DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir92a and grin2da

DIOPT Version :9

Sequence 1:	NP_001097845.2	Gene:	Ir92a / 42415	FlyBaseID:	FBgn0038789	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_009292354.1	Gene:	grin2da / 449864	ZFINID:	ZDB-GENE-041008-124	Length:	1916	Species:	Danio rerio

Alignment Length:	780	Identity:	155/780 - (19%)
Similarity:	267/780 - (34%)	Gaps:	217/780 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VYNNSASTTPLQLEYLSALELVLRELSKPIRLQWINVAFLKDLNDLEDQVMGALNSSVTEGFI-- 93
            ||...:.:|.||||.:..   ||.|      ..|...:.:...:...:..:..:...:...||
Zfish   191 VYLQFSCSTDLQLEVIFE---VLEE------FDWTAFSVVTTRHHGYEDFLAMVEGMIDGSFIGW 246

  Fly    94 -----TILSQTHHFIHARYYATR------NANVRLKDKRYLFLCEDESPAELL--CMDILQFYPH 145
                 .:|:.|.....||   ||      .|.||      |..|..|...::.  .....|..|.
Zfish   247 ERKSVVMLNLTDDPGGAR---TRRLLKENEAQVR------LLYCSQEEAEQIFKAAWASGQATPS 302

  Fly   146 HL--MVRP-----GTETAPTG-----PTGPHPDPRR--GGGASVST------KNKDDGEGGA--- 187
            |:  .|.|     |.|..|..     |.|...:|||  ..|.||.|      :.:..|..|.
Zfish   303 HMWFAVGPGLSGLGLEGLPKALFAVRPQGWRDEPRRRIAKGVSVLTHGAMALRREYGGARGTSFA 367

  Fly   188 ------GNKT-------------TSPYRDINFELWTQKFVGAVGNLDALLLDAFLPNETFA---- 229
                  ||:|             |...||.:|            |.|..|.:..|...::.
Zfish   368 GNCMMDGNQTQRVPGRIRFFSNITLSGRDYSF------------NNDGYLANPLLDVISYTAGRG 420

  Fly   230 -NRVELYPNKLLNLQ----------------RRSLLVGSITYVPYTITNYVPAGQGDV--DPIHP 275
             ..|..:.|.:|.|:                .:.|.|.::...|:.|......|.|..  |.:..
Zfish   421 WEEVGWWENGVLRLRYPPWSRYGPFLKPLDDSQHLRVVTLEERPFVIVEPADPGTGSCIRDSVPC 485

  Fly   276 QWP-NRSLTFDGAEA----------NVMKTFCQV----HNCHLRVEAYGADNWGGIYDNESSDGM 325
            :.| |.|:..:|.::          :|:|...::    ::.:|........|..|.:     :||
Zfish   486 RLPLNNSMVVEGIQSMKHCCKGFCIDVLKRLAKIVGFTYDLYLVTNGRHGKNIDGQW-----NGM 545

  Fly   326 LGDIYEQRVEMAIGCIYNWYDGITETSHTIARSSVTILGPAPAPLPSWRTN--------IMPFNN 382
            :|::..:|.:||||.:     .|.|....:...||..:....:.:.| |:|        :.|::.
Zfish   546 VGEVVSKRADMAIGSL-----TINEERSEVVEFSVPFVETGISVMVS-RSNGTVSPSAFLEPYSP 604

  Fly   383 RAWL---VLISTLVICGTFLY-FMKYVSY-RLRYSGTQV---KFHHSRKLEKSMLDIFALF---- 435
            ..|:   |:..::|....|:: |...|.| |...||...   ||    .:.||:..::||.
Zfish   605 AVWVMMFVMCLSVVAVTVFIFEFFSPVGYNRSLQSGKTAGGSKF----TIGKSIWLLWALVFNNS 665

  Fly   436 --IQQPSAPLSFDRFAPRFFLATILCATITLENIYSGQLKSMLTFPFYSAPVDTIEKWAQSGWKW 498
              ::.|....|........|.|.|..|:.|         .::..|......:||:.  ..|..|:
Zfish   666 VPVENPRGTTSKIMVLVWAFFAVIFLASYT---------ANLAAFMIQEEYIDTVS--GLSDKKF 719

  Fly   499 SAPSIIWVHTVQSSDL--------ETEQILARNF-EVHDYSYLSNVSFMPNYGFGIERLSSGSLS 554
            ..|      |.|...|        .||:.:..|: .:|.|...:|...:.:   .||.|.:|.|.
Zfish   720 QHP------TEQYPPLRFGTVPNGSTEENIRSNYPNMHQYMVRNNQRGVED---AIENLKTGKLD 775

  Fly   555 VGDYVSTEALENRIVLHDDLYFDYTRAVSIRGWILMPELNKHIRTCQETGLYFH----WE----- 610
            .  ::...|:.|.:...|:            |..:|...:..:......|:..|    |:
Zfish   776 A--FIYDAAVLNYMARKDE------------GCKVMTIGSGKVFATTGYGVALHKNSRWKRPLDL 826

  Fly   611 --LEFI-DKYMDKKKQEVLMDLANGHKVKGAPQALDVRNIAGALFVLAFGVAFAGCALVAELLIH 672
              |:.: |..:|..::..|..:.:..|::.....||:.|:||..::|...:..:......|.|::
Zfish   827 ALLQLVGDDEIDMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVY 891

Fly 673 672
Zfish 892 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir92a	NP_001097845.2	None
grin2da	XP_009292354.1	PBP1_iGluR_NMDA_NR2	42..441	CDD:107373	59/279 (21%)
		PBP2_iGluR_NMDA_Nr2	452..851	CDD:270436	87/447 (19%)
		HisJ	<507..>590	CDD:223904	19/93 (20%)
		Lig_chan	605..877	CDD:278489	62/309 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591663
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930