DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS9 and slc17a8

DIOPT Version :9

Sequence 1:	NP_650889.1	Gene:	MFS9 / 42426	FlyBaseID:	FBgn0038799	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	XP_002936892.1	Gene:	slc17a8 / 100489470	XenbaseID:	XB-GENE-988965	Length:	588	Species:	Xenopus tropicalis

Alignment Length:	495	Identity:	202/495 - (40%)
Similarity:	297/495 - (60%)	Gaps:	26/495 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DLESPKNGKHLEQVHQNNNEITE--------SEPLTWRF-----WRKQRYIVVLLAFFGFFNVYS 54
            :|:...:|:::|   ::|.|:.|        ::|.. ||     ...:|||:.:::..||...:.
Frog    31 NLQRKIDGRNIE---EDNIELDEDGRPVQAPTQPPP-RFDCYCCGIPKRYIIAMMSGLGFCISFG 91

  Fly    55 LRVNLSVAIVAMTENRTVFDADGNVSYQQ-DFPWDSKQKGLILSSFFYGYILTQFLGGYIGTKIG 118
            :|.||.||||.|..|.||: .||....|: .|.||.:..|||..|||:|||:||..||:|..|:.
Frog    92 IRCNLGVAIVEMVNNNTVY-VDGKPEMQKAQFNWDPETVGLIHGSFFWGYIITQIPGGFIANKLA 155

  Fly   119 GNIVFGTGIGSTAILTLLTPMAASHSLEMFLFVRIIEGFFEGVTFPGIHAVWARWSPPLERSRMA 183
            .|.|||..|..|:||.:|.|.||.......:.||:::|..||||:|..|.:|::|:|||||||:|
Frog   156 ANRVFGAAIFLTSILNMLIPSAARVHFGCVISVRVLQGLVEGVTYPACHGMWSKWAPPLERSRLA 220

  Fly   184 SIAFAGNYAGTVVAMPCSGFLATKYGWESVFYVFGTIGVIWYITWLVFVKAGPELDRFCSKEECD 248
            :.:|.|:|||.|:|||.:|.|....||.||||::|..|:.||:.||:.....|......:.||..
Frog   221 TTSFCGSYAGAVIAMPLAGVLVQYIGWPSVFYIYGVFGMCWYVFWLLHATESPAAHPSITFEERT 285

  Fly   249 YIQKTIGYVGSKHV-----KHPWRAIFTSMPFYAIMASHFSENWGFYTLLTQLPSFLRDTLNFDL 308
            ||:.:|| .||..|     |.||:..|||||.|||:.::|..:|.||.||...|::..:...|.:
Frog   286 YIETSIG-EGSNLVTTGKFKTPWKKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFPI 349

  Fly   309 GKTGILSAVPYLAMGILLAVSGYLADWLQVKGIWTTTQVRRNFNCGAFLAQTVFMMLTAYLLDPT 373
            .|.|:|||||::.|.|::.|.|.|||:|:.:.|.:||.||:..|||.|..:...:::..|.....
Frog   350 SKVGLLSAVPHMVMTIIVPVGGQLADFLRSRKILSTTTVRKIMNCGGFGMEATLLLVVGYSHTKA 414

  Fly   374 WSVVSLTIAVGLGAFAWSGFAVNHLDIAPQHASVLMGIGNTFATIPGIVSPLLTGYVVTNQTSDE 438
            .|:..|.:|||...||.|||.||||||||::||:||||.|...|:.|:|.||:.|.:..|:|.:|
Frog   415 ISISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKNKTREE 479

  Fly   439 WRIIFFISAGIYLVGCVIYWFYCSGDLQEWAKTPEQKAQE 478
            |:.:|.|:|.::..|.:.|..:.||:.|||| .||..:::
Frog   480 WQNVFLIAAIVHYSGVIFYGIFASGEKQEWA-DPESLSED 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS9	NP_650889.1	2A0114euk	38..477	CDD:129972	193/444 (43%)
MFS9	NP_650889.1	MFS	42..460	CDD:119392	182/423 (43%)
slc17a8	XP_002936892.1	2A0114euk	75..513	CDD:129972	191/440 (43%)
slc17a8	XP_002936892.1	MFS	81..502	CDD:119392	182/422 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11242
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D144672at33208
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X201
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.010