DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS9 and slc17a6

DIOPT Version :9

Sequence 1:	NP_650889.1	Gene:	MFS9 / 42426	FlyBaseID:	FBgn0038799	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	XP_004913390.1	Gene:	slc17a6 / 101730310	XenbaseID:	XB-GENE-1011394	Length:	583	Species:	Xenopus tropicalis

Alignment Length:	497	Identity:	195/497 - (39%)
Similarity:	293/497 - (58%)	Gaps:	21/497 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KNGKHLEQVHQNNN-EITESEPLTWR---FWRKQRYIVVLLAFFGFFNVYSLRVNLSVAIVAMTE 68
            |.|:::|....... |:.|.:|....   |...:|||:.:::..||...:.:|.||.||||.|..
Frog    36 KTGENIELTEDGKPVEVAEKKPPLCDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVN 100

  Fly    69 NRTVFDADGNVSYQQDFPWDSKQKGLILSSFFYGYILTQFLGGYIGTKIGGNIVFGTGIGSTAIL 133
            |.|:......:..:..|.||.:..|:|..|||:|||:||..||||.:::..|.|||..|..|:.|
Frog   101 NSTIHHGGKIIKEKAKFNWDPEIVGMIHGSFFWGYIVTQIPGGYIASRLAANRVFGAAIVLTSTL 165

  Fly   134 TLLTPMAASHSLEMFLFVRIIEGFFEGVTFPGIHAVWARWSPPLERSRMASIAFAGNYAGTVVAM 198
            .:|.|.||.......:||||::|..||||:|..|.:|::|:|||||||:|:.:|.|:|||.|:||
Frog   166 NMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAM 230

  Fly   199 PCSGFLATKYGWESVFYVFGTIGVIWYITWLVFVKAGPELDRFCSKEECDYIQKTIGYVGS---- 259
            |.:|.|....||.|||||:|..|::||:.|::.....|......:.||.:||:::||...:
Frog   231 PLAGILVQYTGWSSVFYVYGCFGLVWYLFWILVSYESPAKHPTITDEERNYIEESIGESANILGP 295

  Fly   260 -KHVKHPWRAIFTSMPFYAIMASHFSENWGFYTLLTQLPSFLRDTLNFDLGKTGILSAVPYLAMG 323
             :..|.|||..|||||.|||:.::|..:|.||.||...|::..:...|::.|.|:|||||:|.|.
Frog   296 VEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMT 360

  Fly   324 ILLAVSGYLADWLQVKGIWTTTQVRRNFNCGAFLAQTVFMMLTAYLLDPTWSVVSLTIAVGLGAF 388
            |::.:.|.:||:|:.|.|.:||.||:..|||.|..:...:::..|......::..|.:|||...|
Frog   361 IIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGF 425

  Fly   389 AWSGFAVNHLDIAPQHASVLMGIGNTFATIPGIVSPLLTGYVVTNQTSDEWRIIFFISAGIYLVG 453
            |.|||.||||||||::||:||||.|...|:.|:|.||:.|.:..:::.:||:.:|.|:|.::..|
Frog   426 AISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKSREEWQYVFLIAALVHYGG 490

  Fly   454 CVIYWFYCSGDLQEWAKTPEQKAQEAEEKAQLQLTQTAGFVN 495
            .:.|..:.||:.|.|| .|||.:.|           ..||:|
Frog   491 VIFYGIFASGEKQPWA-DPEQTSDE-----------KCGFIN 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS9	NP_650889.1	2A0114euk	38..477	CDD:129972	184/443 (42%)
MFS9	NP_650889.1	MFS	42..460	CDD:119392	173/422 (41%)
slc17a6	XP_004913390.1	MFS_SLC17A6_7_8_VGluT	74..498	CDD:340940	173/423 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11242
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D144672at33208
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X201
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010