Protein Alignment Ir92a and GRIA1

DIOPT Version :9

• Sequence 1: NP_001097845.2
• Gene: Ir92a / 42415
• FlyBaseID: FBgn0038789
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_001244950.1
• Gene: GRIA1 / 2890
• HGNCID: 4571
• Length: 916
• Species: Homo sapiens
• Alignment Length: 610
• Identity: 110/610 - (18%)
• Similarity: 194/610 - (31%)
• Gaps: 225/610 - (36%)

  Fly   185 GGAGNKTTSPY------RDINFELWTQKFVGAVGNL--------------------DALLL---- 219
            |.||:...:|.      .||...|...:|.|..||:                    |.:..
Human   328 GNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYW 392

  Fly   220 ---DAFLPNETFANRVELYPNKLLNLQRRSLLVGSITYVPYTITNYVPAGQGDVDPIHPQWPNRS 281
               |.|:|..|.|..    .....::|.|:.:|.:|...||.:..                 ..:
Human   393 NEDDKFVPAATDAQA----GGDNSSVQNRTYIVTTILEDPYVMLK-----------------KNA 436

  Fly   282 LTFDGAE----------ANVMKTFCQVHNCHL----RVE-----AYGADNWGGIYDNESSDGMLG 327
            ..|:|.:          |.:.|        |:    |:|     .|||.:    .|.::.:||:|
Human   437 NQFEGNDRYEGYCVELAAEIAK--------HVGYSYRLEIVSDGKYGARD----PDTKAWNGMVG 489

  Fly   328 DIYEQRVEMAIGCIYNWYDGITETSHTIARSSVTILGPAPAPLPSWRTNIM-------------- 378
            ::...|.::|:..:          :.|:.|..|....   .|..|...:||
Human   490 ELVYGRADVAVAPL----------TITLVREEVIDFS---KPFMSLGISIMIKKPQKSKPGVFSF 541

  Fly   379 --PFNNRAWLVLISTLVICGTFLYFMKYVSYRLRYSGTQVKFHHSRKLEK--------------- 426
              |.....|:.::...:.....|:.:.      |:|..:   .||.:.|:
Human   542 LDPLAYEIWMCIVFAYIGVSVVLFLVS------RFSPYE---WHSEEFEEGRDQTTSDQSNEFGI 597

  Fly   427 --SMLDIFALFIQQPSAPLSFDRFAPRFFLATILCA-----TITLENIYSGQLKSMLTFPFYSAP 484
              |:......|:||..      ..:||.....|:..     |:.:.:.|:..|.:.||.....:|
Human   598 FNSLWFSLGAFMQQGC------DISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSP 656

  Fly   485 VDTIEKWA----------QSG-----------------WKW--SAPSIIWVHTVQSSDLETEQIL 520
            :::.|..|          ::|                 |.:  ||...::|.|.:...:...:..
Human   657 IESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSK 721

  Fly   521 ARNFEVHDYSYLSNVSFMPNYGFGIE-RLSSGSLSVGDYVSTEALENRIVLHDDLYFDYTRAVSI 584
            .:      |:||.. |.|..|   || |....::.||..:.::.              |..|..
Human   722 GK------YAYLLE-STMNEY---IEQRKPCDTMKVGGNLDSKG--------------YGIATP- 761

  Fly   585 RGWILMPELNKHIRTCQETGLYFHWELEFIDKYMDKKKQEVLMDL----ANGHKVKGAPQALDVR 645
            :|..|...:|..:....|.||            :||.|.:...|.    :.|...|....||.:.
Human   762 KGSALRNPVNLAVLKLNEQGL------------LDKLKNKWWYDKGECGSGGGDSKDKTSALSLS 814

  Fly   646 NIAGALFVLAFGVAFAGCALVAELL 670
            |:||..::|..|:   |.|::..|:
Human   815 NVAGVFYILIGGL---GLAMLVALI 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir92a	NP_001097845.2	None
GRIA1	NP_001244950.1	PBP1_iGluR_AMPA_GluR1	36..399	CDD:107385	13/70 (19%)
		ANF_receptor	47..382	CDD:279440	11/53 (21%)
		PBP2_iGluR_AMPA_GluR1	416..797	CDD:270447	80/474 (17%)
		Lig_chan	548..827	CDD:278489	59/330 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156058
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840