DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir92a and Grin3b

DIOPT Version :9

Sequence 1:	NP_001097845.2	Gene:	Ir92a / 42415	FlyBaseID:	FBgn0038789	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_579842.2	Gene:	Grin3b / 170796	RGDID:	621705	Length:	1002	Species:	Rattus norvegicus

Alignment Length:	836	Identity:	170/836 - (20%)
Similarity:	287/836 - (34%)	Gaps:	257/836 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LRIIVGQYFA---EFPSILI----VYNNSASTTP--LQLEYLSALELVLRELSKPIRLQ------ 63
            ||::  |:.|   |.|.:.:    |.....:.||  |||::.|.||.:|..|...:|..
  Rat   113 LRLL--QFLAAATETPVVSVLRREVRTALGAPTPFHLQLDWASPLETILDVLVSLVRAHAWEDIA 175

  Fly    64 ---------------WINVA-----FLKDLNDLEDQ---------VMGALNSSVTEGFITIL--- 96
                           |.|.|     |:.||:.|:.:         ::|||....|.....:|
  Rat   176 LVLCRVRDPGSLVTLWTNHASQAPKFVLDLSRLDSRNDSLRAGLALLGALEGGGTPVPAAVLLGC 240

  Fly    97 --SQTHHFIHARYYATRNANVRLKDKRYLFLCEDESPAELL-----------------------C 136
              ::.|..:.|.....:            :|.....|||.|                       .
  Rat   241 STARAHEVLEAAPPGPQ------------WLLGTPLPAEALPTTGLPPGVLALGETEQHSLEAVV 293

  Fly   137 MDILQFYPHHL----MVRPGTETAPTGPTGPHPDPRRGGGASVSTK--------NKDDGEGGAGN 189
            .|:::.....|    :|.|  |.|.. |...:.|..:.||:..:.:        ....|..||..
  Rat   294 HDMVELVAQALSSMALVHP--ERALL-PAVVNCDDLKTGGSEATGRTLARFLGNTSFQGRTGAVW 355

  Fly   190 KTTSPYRDI--NFELWTQKF--VGA-----VGNLDALLLDAFLPNETFANRVELYPNKLLNLQRR 245
            .|.|....:  :|::|:.:.  :||     ||:.....|| |.|... |.||   |:......|.
  Rat   356 VTGSSQVHVSRHFKVWSLRRDPLGAPAWATVGSWQDGQLD-FQPGAA-ALRV---PSPSGTQARP 415

  Fly   246 SLLVGSITYVPYTIT------NYVPAGQGDVDPIHPQWPNRSLTFD--------GAEANVMKTFC 296
            .|.|.::...|:..|      ...||||..:||    ..|.|...|        |:....::..|
  Rat   416 KLRVVTLVEHPFVFTRESDEDGQCPAGQLCLDP----GTNDSARLDALFAALVNGSVPRTLRRCC 476

  Fly   297 Q----------VHNCHLRVEAY--GADNWGGIYDNESSDGMLGDIYEQRVEMAIGCIYNWYDGIT 349
            .          ..:.....|.|  |...:|.:.|...: |::||:...|..||          :|
  Rat   477 YGYCIDLLERLAEDLAFDFELYIVGDGKYGALRDGRWT-GLVGDLLAGRAHMA----------VT 530

  Fly   350 ETSHTIARSSV---------TILG------PAPAPLPSWRTNIMPFNNRAWLVLISTLVICGTFL 399
            ..|...|||.|         |.||      ...:|:.::   :.|.:...|:.:.:.|.:...||
  Rat   531 SFSINSARSQVVDFTSPFFSTSLGIMVRTRDTASPIGAF---MWPLHWSMWVGVFAALHLTALFL 592

  Fly   400 YFMKYVS-YRL----RYSGTQVKFHHSRKLEKSMLDIFALFI--QQPSAPLSFDRFAPRFF--LA 455
            ...::.| |.|    |..||  .|.:|..|......:|...:  :.|..|..      ||.  |.
  Rat   593 TLYEWRSPYGLTPRGRNRGT--VFSYSSALNLCYAILFGRTVSSKTPKCPTG------RFLMNLW 649

  Fly   456 TILCATITLENIYSGQLKSML----TFPFYSAPVDTIEKWAQSGWKWSAPSIIWVHTVQSSDLET 516
            .|.|..:.  :.|:..|.:::    ||...|...|........|:::..   :|    :||   .
  Rat   650 AIFCLLVL--SSYTANLAAVMVGDKTFEELSGIHDPKLHHPSQGFRFGT---VW----ESS---A 702

  Fly   517 EQILARNF-EVHDYSYLSNVSFMPNYGFGIERLSSGSLSVGDYVSTEALENRIVLHDDLYFDYTR 580
            |..:..:| |:|.:....:....|:   |:..|:|....:..::..::|           .||..
  Rat   703 EAYIKASFPEMHAHMRRHSAPTTPH---GVAMLTSDPPKLNAFIMDKSL-----------LDYEV 753

  Fly   581 AV-------------SIRGW-ILMPE-------LNKHIRTCQETGLYFHWELEFIDKYMDKKKQE 624
            ::             :|.|: |.:|:       |::.|...:.:|        |||...||..:.
  Rat   754 SIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSG--------FIDLLHDKWYKM 810

  Fly   625 VLMDLANGHKVKGAPQALD--VRNIAGALFVLAFGVAFAGCALVAELLIHRMDLSK 678
            |    ..|.:|....:.|.  |.:.:|...:|..|:..|....:.|.:.:|:.|.:
  Rat   811 V----PCGKRVFAVTETLQMGVYHFSGLFVLLCLGLGSALLTSLGEHVFYRLVLPR 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir92a	NP_001097845.2	None
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	21..405	CDD:107372	63/310 (20%)
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	92/453 (20%)
		Lig_chan	576..842	CDD:278489	61/311 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	882..910
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250	951..984
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350130
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930