DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir92a and Grin3a

DIOPT Version :9

Sequence 1:	NP_001097845.2	Gene:	Ir92a / 42415	FlyBaseID:	FBgn0038789	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_612555.1	Gene:	Grin3a / 191573	RGDID:	621704	Length:	1135	Species:	Rattus norvegicus

Alignment Length:	792	Identity:	146/792 - (18%)
Similarity:	258/792 - (32%)	Gaps:	291/792 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 NNSASTTPLQLEYLSALELV--LRELS-----KPIRLQWINVAFLKDLNDLEDQ----------V 80
            :|..::||..:.:...::.:  :.|:|     .|..|.|:    |.|..::|:.          .
  Rat   316 DNIRNSTPTMVMFGCDMDSIRQIFEMSTQFGLSPPELHWV----LGDSQNVEELRTEGLPLGLIA 376

  Fly    81 MGALNSSVTEGFITILSQTHHFIHARYYATRNANVRLKDKRYLFLCEDE---SPAELLCMDIL-- 140
            .|....||.|.::    |....:.||..||..            :.:.|   .|:.:.|||:.
  Rat   377 HGKTTQSVFEYYV----QDAMELVARAVATAT------------MIQPELALLPSTMNCMDVKTT 425

  Fly   141 -----QFYPHHLMVRPGTETAPTGPTGPHPDPRRGGGASVSTKNKDDGEGGAGNKTTSPYRDINF 200
                 |:....|     ..|...|.:|   ..:..|...:|::|                   ||
  Rat   426 NLTSGQYLSRFL-----ANTTFRGLSG---SIKVKGSTIISSEN-------------------NF 463

  Fly   201 ELWTQKF--VG-----AVGNLDA--LLLDAFL-PNETFANRVEL-YPNKLLNLQRRSLLVGSITY 254
            .:|..:.  :|     .:|:...  :::|:.: |.:...::... :||||      .|.|.::..
  Rat   464 FIWNLQHDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFQHPNKL------HLRVVTLIE 522

  Fly   255 VPYTITNYV------PAGQGDVDPIHPQWPNRSLTFDGAEANVMKTFCQVHNCHLRVE------A 307
            .|:..|..|      ||||..:||:    .|.|...|       :.|..:|:.:..|.      .
  Rat   523 HPFVFTREVDDEGLCPAGQLCLDPM----TNDSSMLD-------RLFSSLHSSNDTVPIKFKKCC 576

  Fly   308 YG----------------------ADNWGGIYDNESSDGMLGDIYEQRVEMAIGCIYNWYDGITE 350
            ||                      .|...|.:.|....|::||:......||          :|.
  Rat   577 YGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGTANMA----------VTS 631

  Fly   351 TSHTIARSSV---------TILG------PAPAPLPSWRTNIMPFNNRAWLVLISTLVICGTFLY 400
            .|...|||.|         |.||      ...||:.::   :.|.:...||.:...|.|...||.
  Rat   632 FSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAF---MWPLHWTMWLGIFVALHITAIFLT 693

  Fly   401 FMKY------------------------VSYRLRYSGTQVKFHHSRKLEKSMLDIFALFIQQPSA 441
            ..::                        |.|.|.:..|...........:.:::::|:|..
  Rat   694 LYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCM---- 754

  Fly   442 PLSFDRFAPRFFLATI---LCATITLENIY---SGQLKSMLTFPFYSAPVDTIEKWAQSGWKWSA 500
                      |.|:|.   |.|.:..|.||   ||.....|..|             ..|:::.
  Rat   755 ----------FCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHP-------------SQGFRFG- 795

  Fly   501 PSIIWVHTVQSSDLETEQILARNF-EVHDYSYLSNVSFMPNYGFGIERLSSGSLSVGDYVSTEAL 564
                   ||:.|  ..|..:.::| |:|:|....||...|:   |::.|.:....:..::..:||
  Rat   796 -------TVRES--SAEDYVRQSFPEMHEYMRRYNVPATPD---GVQYLKNDPEKLDAFIMDKAL 848

  Fly   565 ENRIVLHDDLYFDYTRAV-------------SIRGW-ILMP---ELNKHIRTCQETGLYFHWELE 612
                       .||..::             :|.|: |.:|   .|..:|.             |
  Rat   849 -----------LDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNIS-------------E 889

  Fly   613 FIDKYMDKKKQEVLMDLANGHKVKGAP-----------QALDVRNIAGALFVLAFGVAFAGCALV 666
            .|.:|    |....||:.:....|..|           ..:.:::.:|...:|..|...:....:
  Rat   890 LISQY----KSHGFMDVLHDKWYKVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTI 950

  Fly   667 AELLIHRMDLSK 678
            .|.::||:.|.:
  Rat   951 GEHIVHRLLLPR 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir92a	NP_001097845.2	None
Grin3a	NP_612555.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	39/227 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..117
		ANF_receptor	127..469	CDD:279440	36/199 (18%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	95/493 (19%)
		Lig_chan	676..942	CDD:278489	58/333 (17%)
		PPP2CB binding site	951..987		4/12 (33%)
		GIT1-binding. /evidence=ECO:0000269\|PubMed:24297929	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350017
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930