DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS9 and slc17a8

DIOPT Version :9

Sequence 1:	NP_650889.1	Gene:	MFS9 / 42426	FlyBaseID:	FBgn0038799	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001076304.1	Gene:	slc17a8 / 563467	ZFINID:	ZDB-GENE-060503-416	Length:	590	Species:	Danio rerio

Alignment Length:	493	Identity:	198/493 - (40%)
Similarity:	294/493 - (59%)	Gaps:	20/493 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DLESPKNGKHLEQVHQNNNEITE----------SEPL--TWRFWRKQRYIVVLLAFFGFFNVYSL 55
            :|:...:|.::.:  ::|.|:||          |.||  ...|...:|||:.:|:..||...:.:
Zfish    30 NLQKKIDGSNVTE--EDNIELTEDGRPVAAPKRSPPLLDCGCFGLPKRYIIAMLSGLGFCISFGI 92

  Fly    56 RVNLSVAIVAMTENRTVFDADGNVSYQQDFPWDSKQKGLILSSFFYGYILTQFLGGYIGTKIGGN 120
            |.||.||||.|..|.||:.....|.....|.||.:..|||..|||:|||:||..||:|..|:..|
Zfish    93 RCNLGVAIVEMVNNNTVYINGTAVMQPAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKLAAN 157

  Fly   121 IVFGTGIGSTAILTLLTPMAASHSLEMFLFVRIIEGFFEGVTFPGIHAVWARWSPPLERSRMASI 185
            .|||..|..|::|.:..|.||.......:||||::|..||||:|..|.:|::|:|||||||:|:.
Zfish   158 RVFGAAIFLTSVLNMFIPSAARVHYGCVMFVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATT 222

  Fly   186 AFAGNYAGTVVAMPCSGFLATKYGWESVFYVFGTIGVIWYITWLVFVKAGPELDRFCSKEECDYI 250
            :|.|:|||.|:|||.:|.|....||.||||::|..|:||||.|::.....|.:....|:||.:||
Zfish   223 SFCGSYAGAVIAMPLAGILVQYVGWPSVFYIYGVFGIIWYIFWILLAYNSPAVHPTISEEERNYI 287

  Fly   251 QKTIG-----YVGSKHVKHPWRAIFTSMPFYAIMASHFSENWGFYTLLTQLPSFLRDTLNFDLGK 310
            :.:||     ...::..|.|||..|||||.|||:.::|..:|.||.||...|::..:...|.:.|
Zfish   288 ETSIGEGANLMSSTEKFKTPWREFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFPISK 352

  Fly   311 TGILSAVPYLAMGILLAVSGYLADWLQVKGIWTTTQVRRNFNCGAFLAQTVFMMLTAYLLDPTWS 375
            .|||||||::.|.|::.:.|.|||:|:.:.|.:||.||:..|||.|..:...:::..:......:
Zfish   353 VGILSAVPHMVMTIIVPIGGQLADFLRSRKILSTTTVRKIMNCGGFGMEATLLLVVGFSHTRAVA 417

  Fly   376 VVSLTIAVGLGAFAWSGFAVNHLDIAPQHASVLMGIGNTFATIPGIVSPLLTGYVVTNQTSDEWR 440
            :..|.:|||...||.|||.||||||||::||:||||.|...|:.|:|.||:.|.:..::|..||:
Zfish   418 ISFLILAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGALTKHKTRLEWQ 482

  Fly   441 IIFFISAGIYLVGCVIYWFYCSGDLQEWAKTPEQKAQE 478
            .:|.|::.::..|.:.|..:.||:.|:|| .||..:.|
Zfish   483 HVFVIASMVHYTGVIFYAIFASGEKQDWA-DPENTSDE 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS9	NP_650889.1	2A0114euk	38..477	CDD:129972	187/443 (42%)
MFS9	NP_650889.1	MFS	42..460	CDD:119392	177/422 (42%)
slc17a8	NP_001076304.1	2A0114euk	75..514	CDD:129972	185/439 (42%)
		MFS	81..503	CDD:119392	177/421 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..590
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D144672at33208
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X201
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.720