DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir92a and Grid2

DIOPT Version :9

Sequence 1:	NP_001097845.2	Gene:	Ir92a / 42415	FlyBaseID:	FBgn0038789	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_032193.1	Gene:	Grid2 / 14804	MGIID:	95813	Length:	1007	Species:	Mus musculus

Alignment Length:	772	Identity:	138/772 - (17%)
Similarity:	293/772 - (37%)	Gaps:	180/772 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MHLSQLLRIIVGQYFAEFPSILIVYNNSASTTPLQLEYLS---------ALELVLRELSKPI--- 60
            ::|::::..:|.:|  .:...:|.|::......:| |:|.         ||:.|...::|.|
Mouse   150 VYLNEVILRVVTEY--AWQKFIIFYDSEYDIRGIQ-EFLDKVSQQGMDVALQKVENNINKMITTL 211

  Fly    61 ----RLQWIN------------------------------VAF-------LKDLNDLEDQVMGAL 84
                |::.:|                              |||       .:::||::.|.:  :
Mouse   212 FDTMRIEELNRYRDTLRRAILVMNPATAKSFISEVVETNLVAFDCHWIIINEEINDVDVQEL--V 274

  Fly    85 NSSVTEGFITILSQTH---HFIHARYYATRNANVRLKDKRYLFLCEDESP-AELLCMDILQFYPH 145
            ..|:  |.:||:.||.   ..|..|.:   ..|.|:...    ||:.:.| |:.:.:..|..|..
Mouse   275 RRSI--GRLTIIRQTFPVPQNISQRCF---RGNHRISSS----LCDPKDPFAQNMEISNLYIYDT 330

  Fly   146 HLMV----------RPGTETAPTGPTGPHPDPRRGGGASVSTKNK----------DDGEGGAGNK 190
            .|::          |.....|.......:..|.:||.:.:.|..|          :.||.| ||.
Mouse   331 VLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVNGLTGDLEFGENG-GNP 394

  Fly   191 TTSPYRDINFELWTQKFVGAVG-------------NLDALLLDAFLPNETFANRVELYPNKLLNL 242
                  :::||:....:...:|             .|:..|.|..|.|               |:
Mouse   395 ------NVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLEN---------------NM 438

  Fly   243 QRRSLLVGSITYVPYTITNYVPAGQGDVDPIHPQWPNRSLTFDGAEANVMKTFCQVHNCHLRVEA 307
            :...|.|.::...|:.:.:....|:          |.:   :.|...:|:.........:..:..
Mouse   439 RGVVLRVVTVLEEPFVMVSENVLGK----------PKK---YQGFSIDVLDALSNYLGFNYEIYV 490

  Fly   308 YGADNWGGIYDNESSDGMLGDIYEQRVEMAIGCIYNWYD--GITETSHTIARSSVTILGPAPAPL 370
            .....:|...::.:.:|::|::..:|.::.|..:....|  .:.:.:......||.:|.......
Mouse   491 APDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRRAEKT 555

  Fly   371 PSWRTNIMPFNNRAWLVLISTLVICGTFLYFMKYVSYRLRYSGTQVKFHHSRKLEKSMLDIFALF 435
            ......:.||:...|..:..|:::.|..:|.:.:::......|:..    |..|..||..::..|
Mouse   556 VDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSMT----STTLYNSMWFVYGSF 616

  Fly   436 IQQPSAPLSFDRFAPRFFL-ATILCATITLENIYSGQLKSMLTFPFYSAPVDTIE---KWAQSGW 496
            :|| ...:.:...|.|..: |..|.|.|.:.: |:..|.:.||.....:.:.:::   |.....:
Mouse   617 VQQ-GGEVPYTTLATRMMMGAWWLFALIVISS-YTANLAAFLTITRIESSIQSLQDLSKQTDIPY 679

  Fly   497 KWSAPSIIWVHTVQS--SDLETEQILARNFEVHDYSYLSNVSFMPNYGFGIERLSSGSLSVGDYV 559
            .....|.::.|....  :..|.:.:.::.:.:.:.|..|..:.:.:.. ||:::..|:.:   :|
Mouse   680 GTVLDSAVYQHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVLESQA-GIQKVKYGNYA---FV 740

  Fly   560 STEALENRIVLHD-DLYFDYT--RAVSIRGWILMPE--------LNKHIRTCQETGLYFHWELEF 613
            ...|:...:.::| |..| ||  ..|:.||:.:..:        .::.|...|::|     :::.
Mouse   741 WDAAVLEYVAINDPDCSF-YTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSG-----DMDI 799

  Fly   614 I-DKYMDKKKQEVLMDLANGHKVKGAPQALDVRNIAGALFVLAFGVAFAGCALVAEL 669
            : .|:..|..|   .||.:....|....|||::::||...:||.|:..:  .|:|.|
Mouse   800 LKHKWWPKNGQ---CDLYSSVDAKQKGGALDIKSLAGVFCILAAGIVLS--CLIAVL 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir92a	NP_001097845.2	None
Grid2	NP_032193.1	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		38/208 (18%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:385651	54/299 (18%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	63/394 (16%)
		Interaction with AP4M1. /evidence=ECO:0000250\|UniProtKB:Q63226	921..991
		PDZ-binding	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846505
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840