DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS9 and slc17a5

DIOPT Version :9

Sequence 1:	NP_650889.1	Gene:	MFS9 / 42426	FlyBaseID:	FBgn0038799	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001070195.1	Gene:	slc17a5 / 767760	ZFINID:	ZDB-GENE-060929-1158	Length:	488	Species:	Danio rerio

Alignment Length:	489	Identity:	192/489 - (39%)
Similarity:	283/489 - (57%)	Gaps:	34/489 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TDLESPKNGKHLEQVHQNNNEITESEPLTWRFWRKQRYIVVLLAFFGFFNVYSLRVNLSVAIVAM 66
            :|.||..:.:.|  :.:.:.|..:..|..    ...||.:..|:.:|||..|:||||||||:|.|
Zfish     6 SDSESEDHAQPL--LRRKDTEDIQKAPAC----GSSRYGLAFLSCYGFFVAYALRVNLSVAMVDM 64

  Fly    67 TENRTVFDADGNVSYQQDFP------------WDSKQKGLILSSFFYGYILTQFLGGYIGTKIGG 119
            .:|.:..:...::....:.|            |:|:.:|.||.|||||||:||..|||:..|.|.
Zfish    65 LKNSSKANTSSSICPPHNIPVPKHNHTAMVYDWNSETQGWILGSFFYGYIITQIPGGYLARKYGA 129

  Fly   120 NIVFGTGIGSTAILTLLTPMAASHSLEMFLFVRIIEGFFEGVTFPGIHAVWARWSPPLERSRMAS 184
            ..:.|.||..|.|.|||||:||.......:.||::||..||||:|.:||:||.|:|||||||:.:
Zfish   130 KWLLGLGILCTVIFTLLTPLAADLGAGYLIAVRVLEGIGEGVTYPAMHAMWASWAPPLERSRLLT 194

  Fly   185 IAFAGNYAGTVVAMPCSGFLATKYGWESVFYVFGTIGVIWYITWLVFVKAGPELDRFCSKEECDY 249
            |::.|...|||||:|.||.:.....|..|||:||.:|::|:..|:.||...|...:..::.|..|
Zfish   195 ISYTGAQLGTVVALPLSGQICFYLDWTYVFYIFGAVGLLWFFLWICFVSNSPSSHKRITEAEKTY 259

  Fly   250 IQKTI--------GYVGSKHVKHPWRAIFTSMPFYAIMASHFSENWGFYTLLTQLPSFLRDTLNF 306
            |..::        .|:       ||.:||.|||.:||:.:|||.||.||||||.||:::.|.|.|
Zfish   260 IMSSLKNELSPTQDYI-------PWTSIFKSMPLWAIVVAHFSYNWTFYTLLTLLPTYMNDVLGF 317

  Fly   307 DLGKTGILSAVPYLAMGILLAVSGYLADWLQVKGIWTTTQVRRNFNCGAFLAQTVFMMLTAYL-L 370
            .:.:.|:|||:|||...:|..:.|.|||.|:.:.::.|..||:.|.........||::...|. .
Zfish   318 SIQQNGMLSALPYLGCWLLALLGGQLADLLRERFLFRTVIVRKAFTVVGMAGPAVFLVAAGYTGC 382

  Fly   371 DPTWSVVSLTIAVGLGAFAWSGFAVNHLDIAPQHASVLMGIGNTFATIPGIVSPLLTGYVVTNQT 435
            :...:|..|||:..||..:.|||.:|||||||.:|.:|:||.|:||||||:|.|::...:..:.|
Zfish   383 NYILAVAFLTISSSLGGISASGFNINHLDIAPSYAGILLGITNSFATIPGMVGPVIARSLTKSNT 447

  Fly   436 SDEWRIIFFISAGIYLVGCVIYWFYCSGDLQEWA 469
            ..||:|:|:|||.|.:.|.|.:..:..|.:|.||
Zfish   448 IPEWQIVFYISAAINIFGAVFFTIFGKGTVQPWA 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS9	NP_650889.1	2A0114euk	38..477	CDD:129972	186/453 (41%)
MFS9	NP_650889.1	MFS	42..460	CDD:119392	180/438 (41%)
slc17a5	NP_001070195.1	2A0114euk	27..488	CDD:129972	187/466 (40%)
slc17a5	NP_001070195.1	MFS	92..472	CDD:119392	163/386 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2916
SonicParanoid	1	1.000	-	-		X201
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.840