DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MFS9 and SLC17A7

DIOPT Version :9

Sequence 1:	NP_650889.1	Gene:	MFS9 / 42426	FlyBaseID:	FBgn0038799	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_064705.1	Gene:	SLC17A7 / 57030	HGNCID:	16704	Length:	560	Species:	Homo sapiens

Alignment Length:	526	Identity:	200/526 - (38%)
Similarity:	297/526 - (56%)	Gaps:	45/526 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GKHLEQVH------QNNNEITE----SEPLTWR-----------FWRKQRYIVVLLAFFGFFNVY 53
            |:.|.::|      |...|..|    ..|:|.:           |...:|||:.:::..||...:
Human    13 GRALGKLHRLLEKRQEGAETLELSADGRPVTTQTRDPPVVDCTCFGLPRRYIIAIMSGLGFCISF 77

  Fly    54 SLRVNLSVAIVAMTENRTVFDADGNVSYQQDFPWDSKQKGLILSSFFYGYILTQFLGGYIGTKIG 118
            .:|.||.||||:|..|.|.......|..:..|.||.:..|||..|||:|||:||..||:|..|..
Human    78 GIRCNLGVAIVSMVNNSTTHRGGHVVVQKAQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFA 142

  Fly   119 GNIVFGTGIGSTAILTLLTPMAASHSLEMFLFVRIIEGFFEGVTFPGIHAVWARWSPPLERSRMA 183
            .|.|||..|.:|:.|.:|.|.||.......:||||::|..||||:|..|.:|::|:|||||||:|
Human   143 ANRVFGFAIVATSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLA 207

  Fly   184 SIAFAGNYAGTVVAMPCSGFLATKYGWESVFYVFGTIGVIWYITWLVFVKAGPELDRFCSKEECD 248
            :.||.|:|||.|||||.:|.|....||.|||||:|:.|:.||:.||:.....|.|....|:||..
Human   208 TTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSISEEERK 272

  Fly   249 YIQKTIGYVGS-----KHVKHPWRAIFTSMPFYAIMASHFSENWGFYTLLTQLPSFLRDTLNFDL 308
            ||:..||....     .....|||..|||||.|||:.::|..:|.||.||...|::..:...|::
Human   273 YIEDAIGESAKLMNPLTKFSTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEI 337

  Fly   309 GKTGILSAVPYLAMGILLAVSGYLADWLQVKGIWTTTQVRRNFNCGAFLAQTVFMMLTAYLLDPT 373
            .|.|::||:|:|.|.|::.:.|.:||:|:.:.|.:||.||:..|||.|..:...:::..|.....
Human   338 SKVGLVSALPHLVMTIIVPIGGQIADFLRSRRIMSTTNVRKLMNCGGFGMEATLLLVVGYSHSKG 402

  Fly   374 WSVVSLTIAVGLGAFAWSGFAVNHLDIAPQHASVLMGIGNTFATIPGIVSPLLTGYVVTNQTSDE 438
            .::..|.:|||...||.|||.||||||||::||:||||.|...|:.|:|.|::.|.:..::|.:|
Human   403 VAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTREE 467

  Fly   439 WRIIFFISAGIYLVGCVIYWFYCSGDLQEWAKTPEQKAQEAEEKAQLQLTQTAGFV-------NS 496
            |:.:|.|::.::..|.:.|..:.||:.|.||: ||:.::|           ..|||       :.
Human   468 WQYVFLIASLVHYGGVIFYGVFASGEKQPWAE-PEEMSEE-----------KCGFVGHDQLAGSD 520

  Fly   497 GAELKD 502
            .:|::|
Human   521 DSEMED 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS9	NP_650889.1	2A0114euk	38..477	CDD:129972	185/443 (42%)
MFS9	NP_650889.1	MFS	42..460	CDD:119392	175/422 (41%)
SLC17A7	NP_064705.1	MFS_SLC17A6_7_8_VGluT	66..490	CDD:340940	175/423 (41%)
SLC17A7	NP_064705.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..560		10/42 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D144672at33208
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X201
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.720