DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir92a and Grin3a

DIOPT Version :9

Sequence 1:	NP_001097845.2	Gene:	Ir92a / 42415	FlyBaseID:	FBgn0038789	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001263284.1	Gene:	Grin3a / 242443	MGIID:	1933206	Length:	1135	Species:	Mus musculus

Alignment Length:	819	Identity:	153/819 - (18%)
Similarity:	261/819 - (31%)	Gaps:	316/819 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SILIVYNNSASTTPLQLEYLSALELVLR-----------------------ELS-----KPIRLQ 63
            ||:.:..|.:||..|    ||.|::.|.                       |:|     .|..|.
Mouse   293 SIINITANLSSTKDL----LSFLQVQLENIRNSTPTMVMFGCDMGSIRQIFEMSTQFGLSPPDLH 353

  Fly    64 WINVAFLKDLNDLEDQ----------VMGALNSSVTEGFITILSQTHHFIHARYYATRNANVRLK 118
            |:    |.|..::|:.          ..|....||.|.::    |....:.||..||..
Mouse   354 WV----LGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYV----QDAMELVARAVATAT------ 404

  Fly   119 DKRYLFLCEDE---SPAELLCMDIL-------QFYPHHLMVRPGTETAPTGPTGPHPDPRRGGGA 173
                  :.:.|   .|:.:.|||:.       |:....|     ..|...|.:|   ..:..|..
Mouse   405 ------MIQPELALLPSTMNCMDVKTTNLTSGQYLSRFL-----ANTTFRGLSG---SIKVKGST 455

  Fly   174 SVSTKNKDDGEGGAGNKTTSPYRDINFELWTQKF--VG-----AVGNLDA--LLLDAFL-PNETF 228
            .||::|                   ||.:|..::  :|     .:|:...  :::|:.: |.:..
Mouse   456 IVSSEN-------------------NFFIWNLQYDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQ 501

  Fly   229 ANRVEL-YPNKLLNLQRRSLLVGSITYVPYTITNYV------PAGQGDVDPIHPQWPNRSLTFDG 286
            .::... :||||      .|.|.::...|:..|..|      ||||..:||:    .|.|...|
Mouse   502 RHKTHFHHPNKL------HLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPM----TNDSSILD- 555

  Fly   287 AEANVMKTFCQVHNCHLRVE------AYG----------------------ADNWGGIYDNESSD 323
                  ..|..:|:.:..|.      .||                      .|...|.:.|....
Mouse   556 ------SLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWT 614

  Fly   324 GMLGDIYEQRVEMAIGCIYNWYDGITETSHTIARSSV---------TILG------PAPAPLPSW 373
            |::||:......||          :|..|...|||.|         |.||      ...||:.::
Mouse   615 GLVGDLLSGTANMA----------VTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAF 669

  Fly   374 RTNIMPFNNRAWLVLISTLVICGTFLYFMKY------------------------VSYRLRYSGT 414
               :.|.:...||.:...|.|...||...::                        |.|.|.:..|
Mouse   670 ---MWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRT 731

  Fly   415 QVKFHHSRKLEKSMLDIFALFIQQPSAPLSFDRFAPRFFLATI---LCATITLENIY---SGQLK 473
            ...........:.:::::|:|..              |.|:|.   |.|.:..|.||   ||...
Mouse   732 AAIKPPKCWTGRFLMNLWAIFCM--------------FCLSTYTANLAAVMVGEKIYEELSGIHD 782

  Fly   474 SMLTFPFYSAPVDTIEKWAQSGWKWSAPSIIWVHTVQSSDLETEQILARNF-EVHDYSYLSNVSF 537
            ..|..|             ..|:::.        ||:.|  ..|..:.::| |:|:|....||..
Mouse   783 PKLHHP-------------SQGFRFG--------TVRES--SAEDYVRQSFPEMHEYMRRYNVPA 824

  Fly   538 MPNYGFGIERLSSGSLSVGDYVSTEALENRIVLHDDLYFDYTRAV-------------SIRGW-I 588
            .|:   |::.|.:....:..::..:||           .||..::             :|.|: |
Mouse   825 TPD---GVQYLKNDPEKLDAFIMDKAL-----------LDYEVSIDADCKLLTVGKPFAIEGYGI 875

  Fly   589 LMP---ELNKHIRTCQETGLYFHWELEFIDKYMDKKKQEVLMDLANGHKVKGAP----------- 639
            .:|   .|..:|.             |.|.:|    |....||:.:....|..|
Mouse   876 GLPPNSPLTSNIS-------------ELISQY----KSHGFMDVLHDKWYKVVPCGKRSFAVTET 923

  Fly   640 QALDVRNIAGALFVLAFGVAFAGCALVAELLIHRMDLSK 678
            ..:.:::.:|...:|..|...:....:.|.:::|:.|.:
Mouse   924 LQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPR 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir92a	NP_001097845.2	None
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	47/254 (19%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	95/493 (19%)
		Lig_chan	676..942	CDD:278489	58/333 (17%)
		PPP2CB binding site. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	951..987		3/12 (25%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846521
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930