DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir92a and Grik2

DIOPT Version :9

Sequence 1:	NP_001097845.2	Gene:	Ir92a / 42415	FlyBaseID:	FBgn0038789	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_011241422.1	Gene:	Grik2 / 14806	MGIID:	95815	Length:	943	Species:	Mus musculus

Alignment Length:	836	Identity:	155/836 - (18%)
Similarity:	275/836 - (32%)	Gaps:	274/836 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LQPLVMHLSQLLRIIVGQYFAEFPSILIVYNNSASTTPLQLEYLSA-----LELVLREL------ 56
            |.|....||:.:..:| |:| ::.::.:||::|.....|| |.:.|     |.|.:|:|
Mouse   149 LYPDFSSLSRAILDLV-QFF-KWKTVTVVYDDSTGLIRLQ-ELIKAPSRYNLRLKIRQLPADTKD 210

  Fly    57 SKPI-----RLQWINVAFLKDLNDLEDQVMGALNSSVTEGFITILSQTHHFIHA----------- 105
            :||:     |.:..:|.|  |.:  .:...|.|..::..|.:|   :.:|:|..
Mouse   211 AKPLLKEMKRGKEFHVIF--DCS--HEMAAGILKQALAMGMMT---EYYHYIFTTLDLFALDVEP 268

  Fly   106 -RYYATRNANVRLKDKRYLFLCEDESPAELLCMDILQFYPHHLMVRPGTETAPTGPTGPHPD--- 166
             ||........|:.:...   .:..|..|...|:.||              ||     |.||
Mouse   269 YRYSGVNMTGFRILNTEN---TQVSSIIEKWSMERLQ--------------AP-----PKPDSGL 311

  Fly   167 ----------------------------------------PRRGGGASVSTKNKDDGEGGAG--- 188
                                                    |.|.|...:|...:...||..|
Mouse   312 LDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRIT 376

  Fly   189 -NKTTSPYRDINFELWTQKFVG--AVGNLDALLLDAFLPNETFANRVELYPNKLLN----LQRRS 246
             |||.....|.:.::.:.|..|  .:|..|        |:... |..|....|..|    |..||
Mouse   377 FNKTNGLRTDFDLDVISLKEEGLEKIGTWD--------PSSGL-NMTESQKGKPANITDSLSNRS 432

  Fly   247 LLVGSITYVPYTITNYVPAGQGDVDPIHPQWPNRSLTFDGAEANVMKTFCQVHNCHLRVEAYGAD 311
            |:|.:|...||.:..     :.|    .|.:.|.  .|:|...::::....:......:......
Mouse   433 LIVTTILEEPYVLFK-----KSD----KPLYGND--RFEGYCIDLLRELSTILGFTYEIRLVEDG 486

  Fly   312 NWGGIYD-NESSDGMLGDIYEQRVEMAIGCIYNWY--DGITETSHTIARSSVTILGPAP-APLPS 372
            .:|...| |...:||:.::.:.:.::|:..:...|  :.:.:.|.......::||...| ...|.
Mouse   487 KYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPG 551

  Fly   373 WRTNIMPFNNRAWL-VLISTL-VICGTFLYFMKYVSYRLRYSGTQVKFHHSRK------LEKSM- 428
            ..:.:.|.:...|: :|::.| |.|..|:...:......:|.... .:|||::      ||..|
Mouse   552 VFSFLNPLSPDIWMYILLAYLGVSCVLFVIARQSKFSWFKYPNCS-HYHHSQRCLCTQHLESYME 615

  Fly   429 LDIFALF-------------------------------IQQPSAPLSFDRFAPR-------FFLA 455
            |.:|:.:                               :.|..:.|.....:.|       ||
Mouse   616 LCLFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFF-- 678

  Fly   456 TILCATITLENIYSGQLKSMLTFPFYSAPVDTIEKWAQ------------------SGWKWSAPS 502
                 |:.:.:.|:..|.:.||.....:|:|:.:..|:                  ...|.|...
Mouse   679 -----TLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYD 738

  Fly   503 IIWVH--------TVQSSDLETEQILARNFEVHDYSYL---SNVSFMPNYGFGIERLSSGSLSVG 556
            .:|..        .|:|::...:::|     ..||::|   :.:.|:......:.::.....|.|
Mouse   739 KMWAFMSSRRQSVLVKSNEEGIQRVL-----TSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKG 798

  Fly   557 DYVSTEALENRIVLHDDLYFDYTRAVSIRGWILMPELNKHIRTCQETGLYFHWELEFIDKYMDKK 621
            ..|.|           .:...|...::|.           |...||.|          ..:|.|:
Mouse   799 YGVGT-----------PMGSPYRDKITIA-----------ILQLQEEG----------KLHMMKE 831

  Fly   622 KQEVLMDLANGHKVKGAPQ-------ALDVRNIAGALFVLAFGVAFAGCALVAELL 670
            |         ..:..|.|:       ||.|:||.|...|||.|:..:....|.|.|
Mouse   832 K---------WWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFL 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir92a	NP_001097845.2	None
Grik2	XP_011241422.1	PBP1_iGluR_Kainate	37..414	CDD:380605	60/305 (20%)
Grik2	XP_011241422.1	Periplasmic_Binding_Protein_Type_2	430..835	CDD:389745	76/469 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846629
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840