DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MFS9 and slc17a6a

DIOPT Version :9

Sequence 1:	NP_650889.1	Gene:	MFS9 / 42426	FlyBaseID:	FBgn0038799	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001009982.1	Gene:	slc17a6a / 494492	ZFINID:	ZDB-GENE-050105-4	Length:	587	Species:	Danio rerio

Alignment Length:	534	Identity:	204/534 - (38%)
Similarity:	303/534 - (56%)	Gaps:	43/534 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ESPKN--GKHLEQVH------QNNNEITE-------------SEPLT--WRFWRKQRYIVVLLAF 46
            |..:|  ||.|..:|      |...|:.|             ..||.  ..|...:|||:.:::.
Zfish    14 EKMRNLAGKTLGHMHRVMERKQKTGEVIELTEDGRPMHMPEKKAPLVDCTCFGLPRRYIIAIMSG 78

  Fly    47 FGFFNVYSLRVNLSVAIVAMTENRTVFDADGN--VSYQQDFPWDSKQKGLILSSFFYGYILTQFL 109
            .||...:.:|.||.||||.|..|.|:... |.  :..:..|.||.:..|:|..|||:||.:||..
Zfish    79 LGFCISFGIRCNLGVAIVDMVNNSTIHKG-GKIIIKGKAKFNWDPETVGMIHGSFFWGYTVTQIP 142

  Fly   110 GGYIGTKIGGNIVFGTGIGSTAILTLLTPMAASHSLEMFLFVRIIEGFFEGVTFPGIHAVWARWS 174
            ||||.:::..|.|||..|..|:.|.:..|.||.......:||||::|..||||:|..|.:|::|:
Zfish   143 GGYISSRLAANRVFGAAILLTSTLNMFIPSAARVHYGCVMFVRILQGLVEGVTYPACHGIWSKWA 207

  Fly   175 PPLERSRMASIAFAGNYAGTVVAMPCSGFLATKYGWESVFYVFGTIGVIWYITWLVFVKAGPELD 239
            |||||||:|:.:|.|:|||.|||||.:|.|....||.||||::|:.|::||:.|::.....|...
Zfish   208 PPLERSRLATTSFCGSYAGAVVAMPLAGILVQYSGWSSVFYIYGSFGIVWYMFWILVSYESPADH 272

  Fly   240 RFCSKEECDYIQKTIG----YVGS-KHVKHPWRAIFTSMPFYAIMASHFSENWGFYTLLTQLPSF 299
            ...:.||..||:::||    .:|: :..|.|||..|||||.|||:.::|..:|.||.||...|::
Zfish   273 PTITDEERTYIEESIGESAKLLGAMEKYKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAY 337

  Fly   300 LRDTLNFDLGKTGILSAVPYLAMGILLAVSGYLADWLQVKGIWTTTQVRRNFNCGAFLAQTVFMM 364
            ..:...|::.|.|::||:|:|.|.|::.:.|.|||:|:.|.|.|||.||:..|||.|..:...::
Zfish   338 FEEVFGFEISKVGMVSALPHLVMTIIVPIGGQLADYLRSKNILTTTTVRKIMNCGGFGMEATLLL 402

  Fly   365 LTAYLLDPTWSVVSLTIAVGLGAFAWSGFAVNHLDIAPQHASVLMGIGNTFATIPGIVSPLLTGY 429
            :..:......::..|.:|||...||.|||.||||||||::||:||||.|...|:.|:|.||:.|.
Zfish   403 VVGFSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGA 467

  Fly   430 VVTNQTSDEWRIIFFISAGIYLVGCVIYWFYCSGDLQEWAKTPEQKAQE----------AEEKAQ 484
            :..|:|.:||:.:|.|::.::..|.:.|..:.||:.|.|| .||:.:.|          |||...
Zfish   468 MTKNKTREEWQNVFLIASLVHYGGVIFYGIFASGEKQPWA-DPEETSDEKCGFIDEDELAEETGD 531

  Fly   485 LQLTQTAGFVNSGA 498
            :.|:. |.|...||
Zfish   532 ITLSH-APFGAQGA 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS9	NP_650889.1	2A0114euk	38..477	CDD:129972	183/445 (41%)
MFS9	NP_650889.1	MFS	42..460	CDD:119392	173/424 (41%)
slc17a6a	NP_001009982.1	2A0114euk	70..512	CDD:129972	183/443 (41%)
slc17a6a	NP_001009982.1	MFS	75..499	CDD:119392	173/424 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D144672at33208
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X201
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.720