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Protein Alignment Ir92a and GRIK2

DIOPT Version :9

Sequence 1:	NP_001097845.2	Gene:	Ir92a / 42415	FlyBaseID:	FBgn0038789	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_068775.1	Gene:	GRIK2 / 2898	HGNCID:	4580	Length:	908	Species:	Homo sapiens

Alignment Length:	800	Identity:	152/800 - (19%)
Similarity:	268/800 - (33%)	Gaps:	237/800 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LQPLVMHLSQLLRIIVGQYFAEFPSILIVYNNSASTTPLQLEYLSA-----LELVLREL------ 56
            |.|....||:.:..:| |:| ::.::.:||::|.....|| |.:.|     |.|.:|:|
Human   149 LYPDFSSLSRAILDLV-QFF-KWKTVTVVYDDSTGLIRLQ-ELIKAPSRYNLRLKIRQLPADTKD 210

  Fly    57 SKPI-----RLQWINVAFLKDLNDLEDQVMGALNSSVTEGFITILSQTHHFIHA----------- 105
            :||:     |.:..:|.|  |.:  .:...|.|..::..|.:|   :.:|:|..
Human   211 AKPLLKEMKRGKEFHVIF--DCS--HEMAAGILKQALAMGMMT---EYYHYIFTTLDLFALDVEP 268

  Fly   106 -RYYATRNANVRLKDKRYLFLCEDESPAELLCMDILQFYPHHLMVRPGTETAPTGPTGPHPD--- 166
             ||........|:.:...   .:..|..|...|:.||              ||     |.||
Human   269 YRYSGVNMTGFRILNTEN---TQVSSIIEKWSMERLQ--------------AP-----PKPDSGL 311

  Fly   167 ----------------------------------------PRRGGGASVSTKNKDDGEGGAG--- 188
                                                    |.|.|...:|...:...||..|
Human   312 LDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRIT 376

  Fly   189 -NKTTSPYRDINFELWTQKFVG--AVGNLDALLLDAFLPNETFANRVELYPNKLLN----LQRRS 246
             |||.....|.:.::.:.|..|  .:|..|.         .:..|..|....|..|    |..||
Human   377 FNKTNGLRTDFDLDVISLKEEGLEKIGTWDP---------ASGLNMTESQKGKPANITDSLSNRS 432

  Fly   247 LLVGSITYVPYTITNYVPAGQGDVDPIHPQWPNRSLTFDGAEANVMKTFCQVHNCHLRVEAYGAD 311
            |:|.:|...||.:..     :.|    .|.:.|.  .|:|...::::....:......:......
Human   433 LIVTTILEEPYVLFK-----KSD----KPLYGND--RFEGYCIDLLRELSTILGFTYEIRLVEDG 486

  Fly   312 NWGGIYD-NESSDGMLGDIYEQRVEMAIGCIYNWY--DGITETSHTIARSSVTILGPAP-APLPS 372
            .:|...| |...:||:.::.:.:.::|:..:...|  :.:.:.|.......::||...| ...|.
Human   487 KYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPG 551

  Fly   373 WRTNIMPFNNRAWL-VLISTL-VICGTFLY--FMKYVSYRLR--YSGTQVKFHHSRKLEKSMLDI 431
            ..:.:.|.:...|: :|::.| |.|..|:.  |..|..|...  ...:.|..::...|......:
Human   552 VFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGV 616

  Fly   432 FALFIQQPSAPLSFDRFAPRFFLATILCA-----TITLENIYSGQLKSMLTFPFYSAPVDTIEKW 491
            .|| :||.|      ...|:.....|:..     |:.:.:.|:..|.:.||.....:|:|:.:..
Human   617 GAL-MQQGS------ELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDL 674

  Fly   492 AQ------------------SGWKWSAPSIIWVH--------TVQSSDLETEQILARNFEVHDYS 530
            |:                  ...|.|....:|..        .|:|::...:::|     ..||:
Human   675 AKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVL-----TSDYA 734

  Fly   531 YL---SNVSFMPNYGFGIERLSSGSLSVGDYVSTEALENRIVLHDDLYFDYTRAVSIRGWILMPE 592
            :|   :.:.|:......:.::.....|.|..|.|           .:...|...::|.
Human   735 FLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGT-----------PMGSPYRDKITIA------- 781

  Fly   593 LNKHIRTCQETGLYFHWELEFIDKYMDKKKQEVLMDLANGHKVKGAPQ-------ALDVRNIAGA 650
                |...||.|          ..:|.|:|         ..:..|.|:       ||.|:||.|.
Human   782 ----ILQLQEEG----------KLHMMKEK---------WWRGNGCPEEESKEASALGVQNIGGI 823

  Fly   651 LFVLAFGVAFAGCALVAELL 670
            ..|||.|:..:....|.|.|
Human   824 FIVLAAGLVLSVFVAVGEFL 843

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.