Protein Alignment Tmlh and TMLHE

DIOPT Version :10

• Sequence 1: NP_650886.1
• Gene: Tmlh / 42421
• FlyBaseID: FBgn0038795
• Length: 364
• Species: Drosophila melanogaster
• Sequence 2: NP_060666.1
• Gene: TMLHE / 55217
• HGNCID: 18308
• Length: 421
• Species: Homo sapiens
• Alignment Length: 371
• Identity: 129/371 - (34%)
• Similarity: 203/371 - (54%)
• Gaps: 25/371 - (6%)

  Fly     4 LKHPKTSQSIEINEFWLRDHCRCVECLNFETNQRRYDVLDLPADIMPLDVKYDGMNLQVQWSDAH 68
            ||:..|  .:..:..|||||||...|.|.:|:||..|...:...|.|..::.|...|...|.|.|
Human    62 LKYANT--VMRFDYVWLRDHCRSASCYNSKTHQRSLDTASVDLCIKPKTIRLDETTLFFTWPDGH 124

  Fly    69 KSNYDLDFIFDSQLERLIGRRSKSTNLTP---WNRSIILQNERHLRFPLPQL-----VSSDNEVR 125
            .:.|||:::..:..|   |::.|.  :.|   ||..|..|.:      :|.:     :.::..::
Human   125 VTKYDLNWLVKNSYE---GQKQKV--IQPRILWNAEIYQQAQ------VPSVDCQSFLETNEGLK 178

  Fly   126 SLVESLVRYGIVFIDDVAPTANMTELALRRVFPLMKTFFGEMWTFSDNPDHADTAYTKLYLGSHT 190
            ..:::.:.|||.|:::|.||...||....|:..:.:|.:|.||.|:.:....|||||||.|..||
Human   179 KFLQNFLLYGIAFVENVPPTQEHTEKLAERISLIRETIYGRMWYFTSDFSRGDTAYTKLALDRHT 243

  Fly   191 DNTYFCDAAGLQALHCIEHSGSGGENFFVDGLHVVHELKRRYPAAYDVLCSVQVPGEYIEK-GEH 254
            |.|||.:..|:|..||::|.|:||....|||.:...::.::.|..:::|..|.:..||||. ||.
Human   244 DTTYFQEPCGIQVFHCLKHEGTGGRTLLVDGFYAAEQVLQKAPEEFELLSKVPLKHEYIEDVGEC 308

  Fly   255 HYH---TAPIIQVDPLTQEFVQLRLNVYDRAVFNTIPQAEMAEFYDSLRQLLLIVRDKQQQWALK 316
            |.|   ..|::.:.|..:|...:|.|.|||||.||:|...:..:|.:.|.|.:.:|..:.::.:|
Human   309 HNHMIGIGPVLNIYPWNKELYLIRYNNYDRAVINTVPYDVVHRWYTAHRTLTIELRRPENEFWVK 373

  Fly   317 LCPGSIVLFDNWRVLHGREAYTGSRTMSGSYVQRTDFLSKARVLGI 362
            |.||.::..||||||||||.:||.|.:.|.|:.|.|.|:.||:||:
Human   374 LKPGRVLFIDNWRVLHGRECFTGYRQLCGCYLTRDDVLNTARLLGL 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmlh	NP_650886.1	CAS_like	19..361	CDD:444731	124/353 (35%)
TMLHE	NP_060666.1	carnitine_TMLD	70..419	CDD:274119	125/359 (35%)