Protein Alignment Ir92a and GRIK1

DIOPT Version :10

• Sequence 1: NP_001097845.2
• Gene: Ir92a / 42415
• FlyBaseID: FBgn0038789
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_001317923.1
• Gene: GRIK1 / 2897
• HGNCID: 4579
• Length: 949
• Species: Homo sapiens
• Alignment Length: 809
• Identity: 153/809 - (18%)
• Similarity: 281/809 - (34%)
• Gaps: 241/809 - (29%)

  Fly     3 LQPLVMHLSQLLRIIVGQYFAEFPSILIVYNNSASTTPLQLEYLSA-----LELVLREL------ 56
            |.|....:|:.:..:|..|  .:.::.:||.:|.....|| |.:.|     :::.:|:|
Human   150 LYPDYAAISRAILDLVLYY--NWKTVTVVYEDSTGLIRLQ-ELIKAPSRYNIKIKIRQLPSGNKD 211

  Fly    57 SKPIRLQWINVAFLKDLN---------DLEDQVMGALNSSVTEGFITILSQTHHFIHARYYAT-- 110
            :||:         ||::.         |...:....:...:.  |:.::::.:|:    ::.|
Human   212 AKPL---------LKEMKKGKEFYVIFDCSHETAAEILKQIL--FMGMMTEYYHY----FFTTLD 261

  Fly   111 ---------RNANVRLKDKRYLFLCEDESP-----AELLCMDILQFYPHHLMVRPGTE------- 154
                     |.:.|.:...|.|.:   ::|     .|...|:.||..|     ||.|.
Human   262 LFALDLELYRYSGVNMTGFRLLNI---DNPHVSSIIEKWSMERLQAPP-----RPETGLLDGMMT 318

  Fly   155 -----------------------TAPTGPTGPHPDPRRGGGASVSTKNKDDGEGGAG----NKTT 192
                                   |..:.....| .|.|.|...::...:...:|..|    |||.
Human   319 TEAALMYDAVYMVAIASHRASQLTVSSLQCHRH-KPWRLGPRFMNLIKEARWDGLTGHITFNKTN 382

  Fly   193 SPYRDINFELWTQKFVG---AVGNLDALLLDAFLP----------NETFANRVELYPNKLLNLQR 244
            ...:|.:.::.:.|..|   |.|.:...|...:..          |.|.:|: :...|...:|..
Human   383 GLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNK-DKSSNITDSLAN 446

  Fly   245 RSLLVGSITYVPYTITNYVPAGQGDVDPIHPQWPNRSLTFDGAEANVMKTFCQVHNCHLRVE--- 306
            |:|:|.:|...||.:..     :.|    .|.:.|.  .|:|...:::|....:......|:
Human   447 RTLIVTTILEEPYVMYR-----KSD----KPLYGND--RFEGYCLDLLKELSNILGFIYDVKLVP 500

  Fly   307 --AYGADNWGGIYDNESSDGMLGDIYEQRVEMAIGCIYNWY--DGITETSHTIARSSVTILGPAP 367
              .|||.|     |....:||:.::.:.|.::|:..:...|  :.:.:.|.......::||...|
Human   501 DGKYGAQN-----DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKP 560

  Fly   368 -APLPSWRTNIMPFNNRAWL-VLISTL-VICGTFLY--FMKYVSYRLR--YSGTQVKFHHSRKLE 425
             ...|...:.:.|.:...|: ||::.| |.|..|:.  |..|..|...  ...:.|..::...|.
Human   561 NGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLN 625

  Fly   426 KSMLDIFALFIQQPSAPLSFDRFAPRFFLATILCA-----TITLENIYSGQLKSMLTFPFYSAPV 485
            .....:.|| :||.|      ...|:.....|:..     |:.:.:.|:..|.:.||.....:|:
Human   626 SFWFGVGAL-MQQGS------ELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPI 683

  Fly   486 DTIEKWA-QSGWKWSAPSIIWVHTVQSSDLETEQILARNFEVHDY----SYLSN---VSFMPNYG 542
            |:.:..| |:..::.|        |:.....|   ..:..::..|    :::|:   .:.:.|..
Human   684 DSADDLAKQTKIEYGA--------VRDGSTMT---FFKKSKISTYEKMWAFMSSRQQTALVRNSD 737

  Fly   543 FGIERLSSGSLSVGDYVSTEALENRIVLHDDLYFDYTRAVSIRGWILMPELNKHIRTCQET---G 604
            .||:|:.:     .||.         :|.:....:|...                |.|..|   |
Human   738 EGIQRVLT-----TDYA---------LLMESTSIEYVTQ----------------RNCNLTQIGG 772

  Fly   605 LYFHWELEFIDK------------YMDKKKQEVLMDLANG--HKVK-------GAPQ-------A 641
            |        ||.            |.||....:|.....|  |.:|       |.|:       |
Human   773 L--------IDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASA 829

  Fly   642 LDVRNIAGALFVLAFGVAFAGCALVAELL 670
            |.|.||.|...|||.|:..:....:.|.:
Human   830 LGVENIGGIFIVLAAGLVLSVFVAIGEFI 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir92a	NP_001097845.2	None
GRIK1	NP_001317923.1	PBP1_iGluR_Kainate	38..431	CDD:380605	52/307 (17%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	84/440 (19%)