Fly   172 RWSPPLERSRMASIAFAGNYAGTVVAMPCSGFLATKY-----------GWESVFYVFGTIGVIWY 225
            .|... :...:.|..|.|  :|.|.:| .|||:.|..           ||..:|.:...|.:...
Yeast   152 SWYKE-DELPIRSAIFTG--SGLVGSM-FSGFMQTSIFTHLNGRNGLAGWRWLFIIDFCITLPIA 212

  Fly   226 ITWLVFVKAGPELDRFCSK----------EECDYIQKTIGYVGSKHVKHPWRAIFTSMPFYAIMA 280
            |...:|....|:.....||          :|..|.::.:          |.|...|.:.:..|..
Yeast   213 IYGFIFFPGLPDQTSAVSKFSMTRYIFNEQELHYARRRL----------PARDESTRLDWSTIPR 267

  Fly   281 SHFSENWGFYTLLTQLPSFLRDTLNFDLGKTGILSAVPYLAMGILLAVSGYLADWLQVKGIWTTT 345
            .....:|..::|:..|..   :.|.|                    |.:...|.|||.:. :|..
Yeast   268 VLKRWHWWMFSLVWVLGG---ENLGF--------------------ASNSTFALWLQNQK-YTLA 308

  Fly   346 QVRRNFNCGAFLAQTVFMMLTAYLLDPT-----W------SVVSLTIAV---------------- 383
            | |.|:..|.|....|..:.:|..:...     |      |:|.:.:||
Yeast   309 Q-RNNYPSGIFAVGIVSTLCSAVYMSKIPRARHWHVSVFISLVMVIVAVLIRADPLNPKVVFSAQ 372

  Fly   384 GLGAFAWSGFAV--------NHLDIAPQHASVLMGIGNTFATIPGIVSPLLTGYVVTNQTSDEWR 440
            .||..|::|.||        .|.|:  |..::::...|.|:   |.|:..             |.
Yeast   373 YLGGVAYAGQAVFFSWANIICHADL--QERAIVLASMNMFS---GAVNAW-------------WS 419

  Fly   441 IIFFIS 446
            |:||.|
Yeast   420 ILFFAS 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS9	NP_650889.1	2A0114euk	38..477	CDD:129972	100/496 (20%)
MFS9	NP_650889.1	MFS	42..460	CDD:119392	99/492 (20%)
FEN2	NP_009957.1	MFS_FEN2_like	32..450	CDD:340885	99/491 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2916
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030