Protein Alignment Ir92a and GRIK3

DIOPT Version :9

• Sequence 1: NP_001097845.2
• Gene: Ir92a / 42415
• FlyBaseID: FBgn0038789
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_000822.2
• Gene: GRIK3 / 2899
• HGNCID: 4581
• Length: 919
• Species: Homo sapiens
• Alignment Length: 788
• Identity: 159/788 - (20%)
• Similarity: 277/788 - (35%)
• Gaps: 215/788 - (27%)

  Fly     3 LQPLVMHLSQLLRIIVGQYFAEFPSILIVYNNSASTTPLQLEYLSA-----LELVLREL------ 56
            |.|....||..:..:| ||. ::.|..:||::|.....|| |.:.|     :.|.:|:|
Human   152 LYPDYASLSHAILDLV-QYL-KWRSATVVYDDSTGLIRLQ-ELIMAPSRYNIRLKIRQLPIDSDD 213

  Fly    57 SKPIRLQWINVAFLKDLNDLED--------QVMGA--LNSSVTEGFITILSQTHHFIHAR--YYA 109
            |:|:         ||::....:        ..|.|  |..::..|.:|   :.:|||...  .||
Human   214 SRPL---------LKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMT---EYYHFIFTTLDLYA 266

  Fly   110 T-----RNANVRLKDKRYLFLCEDESP-----AELLCMDILQFYPH------------------- 145
            .     |.:.|.|...|.|.:   ::|     .|...|:.||..|.
Human   267 LDLEPYRYSGVNLTGFRILNV---DNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAALLYD 328

  Fly   146 --HLMVRPGTETAPTGPTGPHPDPR----RGGGASVSTKNKDDGEGGAG----NKTTSPYRDINF 200
              |: |....:.||..........|    |.||..::...:...||..|    |||:....|.:.
Human   329 AVHI-VSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDL 392

  Fly   201 ELWTQK-----FVGAVGNLDALLLDAFLPNETFANRVELYPNKLLNLQRRSLLVGSITYVPYTIT 260
            ::.:.|     .||.....|.|.:     .|....|   .||...:|..|||:|.::...|:.:.
Human   393 DIISLKEDGLEKVGVWSPADGLNI-----TEVAKGR---GPNVTDSLTNRSLIVTTVLEEPFVMF 449

  Fly   261 NYVPAGQGDVDPIHPQWPNRSL----TFDGAEANVMKTFCQVHNCHLRVEAYGADNWGGIYDNES 321
                           :..:|:|    .|:|...:::|....:......:.......:|...|...
Human   450 ---------------RKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQ 499

  Fly   322 SDGMLGDIYEQRVEMAIG--CIYNWYDGITETSHTIARSSVTILGPAP-APLPSWRTNIMPFNNR 383
            .:||:.::.:.:.::|:.  .|.:..:...:.|.......|:||...| ...||..:.:.|.:..
Human   500 WNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPD 564

  Fly   384 AWL-VLISTL-VICGTFLY--FMKYVSYRLR--YSGTQVKFHHSRKLEKSMLDIFALFIQQPSAP 442
            .|: ||::.| |.|..|:.  |..|..|...  ..|::|..::...|......:.:| :||.|
Human   565 IWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSL-MQQGS-- 626

  Fly   443 LSFDRFAPRFFLATILCA-----TITLENIYSGQLKSMLTFPFYSAPVDTIEKWA-QSGWKWSAP 501
                ...|:.....|:..     |:.:.:.|:..|.:.||.....:|:|:.:..| |:..::.|.
Human   627 ----ELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAV 687

  Fly   502 SIIWVHT-VQSSDLETEQILARNFEVHDYSYLSN--VSFMPNYGFGIERLSSGSLSVGDYVSTEA 563
            ......| .:.|.:.|.:.:        ::::|:  .:.:.|...||:|..:     .||.
Human   688 KDGATMTFFKKSKISTFEKM--------WAFMSSKPSALVKNNEEGIQRALT-----ADYA---- 735

  Fly   564 LENRIVLHDDLYFDYTRAVSIRGWILMPELNKHIRTCQET---GLYFHWELEFIDK--------- 616
                 :|.:....:|...                |.|..|   ||        ||.
Human   736 -----LLMESTTIEYVTQ----------------RNCNLTQIGGL--------IDSKGYGIGTPM 771

  Fly   617 ---YMDKKKQEVLM----DLANGHKVK-----GAPQ-------ALDVRNIAGALFVLAFGVAFAG 662
               |.||....:|.    |..:..|.|     |.|:       ||.::.|.|...|||.|:..:.
Human   772 GSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSV 836

  Fly   663 CALVAELL 670
            ...|.|.:
Human   837 LVAVGEFV 844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir92a	NP_001097845.2	None
GRIK3	NP_000822.2	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	63/288 (22%)
		ANF_receptor	55..398	CDD:279440	58/264 (22%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	79/435 (18%)
		Lig_chan	564..832	CDD:278489	64/320 (20%)
		Glutamate binding. /evidence=ECO:0000250	690..692		0/1 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156185
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840