DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir92a and Grik4

DIOPT Version :9

Sequence 1:	NP_001097845.2	Gene:	Ir92a / 42415	FlyBaseID:	FBgn0038789	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_036704.1	Gene:	Grik4 / 24406	RGDID:	2734	Length:	956	Species:	Rattus norvegicus

Alignment Length:	745	Identity:	132/745 - (17%)
Similarity:	248/745 - (33%)	Gaps:	231/745 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SILIVYNNSASTTPLQLEYLSALELVLRELSKPIRLQWINVAF-LKDLNDLEDQVMGALNSSVTE 90
            :|:|..|.|.|.|.|    |.|.||.:  :|......:.|:.| |:.::.|.|..:..|
  Rat   214 TIIIHANASMSHTIL----LKAAELGM--VSAYYTYIFTNLEFSLQRMDSLVDDRVNIL------ 266

  Fly    91 GFITILSQTHHFI----------------HARYYATRNANVRLKDKRYLFLC-------EDESPA 132
            || :|.:|:|.|.                |..:.....::..|.|..|..:.       ..|...
  Rat   267 GF-SIFNQSHAFFQEFSQSLNQSWQENCDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGV 330

  Fly   133 ELLCMDILQFYPHHLMVRPGTETAPTGPTGPHPDPRRGGGASVSTKNKDDGEGGAGN-KTTSPYR 196
            :.|.....|.:.|                         |.:.::.....:.||..|: :..|..:
  Rat   331 KPLSCGSAQIWQH-------------------------GTSLMNYLRMVELEGLTGHIEFNSKGQ 370

  Fly   197 DINFELWTQKF-------VGAVGNLDALLLDAFLPNETFANRVELYPNKLLNLQRRSLLVGSITY 254
            ..|:.|...:|       :|.....:.|.:|:.|    :|:.:.   :.|.|   .:|:|.:|..
  Rat   371 RSNYALKILQFTRNGFRQIGQWHVAEGLSMDSRL----YASNIS---DSLFN---TTLVVTTILE 425

  Fly   255 VPYTIT--NYVPAGQGDVDPIHPQWPNRSLTFDGAEANVMKTFCQVHNCHLRVEAYGADNWGGIY 317
            .||.:.  |:......|             .::|...:::|...::...:.::...|...:|...
  Rat   426 NPYLMLKGNHQDMEGND-------------RYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPE 477

  Fly   318 DNESSDGMLGDIYEQRVEMAIGCIYNWYDGITETSH-----TIARSSVTI---------LGPAPA 368
            .|.:..||:|::..::.::|:.       |:|.|:.     ..::..:|:         :|..
  Rat   478 ANGTWTGMVGELIARKADLAVA-------GLTITAEREKVIDFSKPFMTLGISILYRVHMGRR-- 533

  Fly   369 PLPSWRTNIMPFNNRAWLVLISTLVICGTFLYFMKYVSYRLRYS------GTQVKFHHSRKLEKS 427
              |.:.:.:.||:...||.::...:.....|:.:..::....||      |......:...|..|
  Rat   534 --PGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNS 596

  Fly   428 MLDIFALFIQQPSAPLSFDRFAPRFFLATILCA-----TITLENIYSGQLKSMLTFPFYSAPVDT 487
            :......|:||.|.      .|||......:..     |:.:.:.|:..|.:.||......|:::
  Rat   597 LWFPVGGFMQQGST------IAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIES 655

  Fly   488 IEKWA---------------------------QSGWKW---SAPSIIWVHTVQSSDLETEQILAR 522
            ::..|                           |..|.:   ..||:.    |:|::....::|..
  Rat   656 VDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVF----VKSTEEGIARVLNS 716

  Fly   523 NF------EVHDYSYLSNVS------FMPNYGFGIERLSSGSLSVGDYVSTEALENRIVLHDDLY 575
            |:      .:::|....|.:      .:...|:||      .:.||.           |..|:
  Rat   717 NYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGI------GMPVGS-----------VFRDE-- 762

  Fly   576 FDYTRAVSIRGWILMPELNKHIRTCQETGLYFHWELEFIDKYMDKKKQEVLMDLANGHKVKGAPQ 640
            ||..        ||..:.|..:...:..    .||.....|..|             |:.||
  Rat   763 FDLA--------ILQLQENNRLEILKRK----WWEGGKCPKEED-------------HRAKG--- 799

  Fly   641 ALDVRNIAGALFVLAFGVAFAGCALVAELL 670
             |.:.||.|...||..|:..|....:.|.|
  Rat   800 -LGMENIGGIFVVLICGLIVAIFMAMLEFL 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir92a	NP_001097845.2	None
Grik4	NP_036704.1	Periplasmic_Binding_Protein_type1	24..402	CDD:415822	42/225 (19%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	69/437 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349683
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840