DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir92a and GRIK4

DIOPT Version :9

Sequence 1:	NP_001097845.2	Gene:	Ir92a / 42415	FlyBaseID:	FBgn0038789	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001269399.1	Gene:	GRIK4 / 2900	HGNCID:	4582	Length:	956	Species:	Homo sapiens

Alignment Length:	743	Identity:	132/743 - (17%)
Similarity:	250/743 - (33%)	Gaps:	227/743 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SILIVYNNSASTTPLQLEYLSALELVLRELSKPIRLQWINVAF-LKDLNDLEDQVMGALNSSVTE 90
            :|:|..|.|.|.|.|    |.|.||.:  :|......:.|:.| |:.::.|.|..:..|
Human   214 TIIIHANASMSHTIL----LKAAELGM--VSAYYTYIFTNLEFSLQRMDSLVDDRVNIL------ 266

  Fly    91 GFITILSQTHHFI----------------HARYYATRNANVRLKDKRYLFLC-------EDESPA 132
            || :|.:|:|.|.                |..:.....::..|.|..|..:.       ..|...
Human   267 GF-SIFNQSHAFFQEFAQSLNQSWQENCDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGV 330

  Fly   133 ELLCMDILQFYPHHLMVRPGTETAPTGPTGPHPDPRRGGGASVSTKNKDDGEGGAGN-KTTSPYR 196
            :.|.....|.:.|                         |.:.::.....:.||..|: :..|..:
Human   331 KPLSCGSAQIWQH-------------------------GTSLMNYLRMVELEGLTGHIEFNSKGQ 370

  Fly   197 DINFELWTQKF-------VGAVGNLDALLLDAFLPNETFANRVELYPNKLLNLQRRSLLVGSITY 254
            ..|:.|...:|       :|.....:.|.:|:.|    :|:.:.   :.|.|   .:|:|.:|..
Human   371 RSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHL----YASNIS---DTLFN---TTLVVTTILE 425

  Fly   255 VPYTITNYVPAGQGDVDPIHPQWPNRSLTFDGAEANVMKTFCQVHNCHLRVEAYGADNWGGIYDN 319
            .||.:.      :|:    |.:..... .::|...:::|...::...:.::...|...:|....|
Human   426 NPYLML------KGN----HQEMEGND-RYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEAN 479

  Fly   320 ESSDGMLGDIYEQRVEMAIGCIYNWYDGITETSH-----TIARSSVTI---------LGPAPAPL 370
            .:..||:|::..::.::|:.       |:|.|:.     ..::..:|:         :|..
Human   480 GTWTGMVGELIARKADLAVA-------GLTITAEREKVIDFSKPFMTLGISILYRVHMGRK---- 533

  Fly   371 PSWRTNIMPFNNRAWLVLISTLVICGTFLYFMKYVSYRLRYS------GTQVKFHHSRKLEKSML 429
            |.:.:.:.||:...||.::...:.....|:.:..::....||      |......:...|..|:.
Human   534 PGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLW 598

  Fly   430 DIFALFIQQPSAPLSFDRFAPRFFLATILCA-----TITLENIYSGQLKSMLTFPFYSAPVDTIE 489
            .....|:||.|.      .|||......:..     |:.:.:.|:..|.:.||......|:::::
Human   599 FPVGGFMQQGST------IAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVD 657

  Fly   490 KWA---------------------------QSGWKW---SAPSIIWVHTVQSSDLETEQILARNF 524
            ..|                           |..|.:   ..||:.    |:|::....::|..|:
Human   658 DLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVF----VKSTEEGIARVLNSNY 718

  Fly   525 ------EVHDYSYLSNVS------FMPNYGFGIERLSSGSLSVGDYVSTEALENRIVLHDDLYFD 577
                  .:::|....|.:      .:...|:||      .:.||.           |..|:  ||
Human   719 AFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGI------GMPVGS-----------VFRDE--FD 764

  Fly   578 YTRAVSIRGWILMPELNKHIRTCQETGLYFHWELEFIDKYMDKKKQEVLMDLANGHKVKGAPQAL 642
            ..        ||..:.|..:...:..    .||.....|..|             |:.||    |
Human   765 LA--------ILQLQENNRLEILKRK----WWEGGKCPKEED-------------HRAKG----L 800

  Fly   643 DVRNIAGALFVLAFGVAFAGCALVAELL 670
            .:.||.|...||..|:..|....:.|.|
Human   801 GMENIGGIFVVLICGLIVAIFMAMLEFL 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir92a	NP_001097845.2	None
GRIK4	NP_001269399.1	PBP1_iGluR_Kainate_KA1_2	26..400	CDD:107389	42/223 (19%)
		ANF_receptor	43..382	CDD:279440	39/205 (19%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	69/435 (16%)
		Lig_chan	547..816	CDD:278489	57/326 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..889
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155777
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840