DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir92a and GRIN2D

DIOPT Version :10

Sequence 1:NP_001097845.2 Gene:Ir92a / 42415 FlyBaseID:FBgn0038789 Length:678 Species:Drosophila melanogaster
Sequence 2:NP_000827.2 Gene:GRIN2D / 2906 HGNCID:4588 Length:1336 Species:Homo sapiens


Alignment Length:449 Identity:89/449 - (19%)
Similarity:166/449 - (36%) Gaps:105/449 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   288 EANVMKTFC------QVHNCHLRVEAYGADNW------GGIYDNESSDGMLGDIYEQRVEMAIGC 340
            |....|.||      ..|......:.|...|.      .|::     :||:|:::.||.:||||.
Human   480 EKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVW-----NGMIGEVFYQRADMAIGS 539

  Fly   341 ---------IYNWYDGITET--SHTIARSSVTILGPAPAPLPSWRTNIMPFNNRAWL---VLIST 391
                     |.::.....||  |..:|||:.|:   :|:..      :.|::...|:   |:..|
Human   540 LTINEERSEIVDFSVPFVETGISVMVARSNGTV---SPSAF------LEPYSPAVWVMMFVMCLT 595

  Fly   392 LVICGTFLY-FMKYVSYRLRYSGTQVKFHHSRKLEKSMLDIFALF------IQQPSAPLSFDRFA 449
            :|....|:: ::..|.|....:..:.....:..:.||:..::||.      ::.|....|.....
Human   596 VVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVL 660

  Fly   450 PRFFLATILCATITLENIYSGQLKSMLTFPFYSAPVDTIEKWAQSGWKWSAPS----IIWVHTVQ 510
            ...|.|.|..|:.|         .::..|......|||:.  ..|..|:..|.    .:...||.
Human   661 VWAFFAVIFLASYT---------ANLAAFMIQEEYVDTVS--GLSDRKFQRPQEQYPPLKFGTVP 714

  Fly   511 SSDLETEQILARNF-EVHDYSYLSNVSFMPNYGFGIERLSSGSLSVGDYVSTEALENRIVLHDDL 574
            :.  .||:.:..|: ::|.|....|   .|.....:.:|.:|.|..  ::...|:.|.:...|: 
Human   715 NG--STEKNIRSNYPDMHSYMVRYN---QPRVEEALTQLKAGKLDA--FIYDAAVLNYMARKDE- 771

  Fly   575 YFDYTRAVSIRGWILMPELNKHIRTCQETGLYFH----WE-------LEFI-DKYMDKKKQEVLM 627
                       |..|:...:..:......|:..|    |:       |:|: |..::..::..|.
Human   772 -----------GCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLS 825

  Fly   628 DLANGHKVKGAPQALDVRNIAGALFVLAFGVAFAGCALVAELLI-----------HRMD 675
            .:.:..|::.....||:.|:||..::|...:..:......|.|:           ||||
Human   826 GICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMD 884

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir92aNP_001097845.2 None
GRIN2DNP_000827.2 PBP1_iGluR_NMDA_NR2 49..413 CDD:380601
PBP2_iGluR_NMDA_Nr2 430..830 CDD:270436 76/393 (19%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:Q00960 631..650 4/18 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 900..934
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 981..1123
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1225..1336
PDZ-binding. /evidence=ECO:0000250 1334..1336
Blue background indicates that the domain is not in the aligned region.

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