DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MFS9 and SLC17A8

DIOPT Version :9

Sequence 1:	NP_650889.1	Gene:	MFS9 / 42426	FlyBaseID:	FBgn0038799	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_647480.1	Gene:	SLC17A8 / 246213	HGNCID:	20151	Length:	589	Species:	Homo sapiens

Alignment Length:	447	Identity:	189/447 - (42%)
Similarity:	271/447 - (60%)	Gaps:	7/447 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 QRYIVVLLAFFGFFNVYSLRVNLSVAIVAMTENRTVFDADGNVSYQ-QDFPWDSKQKGLILSSFF 100
            :|||:.:::..||...:.:|.||.||||.|..|.||: .||....| ..|.||.:..|||..|||
Human    74 KRYIIAIMSGLGFCISFGIRCNLGVAIVEMVNNSTVY-VDGKPEIQTAQFNWDPETVGLIHGSFF 137

  Fly   101 YGYILTQFLGGYIGTKIGGNIVFGTGIGSTAILTLLTPMAASHSLEMFLFVRIIEGFFEGVTFPG 165
            :|||:||..||:|..|...|.|||..|..|:.|.:..|.||.......:.|||::|..||||:|.
Human   138 WGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPA 202

  Fly   166 IHAVWARWSPPLERSRMASIAFAGNYAGTVVAMPCSGFLATKYGWESVFYVFGTIGVIWYITWLV 230
            .|.:|::|:|||||||:|:.:|.|:|||.|||||.:|.|....||.||||::|..|:|||:.||:
Human   203 CHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWSSVFYIYGMFGIIWYMFWLL 267

  Fly   231 FVKAGPELDRFCSKEECDYIQKTIG----YVGSKHVKHPWRAIFTSMPFYAIMASHFSENWGFYT 291
            .....|......|.||..||:.:||    .|.......||:..|||:|.|||:.::|..:|.||.
Human   268 QAYECPAAHPTISNEEKTYIETSIGEGANVVSLSKFSTPWKRFFTSLPVYAIIVANFCRSWTFYL 332

  Fly   292 LLTQLPSFLRDTLNFDLGKTGILSAVPYLAMGILLAVSGYLADWLQVKGIWTTTQVRRNFNCGAF 356
            ||...|::..:...|.:.|.|:|||||::.|.|::.:.|.|||:|:.:.|.|||.||:..|||.|
Human   333 LLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTTAVRKIMNCGGF 397

  Fly   357 LAQTVFMMLTAYLLDPTWSVVSLTIAVGLGAFAWSGFAVNHLDIAPQHASVLMGIGNTFATIPGI 421
            ..:...:::..:......::..|.:|||...||.|||.||||||||::||:||||.|...|:.|:
Human   398 GMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGM 462

  Fly   422 VSPLLTGYVVTNQTSDEWRIIFFISAGIYLVGCVIYWFYCSGDLQEWAKTPEQKAQE 478
            |.||:.|.:..::|.:||:.:|.|:|.::..|.:.|..:.||:.|||| .||..::|
Human   463 VCPLIVGAMTRHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQEWA-DPENLSEE 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS9	NP_650889.1	2A0114euk	38..477	CDD:129972	188/443 (42%)
MFS9	NP_650889.1	MFS	42..460	CDD:119392	177/422 (42%)
SLC17A8	NP_647480.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..61
		2A0114euk	75..513	CDD:129972	186/439 (42%)
		MFS	80..502	CDD:119392	177/422 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D144672at33208
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X201
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.720