DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir92a and Grik3

DIOPT Version :9

Sequence 1:	NP_001097845.2	Gene:	Ir92a / 42415	FlyBaseID:	FBgn0038789	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001106187.1	Gene:	Grik3 / 298521	RGDID:	71027	Length:	919	Species:	Rattus norvegicus

Alignment Length:	795	Identity:	155/795 - (19%)
Similarity:	271/795 - (34%)	Gaps:	236/795 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LQPLVMHLSQLLRIIVGQYFAEFPSILIVYNNSASTTPLQLEYLSA-----LELVLREL------ 56
            |...::.|.|.|:         :.|..:||::|.....|| |.:.|     :.|.:|:|
  Rat   159 LSHAILDLVQSLK---------WRSATVVYDDSTGLIRLQ-ELIMAPSRYNIRLKIRQLPIDSDD 213

  Fly    57 SKPIRLQWINVAFLKDLNDLED--------QVMGA--LNSSVTEGFITILSQTHHFIHAR--YYA 109
            |:|:         ||::....:        ..|.|  |..::..|.:|   :.:|||...  .||
  Rat   214 SRPL---------LKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMT---EYYHFIFTTLDLYA 266

  Fly   110 T-----RNANVRLKDKRYLFLCEDESP-----AELLCMDILQFYPH------------------- 145
            .     |.:.|.|...|.|.:   ::|     .|...|:.||..|.
  Rat   267 LDLEPYRYSGVNLTGFRILNV---DNPHVSAIVEKWSMERLQAAPRAESGLLDGVMMTDAALLYD 328

  Fly   146 --HLMVRPGTETAPTGPTGPHPDPR----RGGGASVSTKNKDDGEGGAG----NKTTSPYRDINF 200
              |: |....:.||..........|    |.||..::...:...||..|    |||:....|.:.
  Rat   329 AVHI-VSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDL 392

  Fly   201 ELWTQK-----FVGAVGNLDALLLDAFLPNETFANRVELYPNKLLNLQRRSLLVGSITYVPYTIT 260
            ::.:.|     .||.....|.|.:     .|....|   .||...:|..|||:|.::...|:.:.
  Rat   393 DIISLKEDGLEKVGVWSPADGLNI-----TEVAKGR---GPNVTDSLTNRSLIVTTLLEEPFVMF 449

  Fly   261 NYVPAGQGDVDPIHPQWPNRSL----TFDGAEANVMKTFCQVHNCHLRVEAYGADNWGGIYDNES 321
                           :..:|:|    .|:|...:::|....:......:.......:|...|...
  Rat   450 ---------------RKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQ 499

  Fly   322 SDGMLGDIYEQRVEMAIG--CIYNWYDGITETSHTIARSSVTILGPAP-APLPSWRTNIMPFNNR 383
            .:||:.::.:.:.::|:.  .|.:..:...:.|.......|:||...| ...||..:.:.|.:..
  Rat   500 WNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPD 564

  Fly   384 AWL-VLISTL-VICGTFLY--FMKYVSYRLR--YSGTQVKFHHSRKLEKSMLDIFALFIQQPSAP 442
            .|: ||::.| |.|..|:.  |..|..|...  ..|::|..::...|......:.:| :||.|
  Rat   565 IWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSL-MQQGS-- 626

  Fly   443 LSFDRFAPR------------FFLATI-------LCATITLENIYS----------------GQL 472
                ...|:            ||...|       |.|.:|:|.:.|                |.:
  Rat   627 ----ELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAV 687

  Fly   473 KSMLTFPFY-SAPVDTIEK-WAQSGWKWSAPSIIWVHTVQSSDLETEQILARNFEVHDYSYL--- 532
            |...|..|: .:.:.|.|| ||   :..|.||.:    |::::...::.|..     ||:.|
  Rat   688 KDGATMTFFKKSKISTFEKMWA---FMSSKPSAL----VKNNEEGIQRTLTA-----DYALLMES 740

  Fly   533 SNVSFMPNYGFGIERLSSGSLSVGDYVSTEALENRIVLHDDLYFDYTRAVSIRGWILMPELNKHI 597
            :.:.::......:.::.....|.|..:.|           .:...|...::|....|..|...||
  Rat   741 TTIEYITQRNCNLTQIGGLIDSKGYGIGT-----------PMGSPYRDKITIAILQLQEEDKLHI 794

  Fly   598 RTCQETGLYFHWELEFIDKYMDKKKQEVLMDLANGHKVKGAPQ-------ALDVRNIAGALFVLA 655
            .                     |:|         ..:..|.|:       ||.::.|.|...|||
  Rat   795 M---------------------KEK---------WWRGSGCPEEENKEASALGIQKIGGIFIVLA 829

  Fly   656 FGVAFAGCALVAELL 670
            .|:..:....|.|.:
  Rat   830 AGLVLSVLVAVGEFI 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir92a	NP_001097845.2	None
Grik3	NP_001106187.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	60/288 (21%)
		ANF_receptor	55..398	CDD:279440	55/264 (21%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	78/442 (18%)
		Lig_chan	564..832	CDD:278489	63/327 (19%)
		Glutamate binding	690..692		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350123
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840