Protein Alignment Ir92a and Grik1

DIOPT Version :10

• Sequence 1: NP_001097845.2
• Gene: Ir92a / 42415
• FlyBaseID: FBgn0038789
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_001104587.1
• Gene: Grik1 / 29559
• RGDID: 2732
• Length: 949
• Species: Rattus norvegicus
• Alignment Length: 844
• Identity: 165/844 - (19%)
• Similarity: 275/844 - (32%)
• Gaps: 311/844 - (36%)

  Fly     3 LQPLVMHLSQLLRIIVGQYFAEFPSILIVYNNSASTTPLQLEYLSA-----LELVLREL------ 56
            |.|....:|:.:..:|..|  .:.::.:||.:|.....|| |.:.|     :::.:|:|
  Rat   150 LYPDYAAISRAVLDLVLYY--NWKTVTVVYEDSTGLIRLQ-ELIKAPSRYNIKIKIRQLPPANKD 211

  Fly    57 SKPIRLQWINVAFLKDLN---------DLEDQVMGALNSSVTEGFITILSQTHHFIHARYYAT-- 110
            :||:         ||::.         |...:....:...:.  |:.::::.:|:    ::.|
  Rat   212 AKPL---------LKEMKKSKEFYVIFDCSHETAAEILKQIL--FMGMMTEYYHY----FFTTLD 261

  Fly   111 ---------RNANVRLKDKRYLFLCEDESP-----AELLCMDILQFYPHHLMVRPGTETAPTGPT 161
                     |.:.|.:...|.|.:   ::|     .|...|:.||..|     ||.|.......|
  Rat   262 LFALDLELYRYSGVNMTGFRLLNI---DNPHVSSIIEKWSMERLQAPP-----RPETGLLDGMMT 318

  Fly   162 --------------------------------------GPH-----PDPRRGGGASVSTKNKDDG 183
                                                  ||.     .:.|..|.....|.||.||
  Rat   319 TEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGRITFNKTDG 383

  Fly   184 -------------EGGAGNKTTSPYRDINFELWTQKFVGAVGNLDALLLDAFLPNETFANRVELY 235
                         |.|. .|.:.......:::|  |.:|...:...|       |.|..|| :..
  Rat   384 LRKDFDLDIISLKEEGT-EKASGEVSKHLYKVW--KKIGIWNSNSGL-------NMTDGNR-DRS 437

  Fly   236 PNKLLNLQRRSLLVGSITYVPYTITNYVPAGQGDVDPIHPQWPNRSLTFDGAEANVMKTFCQVHN 300
            .|...:|..|:|:|.:|...||.:..     :.|    .|.:.|.  .|:|...:::|....:..
  Rat   438 NNITDSLANRTLIVTTILEEPYVMYR-----KSD----KPLYGND--RFEGYCLDLLKELSNILG 491

  Fly   301 CHLRVE-----AYGADNWGGIYDNESSDGMLGDIYEQRVEMAIGCIYNWY--DGITETSHTIARS 358
            ....|:     .|||.|     |....:||:.::.:.|.::|:..:...|  :.:.:.|......
  Rat   492 FLYDVKLVPDGKYGAQN-----DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTL 551

  Fly   359 SVTILGPAP-APLPSWRTNIMPFNNRAWL-VLISTL-VICGTFLY--FMKYVSYRLR--YSGTQV 416
            .::||...| ...|...:.:.|.:...|: ||::.| |.|..|:.  |..|..|...  ...:.|
  Rat   552 GISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDV 616

  Fly   417 KFHHSRKLEKSMLDIFALFIQQPSAPLSFDRFAPR------------FFLATI-------LCATI 462
            ..::...|......:.|| :||.|      ...|:            ||...|       |.|.:
  Rat   617 VENNFTLLNSFWFGVGAL-MQQGS------ELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFL 674

  Fly   463 TLENIYS----------------GQLK--SMLTFPFYSAPVDTIEK-WA-QSGWKWSAPSIIWVH 507
            |:|.:.|                |.::  |.:|| |..:.:.|.|| || .|..:.||
  Rat   675 TVERMESPIDSADDLAKQTKIEYGAVRDGSTMTF-FKKSKISTYEKMWAFMSSRQQSA------- 731

  Fly   508 TVQSSDLETEQILARNFEVHDYSYLSNVSFMPNYGFGIERLSSGSLSVGDYVSTEALENRIVLHD 572
            .|::||...:::|..     ||:.|               :.|.|:   :||:.
  Rat   732 LVKNSDEGIQRVLTT-----DYALL---------------MESTSI---EYVTQ----------- 762

  Fly   573 DLYFDYTRAVSIRGWILMPELNKHIRTCQET---GLYFHWELEFIDK------------YMDKKK 622
                                     |.|..|   ||        ||.            |.||..
  Rat   763 -------------------------RNCNLTQIGGL--------IDSKGYGVGTPIGSPYRDKIT 794

  Fly   623 QEVLMDLANG--HKVK-------GAPQ-------ALDVRNIAGALFVLAFGVAFAGCALVAELL 670
            ..:|.....|  |.:|       |.|:       ||.|.||.|...|||.|:..:....:.|.|
  Rat   795 IAILQLQEEGKLHMMKEKWWRGNGCPEEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFL 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir92a	NP_001097845.2	None
Grik1	NP_001104587.1	PBP1_iGluR_Kainate	38..431	CDD:380605	53/316 (17%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	93/466 (20%)