DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF3g2 and eif3g

DIOPT Version :9

Sequence 1:	NP_650887.1	Gene:	eIF3g2 / 42422	FlyBaseID:	FBgn0038796	Length:	273	Species:	Drosophila melanogaster
Sequence 2:	NP_957293.1	Gene:	eif3g / 393974	ZFINID:	ZDB-GENE-040426-1076	Length:	293	Species:	Danio rerio

Alignment Length:	280	Identity:	129/280 - (46%)
Similarity:	178/280 - (63%)	Gaps:	16/280 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SWADEVDADYVDG-LPPSNEYIKGDFKYVTEYKFNDDGKKVKVVRTFKIEKQIVPKAVARRRNWV 70
            ||||:|:.:..:| ||...|.:||:.|.|||||.:|||:|.|::||||||.:...||||||:||.
Zfish    12 SWADQVEEEGDEGSLPSPKETVKGNIKTVTEYKIDDDGQKFKIIRTFKIETRKASKAVARRKNWK 76

  Fly    71 KFGDSRSDKPGPNSQTTMASEEIFMQFIGSKDFDQTHETQLDP-----GKNIAKCRICNGEHWSV 130
            |||:|..|.||||..||..|:::||.||.||:.....:...||     |:.|..||||.|:||:.
Zfish    77 KFGNSEYDAPGPNVATTTVSDDVFMTFISSKEDLNAQDQDEDPMNKLEGQKIVSCRICKGDHWTT 141

  Fly   131 NCPYKGT--SMDSKTVMETKANAAAAAAISDP-------SKTGKYVPPFMKDGGGISGSKNWGRG 186
            .||||.|  .|..:...:...:.......::|       :||||||||.::|||...| ::....
Zfish   142 RCPYKDTLGPMQKELAEQLGLSTGEKEKAAEPEPAQPVQNKTGKYVPPSLRDGGTRRG-ESMQPN 205

  Fly   187 RDRDDSSAVRISNLSESMTETDLEELVKKIGPHTKMYLAREKNSGLCKGFAYVHFKFRQDAAAAI 251
            |..||::.:|::||||...||||:||.:..|..:::|||::||:|..||||.:.|..|:|||.||
Zfish   206 RRADDNATIRVTNLSEDTRETDLQELFRPFGSISRIYLAKDKNTGQSKGFALISFHRREDAARAI 270

  Fly   252 EVLNGHGYDHLILCVEWSKP 271
            ..::|.|||||||.|||:||
Zfish   271 AGVSGFGYDHLILNVEWAKP 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3g2	NP_650887.1	eIF3g	28..137	CDD:289149	60/113 (53%)
		RRM	<171..>256	CDD:223796	36/84 (43%)
		RRM_eIF3G_like	194..270	CDD:240854	40/75 (53%)
eif3g	NP_957293.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		8/19 (42%)
		eIF3G	35..147	CDD:240597	58/111 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..206		13/43 (30%)
		RRM	<172..>293	CDD:223796	58/120 (48%)
		RRM_eIF3G_like	213..289	CDD:240854	40/75 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589064
Domainoid	1	1.000	130	1.000	Domainoid score	I5169
eggNOG	1	0.900	-	-		E1_KOG0122
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2784
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3194
OMA	1	1.010	-	-		QHG55427
OrthoDB	1	1.010	-	-		D1226059at2759
OrthoFinder	1	1.000	-	-		FOG0003558
OrthoInspector	1	1.000	-	-		otm25678
orthoMCL	1	0.900	-	-		OOG6_102687
Panther	1	1.100	-	-	O	PTHR10352
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R382
SonicParanoid	1	1.000	-	-		X2433
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	16	15.840