Protein Alignment Ir92a and Grin3a

DIOPT Version :10

• Sequence 1: NP_001097845.2
• Gene: Ir92a / 42415
• FlyBaseID: FBgn0038789
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_001263284.1
• Gene: Grin3a / 242443
• MGIID: 1933206
• Length: 1135
• Species: Mus musculus
• Alignment Length: 819
• Identity: 153/819 - (18%)
• Similarity: 261/819 - (31%)
• Gaps: 316/819 - (38%)

  Fly    27 SILIVYNNSASTTPLQLEYLSALELVLR-----------------------ELS-----KPIRLQ 63
            ||:.:..|.:||..|    ||.|::.|.                       |:|     .|..|.
Mouse   293 SIINITANLSSTKDL----LSFLQVQLENIRNSTPTMVMFGCDMGSIRQIFEMSTQFGLSPPDLH 353

  Fly    64 WINVAFLKDLNDLEDQ----------VMGALNSSVTEGFITILSQTHHFIHARYYATRNANVRLK 118
            |:    |.|..::|:.          ..|....||.|.::    |....:.||..||..
Mouse   354 WV----LGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYV----QDAMELVARAVATAT------ 404

  Fly   119 DKRYLFLCEDE---SPAELLCMDIL-------QFYPHHLMVRPGTETAPTGPTGPHPDPRRGGGA 173
                  :.:.|   .|:.:.|||:.       |:....|     ..|...|.:|   ..:..|..
Mouse   405 ------MIQPELALLPSTMNCMDVKTTNLTSGQYLSRFL-----ANTTFRGLSG---SIKVKGST 455

  Fly   174 SVSTKNKDDGEGGAGNKTTSPYRDINFELWTQKF--VG-----AVGNLDA--LLLDAFL-PNETF 228
            .||::|                   ||.:|..::  :|     .:|:...  :::|:.: |.:..
Mouse   456 IVSSEN-------------------NFFIWNLQYDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQ 501

  Fly   229 ANRVEL-YPNKLLNLQRRSLLVGSITYVPYTITNYV------PAGQGDVDPIHPQWPNRSLTFDG 286
            .::... :||||      .|.|.::...|:..|..|      ||||..:||:    .|.|...|
Mouse   502 RHKTHFHHPNKL------HLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPM----TNDSSILD- 555

  Fly   287 AEANVMKTFCQVHNCHLRVE------AYG----------------------ADNWGGIYDNESSD 323
                  ..|..:|:.:..|.      .||                      .|...|.:.|....
Mouse   556 ------SLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWT 614

  Fly   324 GMLGDIYEQRVEMAIGCIYNWYDGITETSHTIARSSV---------TILG------PAPAPLPSW 373
            |::||:......||          :|..|...|||.|         |.||      ...||:.::
Mouse   615 GLVGDLLSGTANMA----------VTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAF 669

  Fly   374 RTNIMPFNNRAWLVLISTLVICGTFLYFMKY------------------------VSYRLRYSGT 414
               :.|.:...||.:...|.|...||...::                        |.|.|.:..|
Mouse   670 ---MWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRT 731

  Fly   415 QVKFHHSRKLEKSMLDIFALFIQQPSAPLSFDRFAPRFFLATI---LCATITLENIY---SGQLK 473
            ...........:.:::::|:|..              |.|:|.   |.|.:..|.||   ||...
Mouse   732 AAIKPPKCWTGRFLMNLWAIFCM--------------FCLSTYTANLAAVMVGEKIYEELSGIHD 782

  Fly   474 SMLTFPFYSAPVDTIEKWAQSGWKWSAPSIIWVHTVQSSDLETEQILARNF-EVHDYSYLSNVSF 537
            ..|..|             ..|:::.        ||:.|  ..|..:.::| |:|:|....||..
Mouse   783 PKLHHP-------------SQGFRFG--------TVRES--SAEDYVRQSFPEMHEYMRRYNVPA 824

  Fly   538 MPNYGFGIERLSSGSLSVGDYVSTEALENRIVLHDDLYFDYTRAV-------------SIRGW-I 588
            .|:   |::.|.:....:..::..:||           .||..::             :|.|: |
Mouse   825 TPD---GVQYLKNDPEKLDAFIMDKAL-----------LDYEVSIDADCKLLTVGKPFAIEGYGI 875

  Fly   589 LMP---ELNKHIRTCQETGLYFHWELEFIDKYMDKKKQEVLMDLANGHKVKGAP----------- 639
            .:|   .|..:|.             |.|.:|    |....||:.:....|..|
Mouse   876 GLPPNSPLTSNIS-------------ELISQY----KSHGFMDVLHDKWYKVVPCGKRSFAVTET 923

  Fly   640 QALDVRNIAGALFVLAFGVAFAGCALVAELLIHRMDLSK 678
            ..:.:::.:|...:|..|...:....:.|.:::|:.|.:
Mouse   924 LQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPR 962

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir92a	NP_001097845.2	None
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	40..496	CDD:380600	47/253 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..118
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	95/493 (19%)
		Lig_chan	674..941	CDD:459656	58/334 (17%)
		PPP2CB binding site. /evidence=ECO:0000250|UniProtKB:Q9R1M7	951..987		3/12 (25%)
		GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7	1082..1115