DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir92a and GluRIIE

DIOPT Version :9

Sequence 1:	NP_001097845.2	Gene:	Ir92a / 42415	FlyBaseID:	FBgn0038789	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster

Alignment Length:	821	Identity:	156/821 - (19%)
Similarity:	256/821 - (31%)	Gaps:	285/821 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LQPLVMHLSQLLRIIVGQYFAEFPSILIVYNNSASTTPLQLEYLSALELVLRELSKPIRLQWINV 67
            |.|....|::.|..::.::  .:...:.:|.::        |||:    :|.||:..:......:
  Fly   138 LHPHPADLAKALYSLITEF--NWTRFIFLYESA--------EYLN----ILNELTTMLGKSGTVI 188

  Fly    68 AFLK---DLNDLEDQVMGALNSSVTEGFITI---------LSQTHH--FIHARY-YATRNANVR- 116
            ..|:   .||....||:..:..||....:.:         |:|...  .|:..| |...|.:..
  Fly   189 TVLRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHS 253

  Fly   117 --LKDKRY---------LFLCEDESPAELL----------------CMDILQFYPHHLMVRPGTE 154
              |::.:|         ||..|..:..|||                |...::....:..|:...:
  Fly   254 FDLEEYKYSEANITGLRLFSPEKMAVKELLMKLGYPTDQDEFRNGSCPITVEMALTYDAVQLFAQ 318

  Fly   155 TAPTGPTGPHPDPRRGGGASVSTKN-KDDGEGGAGNKTTSPYRD------INFE----------- 201
            |....|..|.|.     ..|..|:: :|||........|....|      |.||
  Fly   319 TLKNLPFKPMPQ-----NCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEGNVRKGYHLDV 378

  Fly   202 ------------LW-------TQKFVGAVGNLDALLLDAFLPNETFANRVELYPNKLLNLQRRSL 247
                        .|       .|:........|:  :|..|.|:||...:.: |||
  Fly   379 IELQPSGIVKVGTWDEDRQYRPQRLAPTTAQFDS--VDNSLANKTFIILLSV-PNK--------- 431

  Fly   248 LVGSITYVPYTITNYVPAGQGDVDPIHPQWPNRSLTFDGAEANVMKTFCQVHNCHLRVEAYGAD- 311
                    ||                               |.:::|:.|:.. :.:.|.||.|
  Fly   432 --------PY-------------------------------AQLVETYKQLEG-NSQYEGYGVDL 456

  Fly   312 ---------------NWGGIY------DNESSDGMLGDIYEQRVEMAIGCIYNWYDGITETSHTI 355
                           |.|..|      .|||: |||.:|...|.::||       ..:|.||...
  Fly   457 IKELADKLGFNFTFVNGGNDYGSYNKSTNEST-GMLREIMTGRADLAI-------TDLTITSERE 513

  Fly   356 ARSSVTI-----------LGPAPAPLPSWRTNIMPFNNRAWLVLISTLVICGTFLYFMKYVSYRL 409
            .....||           |.|..| .|...|.:.||:...|..|..:.:  |..|.|  ::..||
  Fly   514 QALDFTIPFMNLGIAILYLKPQKA-TPELFTFMDPFSEEVWWFLGFSFL--GVSLSF--FILGRL 573

  Fly   410 ---RYSGTQVKFHHSRKLEKSMLDIFAL----------FIQQPSAPLSFDRFAPRFFLATILCA- 460
               .:...........:||..    |.|          .:||.|      ...|: .|:|...|
  Fly   574 SPSEWDNPYPCIEEPEELENQ----FTLGNSIWFTTGALLQQGS------EIGPK-ALSTRTVAS 627

  Fly   461 -----TITLENIYSGQLKSMLTFPFYSAPVDTIEKWA--QSGWKWSAPSIIWVHTVQSSDLETEQ 518
                 |:.:.:.|:..|.:.||.....:.:::::..|  :.|..:.|...........:..|...
  Fly   628 FWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFFMTSAEERY 692

  Fly   519 ILARNFEVHDYSYL--------SNVSFMPNYGFGIERLS--------SGSLSVGDYVSTEALENR 567
            .....|...:..||        :.|....:|.|.:|..|        .....:||     ||:.:
  Fly   693 KKMNKFMSENPQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRECNLKKIGD-----ALDEK 752

  Fly   568 ---IVLHDDLYFDYTRAVSIRGWILMPELNKHIRTCQETGLYFHWELEFIDKYMDKKKQEVLMDL 629
               |.:..|             |....:.|..:...||.|:            ::|.|.:...::
  Fly   753 GYGIAMRKD-------------WPHRGKFNNALLELQEQGV------------LEKMKNKWWNEV 792

  Fly   630 ANG--HKVKGAPQA--LDVRNIAGALFVLAFGVAFAGCALV 666
            ..|  ...:.||.|  ||:.|:.|..|||..|   :.|||:
  Fly   793 GTGICATKEDAPDATPLDMNNLEGVFFVLLVG---SCCALL 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir92a	NP_001097845.2	None
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	49/276 (18%)
		ANF_receptor	51..382	CDD:279440	48/262 (18%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	88/474 (19%)
		Lig_chan	551..824	CDD:278489	59/317 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462853
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840