DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4335 and tmlhe

DIOPT Version :9

Sequence 1:	NP_650886.1	Gene:	CG4335 / 42421	FlyBaseID:	FBgn0038795	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	XP_682831.3	Gene:	tmlhe / 555271	ZFINID:	ZDB-GENE-091204-144	Length:	410	Species:	Danio rerio

Alignment Length:	355	Identity:	125/355 - (35%)
Similarity:	187/355 - (52%)	Gaps:	21/355 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 WLRDHCRCVECLNFETNQRRYDVLDLPADIMPLDVKYDGMNLQVQWSDAHKSNYDLDFI----FD 79
            |||||||...|.|.:||||..|...:...|.|...:.|..||.:.|.|.|.:.|:|.::    ::
Zfish    64 WLRDHCRSASCYNSKTNQRNLDTASIDLTIRPSKSRVDEHNLFLTWPDGHVTRYNLAWLAQNSYE 128

  Fly    80 SQLERLIGRRSKSTNLTPWNRSIILQNERHLRFPL---PQLVSSDNEVRSLVESLVRYGIVFIDD 141
            .|:...|..|      ..||..|.    ...:.|.   .:.:|.|.|:::.:.:.:.|||.|::.
Zfish   129 GQMRSAIQPR------ILWNAHIY----SSAKVPAANWDKFMSCDEELKNFLNNFLLYGIAFVEG 183

  Fly   142 VAPTANMTELALRRVFPLMKTFFGEMWTFSDNPDHADTAYTKLYLGSHTDNTYFCDAAGLQALHC 206
            |.||...||...:||..:.:|.:|.||.|:.:....|||||||.|..|||.:||.:..|:|..||
Zfish   184 VPPTLEATETVTQRVSLIRETIYGRMWNFTSDFSRGDTAYTKLALDRHTDTSYFQEPCGIQVFHC 248

  Fly   207 IEHSGSGGENFFVDGLHVVHELKRRYPAAYDVLCSVQVPGEYIEK-GEHHYH---TAPIIQVDPL 267
            :.|.|:||....|||.|....:.::.|..:.:|..|.:..:|:|. .:|..|   ..|::.|.|.
Zfish   249 LRHEGTGGRTLLVDGFHAADTVLQQTPENFQLLSHVPIKHDYVENLSDHRNHMIGIGPVLNVYPW 313

  Fly   268 TQEFVQLRLNVYDRAVFNTIPQAEMAEFYDSLRQLLLIVRDKQQQWALKLCPGSIVLFDNWRVLH 332
            ..|...:|.|.|||:|.||:|...:..:|.:.|:|...:|....:..:||.||.::..|||||||
Zfish   314 NNEVYMIRYNNYDRSVINTVPHDVVRRWYVAHRKLTAELRRADNELWVKLKPGKVLFVDNWRVLH 378

  Fly   333 GREAYTGSRTMSGSYVQRTDFLSKARVLGI 362
            |||::||.|.:.|.|:.|.|.|:.||.||:
Zfish   379 GRESFTGLRQLCGCYLTRDDVLNTARSLGL 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4335	NP_650886.1	carnitine_TMLD	19..361	CDD:274119	123/352 (35%)
		DUF971	<19..70	CDD:294847	22/50 (44%)
		CAS_like	110..350	CDD:294121	88/246 (36%)
tmlhe	XP_682831.3	DUF971	49..122	CDD:294847	24/57 (42%)
		carnitine_TMLD	60..408	CDD:274119	124/353 (35%)
		CAS_like	132..397	CDD:238154	93/274 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587914
Domainoid	1	1.000	185	1.000	Domainoid score	I3328
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H21853
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3323
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D534559at33208
OrthoFinder	1	1.000	-	-		FOG0005559
OrthoInspector	1	1.000	-	-		oto40917
orthoMCL	1	0.900	-	-		OOG6_104988
Panther	1	1.100	-	-	LDO	PTHR10696
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2023
SonicParanoid	1	1.000	-	-		X4529
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.930