DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir92a and GRIN2B

DIOPT Version :10

Sequence 1:NP_001097845.2 Gene:Ir92a / 42415 FlyBaseID:FBgn0038789 Length:678 Species:Drosophila melanogaster
Sequence 2:NP_000825.2 Gene:GRIN2B / 2904 HGNCID:4586 Length:1484 Species:Homo sapiens


Alignment Length:385 Identity:74/385 - (19%)
Similarity:149/385 - (38%) Gaps:63/385 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   319 NESSDGMLGDIYEQRVEMAIGCIYNWYDGITETSHTIARSSVTILGPAPAPLPSWRTN------- 376
            |.:.:||:|::..:|..||:|.:     .|.|....:...||..:....:.:.| |:|       
Human   491 NGTWNGMIGEVVMKRAYMAVGSL-----TINEERSEVVDFSVPFIETGISVMVS-RSNGTVSPSA 549

  Fly   377 -IMPFNNRAWLVL-ISTLVICGTFLYFMKY---VSYRLRYSGTQVKFHHSRKLEKSMLDIFALF- 435
             :.||:...|::: :..|::....::..:|   |.|....:..:.....|..:.|::..::.|. 
Human   550 FLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVF 614

  Fly   436 -----IQQPSAPLSFDRFAPRFFLATILCATITLENIYSGQLKSMLTFPFYSAPVDTI----EKW 491
                 :|.|....|....:...|.|.|..|:.|         .::..|......||.:    :|.
Human   615 NNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYT---------ANLAAFMIQEEYVDQVSGLSDKK 670

  Fly   492 AQSGWKWSAPSIIWVHTVQSSDLETEQILARNF-EVHDYSYLSNVSFMPNYGFGIE----RLSSG 551
            .|....:|.|  ....||.:.  .||:.:..|: |:|.|....|..       |::    .|.:|
Human   671 FQRPNDFSPP--FRFGTVPNG--STERNIRNNYAEMHAYMGKFNQR-------GVDDALLSLKTG 724

  Fly   552 SLSVGDYVSTEALENRIVLHDDLYFDYTRAVSIRGWILMPELNKHIRTCQETGLYFHWELEFIDK 616
            .|..  ::...|:.|.:...|    :..:.|:|....:.......|...:::|.....:|..:..
Human   725 KLDA--FIYDAAVLNYMAGRD----EGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQL 783

  Fly   617 YMDKKKQEV----LMDLANGHKVKGAPQALDVRNIAGALFVLAFGVAFAGCALVAELLIH 672
            :.|.:.:|:    |..:.:..|.:.....||:.|:||..::|...:|.:....:.|.|.:
Human   784 FGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLFY 843

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir92aNP_001097845.2 None
GRIN2BNP_000825.2 PBP1_iGluR_NMDA_NR2 33..388 CDD:380601
PBP2_iGluR_NMDA_Nr2 403..803 CDD:270436 64/343 (19%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:A7XY94 604..623 3/18 (17%)
NMDAR2_C 840..1484 CDD:463148 1/4 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1074..1097
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1161..1194
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1271..1301
Interaction with DAPK1. /evidence=ECO:0000250|UniProtKB:Q01097 1292..1304
PDZ-binding. /evidence=ECO:0000250 1482..1484
Blue background indicates that the domain is not in the aligned region.

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