DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir92a and GRIA2

DIOPT Version :9

Sequence 1:NP_001097845.2 Gene:Ir92a / 42415 FlyBaseID:FBgn0038789 Length:678 Species:Drosophila melanogaster
Sequence 2:NP_000817.5 Gene:GRIA2 / 2891 HGNCID:4572 Length:883 Species:Homo sapiens


Alignment Length:808 Identity:153/808 - (18%)
Similarity:277/808 - (34%) Gaps:239/808 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 PLVMHL-----SQLLRIIVGQYFAEFPSILIVYNNSASTTPLQLEYLSALELVLRELSKPIRLQW 64
            |.|:.:     ..||.:|  :|: ::.....:|::....:.||....||.|       |..::..
Human   123 PFVIQMRPDLKGALLSLI--EYY-QWDKFAYLYDSDRGLSTLQAVLDSAAE-------KKWQVTA 177

  Fly    65 INVAFLKDLNDLEDQVMGAL--------------------NSSVTEGFITILSQT--HHFIHARY 107
            |||..:.  ||.:|::..:|                    .:.:.:..|||....  :|:|.|..
Human   178 INVGNIN--NDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANL 240

  Fly   108 YAT---------RNANV---RLKD----------KRYLFLCEDESP---------AELLCMDILQ 141
            ..|         ..|||   ::.|          :|:..|.|.|.|         ...|..|.:|
Human   241 GFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQ 305

  Fly   142 FYPHHL--MVRPGTETAPTGPTG---PHPDPRRGGGASVSTKNKD-DGEGGAGN-KTTSPYRDIN 199
            ......  :.:...|.:..|..|   .:|....|.|..:....|. ..||.:|| |.....:.||
Human   306 VMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRIN 370

  Fly   200 F-----ELWTQ--KFVGAVGNLDALLLD-AFLPNETFANRVELYPNKLLNLQRRSLLVGSITYVP 256
            :     ||.|.  :.:|....:|.:::. ..||:          .|....|:.::::|.:|...|
Human   371 YTINIMELKTNGPRKIGYWSEVDKMVVTLTELPS----------GNDTSGLENKTVVVTTILESP 425

  Fly   257 YTITNYVPAGQGDVDPIHPQWPNRSLTFDGAE----------ANVMKTFCQVHNCHLRVE----- 306
            |.:..                .|..: .:|.|          |.:.|      :|..:.:     
Human   426 YVMMK----------------KNHEM-LEGNERYEGYCVDLAAEIAK------HCGFKYKLTIVG 467

  Fly   307 --AYGADNWGGIYDNESSDGMLGDIYEQRVEMAIGCIYNWYDGITETSHTIARSSVTILGPAPAP 369
              .|||.:    .|.:..:||:|::...:.::||..:          :.|:.|..|....   .|
Human   468 DGKYGARD----ADTKIWNGMVGELVYGKADIAIAPL----------TITLVREEVIDFS---KP 515

  Fly   370 LPSWRTNIM----------------PFNNRAWLVLISTLVICGTFLYFMKYVSYRLRYSGTQVKF 418
            ..|...:||                |.....|:.::...:.....|:.:...|   .|.....:|
Human   516 FMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFS---PYEWHTEEF 577

  Fly   419 HHSRKLEKS-MLDIFALF---------IQQPSAPLSFDRFAPRFFLATILCA-----TITLENIY 468
            ...|:.:.| ..:.|.:|         ..|....:|     ||.....|:..     |:.:.:.|
Human   578 EDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDIS-----PRSLSGRIVGGVWWFFTLIIISSY 637

  Fly   469 SGQLKSMLTFPFYSAPVDTIEKWAQSGWKWSAPSIIWVHTVQSSDLETEQILARN-FEVHD--YS 530
            :..|.:.||.....:|:::.|       ..|..:.|...|:.|.  .|::...|: ..|.|  ::
Human   638 TANLAAFLTVERMVSPIESAE-------DLSKQTEIAYGTLDSG--STKEFFRRSKIAVFDKMWT 693

  Fly   531 YLSNVS---FMPNYGFGIERLSSGSLSVGDYV----ST--EALENR-----IVLHDDLYFDYTRA 581
            |:.:..   |:.....|:.|:..   |.|.|.    ||  |.:|.|     :.:..:|.......
Human   694 YMRSAEPSVFVRTTAEGVARVRK---SKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGI 755

  Fly   582 VSIRGWILMPELNKHIRTCQETGLYFHWELEFIDKYMDKKKQEVLMDLAN-GHKVKGAPQ---AL 642
            .:.:|..|...:|..:....|.|:            :||.|.:...|... |.|..|:.:   ||
Human   756 ATPKGSSLRTPVNLAVLKLSEQGV------------LDKLKNKWWYDKGECGAKDSGSKEKTSAL 808

  Fly   643 DVRNIAGALFVLAFGVAFAGCALVAELL 670
            .:.|:||..::|..|:   |.|::..|:
Human   809 SLSNVAGVFYILVGGL---GLAMLVALI 833

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir92aNP_001097845.2 None
GRIA2NP_000817.5 PBP1_iGluR_AMPA_GluR2 28..398 CDD:380612 58/286 (20%)
PBP2_iGluR_AMPA 413..794 CDD:270433 78/452 (17%)
Glutamate binding 499..501 0/11 (0%)