Protein Alignment Tmlh and AIM17

DIOPT Version :10

• Sequence 1: NP_650886.1
• Gene: Tmlh / 42421
• FlyBaseID: FBgn0038795
• Length: 364
• Species: Drosophila melanogaster
• Sequence 2: NP_011842.1
• Gene: AIM17 / 856365
• SGDID: S000001013
• Length: 465
• Species: Saccharomyces cerevisiae
• Alignment Length: 411
• Identity: 99/411 - (24%)
• Similarity: 165/411 - (40%)
• Gaps: 76/411 - (18%)

  Fly    12 SIEINEFWLRDHCRCVECLNFETNQRRY--DVLDLPADIMPLDVKYDGMNLQVQWSDAHKSNYDL 74
            |:..|..:|||.....:.:   |....|  :.|..|.||   .:..||.:|.|:|.|.....:.|
Yeast    61 SVCFNNVFLRDASHSAKLV---TTGELYHNEKLTAPQDI---QISEDGKSLVVKWKDGGHHQFPL 119

  Fly    75 DFIFDSQLERLI--GRRSKSTNLTP--WNRSIILQNERHL------RFPLPQLVSSDNEVRSLVE 129
            .|..|.:....:  ..|.:.:...|  ||:.|:..|.:.|      .|..|:   .|:::...:.
Yeast   120 QFFIDYKGSSFVSPATRKQESRYRPQLWNKRILKDNVKDLLSVSYNEFIDPK---DDSKLFQTLV 181

  Fly   130 SLVRYGIVFIDDVAPTANMTELALR----RVFPLMKTFFGEMWTFSDNPDHADTA---YTKLYLG 187
            :|.::||.||.. .|:::...|.::    |:.|:..|..|| .||..|...|.:.   |....|.
Yeast   182 NLQKFGIAFISG-TPSSSSEGLTIQKICERIGPIRSTVHGE-GTFDVNASQATSVNAHYANKDLP 244

  Fly   188 SHTDNTYFCDAAGLQALHCI-----EHSGSGGENFFVDGLHVVHELKRRYPAAYDVLCSVQVPGE 247
            .|||..:..:..|.|.|..:     |...:...|:|||..:....::.....||:.|  ..||..
Yeast   245 LHTDLPFLENVPGFQILQSLPATEGEDPNTRPMNYFVDAFYATRNVRESDFEAYEAL--QIVPVN 307

  Fly   248 YI-EKGE-HHYHTAPIIQVDPLTQEFVQL--------------------RLNVYDR-AVFN---- 285
            || |.|: .:|.:.|:|:...:.::...|                    ...:||: :..|
Yeast   308 YIYENGDKRYYQSKPLIEHHDINEDNTLLGNYEALIKCINYSPPYQAPFTFGIYDKPSDLNNNLD 372

  Fly   286 ----TIPQAEMAE---FYDSLRQLLLI---VRDKQQQWALKLCPGSIVLFDNWRVLHGREAYTGS 340
                |.| |::.|   |...:|.|.|.   :.|...|:.|:|.....|:|:|.|:||.....:.:
Yeast   373 LNLITTP-AKLTERFLFKSFIRGLNLFESHINDFNNQFRLQLPENCCVIFNNRRILHANSLTSSN 436

  Fly   341 RT-MSGSYVQRTDFLSKARVL 360
            :. :.|.|.....|.||.:.|
Yeast   437 QQWLKGCYFDSDTFKSKLKFL 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmlh	NP_650886.1	CAS_like	19..361	CDD:444731	97/404 (24%)
AIM17	NP_011842.1	CAS_like	128..448	CDD:238154	75/327 (23%)