Protein Alignment Ir92a and GRID1

DIOPT Version :9

• Sequence 1: NP_001097845.2
• Gene: Ir92a / 42415
• FlyBaseID: FBgn0038789
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_060021.1
• Gene: GRID1 / 2894
• HGNCID: 4575
• Length: 1009
• Species: Homo sapiens
• Alignment Length: 644
• Identity: 121/644 - (18%)
• Similarity: 233/644 - (36%)
• Gaps: 166/644 - (25%)

  Fly    90 EGFITILSQTHHFIHARYYATRNA-NVRLKDKRYLFLCEDESPAELLCMDILQFYPHHLMVRPGT 153
            ||::.:|..::.:::.......|| :.:|:|:::      .|.|.|.|            :|..|
Human   310 EGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKW------HSMASLNC------------IRKST 356

  Fly   154 ETAPTGPTGPHPDPRRGGGASVSTKNKDDGEGGAG-----NKTTSPYRDINFELWTQKFVGAVGN 213
            :            |..||.:.:.|..|....|..|     ..:::||  :.||:....:
Human   357 K------------PWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPY--VQFEILGTTY------ 401

  Fly   214 LDALLLDAFLPNETFANRVELY----PNKLLN-----------LQRRSLLVGSITYVPYTITNYV 263
                       :|||...:...    ..|.||           ||..:|.|.::...|:.:....
Human   402 -----------SETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAEN 455

  Fly   264 PAGQGDVDPIHPQWPNRSLTFDGAEANVMKTFCQVHNCHLRVEAYGADN--WGGIYDNESSDGML 326
            ..||          |.|   :.|...:|:....:.  ...:.|.|.|.:  :|....|.|.:||:
Human   456 ILGQ----------PKR---YKGFSIDVLDALAKA--LGFKYEIYQAPDGRYGHQLHNTSWNGMI 505

  Fly   327 GDIYEQRVEMAIGC--IYNWYDGITETSHTIARSSVTILGPAPAPLPSWRTNIMPFNNRAWLVLI 389
            |::..:|.::||..  |....:.:.:.|......||.||...|....|..:...||:...|..:.
Human   506 GELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIA 570

  Fly   390 STLVICGTFLYFMKYVSYRLRYSGTQVKFHHSRKLEKSMLDIFALFIQQPSAPLSFDRFAPRFFL 454
            :.:.:.|..::.:..:......|..|.:...|..|..::..::..|:|| ....|.:..|.|..:
Human   571 AAIPVVGVLIFVLNRIQAVRAQSAAQPRPSASATLHSAIWIVYGAFVQQ-GGESSVNSMAMRIVM 634

  Fly   455 ATILCATITLENIYSGQLKSMLTFPFYSAPVDT---IEKWAQSGWKWSAPSIIWVH--TVQSSDL 514
            .:....|:.:.:.|:..|.:.||......|:.|   :.|..:..:.....|.::.:  ...::.|
Human   635 GSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPL 699

  Fly   515 ETEQILA-----------------------RNFEVHDYSYLSNVSFMPNYGFGIERLSSGSLSV- 555
            |.:...|                       |..:..:|::|.:|:.: .|.    .|:....||
Human   700 EQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVV-EYA----ALTDDDCSVT 759

  Fly   556 --GDYVSTE----ALENRIVLHDDLYFDYTRAVSIRGWILMPELNKHIRTCQETGLYFHWELEFI 614
              |:.:|::    ||:     |...|.|.              .::.|...|:||     :|:.:
Human   760 VIGNSISSKGYGIALQ-----HGSPYRDL--------------FSQRILELQDTG-----DLDVL 800

  Fly   615 DK----YMDKKKQEVLMDLANGHKVKGAPQALDVRNIAGALFVLAFGVAFAGCALVAEL 669
            .:    :|.:      .||.:....:...::|.:.:.||...:||.|:..|  .|||.|
Human   801 KQKWWPHMGR------CDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLA--CLVAAL 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir92a	NP_001097845.2	None
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250|UniProtKB:Q61627	21..436		31/174 (18%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	29/161 (18%)
		ANF_receptor	41..400	CDD:279440	24/121 (20%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	75/414 (18%)
		Lig_chan	564..841	CDD:278489	52/312 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	930..954

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155869
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840