DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir92a and Gria2

DIOPT Version :9

Sequence 1:	NP_001097845.2	Gene:	Ir92a / 42415	FlyBaseID:	FBgn0038789	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001344853.2	Gene:	Gria2 / 14800	MGIID:	95809	Length:	901	Species:	Mus musculus

Alignment Length:	808	Identity:	153/808 - (18%)
Similarity:	276/808 - (34%)	Gaps:	239/808 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PLVMHL-----SQLLRIIVGQYFAEFPSILIVYNNSASTTPLQLEYLSALELVLRELSKPIRLQW 64
            |.|:.:     ..||.:|  :|: ::.....:|::....:.||....||.|       |..::..
Mouse   123 PFVIQMRPDLKGALLSLI--EYY-QWDKFAYLYDSDRGLSTLQAVLDSAAE-------KKWQVTA 177

  Fly    65 INVAFLKDLNDLEDQVMGAL--------------------NSSVTEGFITILSQT--HHFIHARY 107
            |||..:.  ||.:|:...:|                    .:.:.:..|||....  :|:|.|..
Mouse   178 INVGNIN--NDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANL 240

  Fly   108 YAT---------RNANV---RLKD----------KRYLFLCEDESP---------AELLCMDILQ 141
            ..|         ..|||   ::.|          :|:..|.|.|.|         ...|..|.:|
Mouse   241 GFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQ 305

  Fly   142 FYPHHL--MVRPGTETAPTGPTG---PHPDPRRGGGASVSTKNKD-DGEGGAGN-KTTSPYRDIN 199
            ......  :.:...|.:..|..|   .:|....|.|..:....|. ..||.:|| |.....:.||
Mouse   306 VMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRIN 370

  Fly   200 F-----ELWTQ--KFVGAVGNLDALLLD-AFLPNETFANRVELYPNKLLNLQRRSLLVGSITYVP 256
            :     ||.|.  :.:|....:|.:::. ..||:          .|....|:.::::|.:|...|
Mouse   371 YTINIMELKTNGPRKIGYWSEVDKMVVTLTELPS----------GNDTSGLENKTVVVTTILESP 425

  Fly   257 YTITNYVPAGQGDVDPIHPQWPNRSLTFDGAE----------ANVMKTFCQVHNCHLRVE----- 306
            |.:..                .|..: .:|.|          |.:.|      :|..:.:
Mouse   426 YVMMK----------------KNHEM-LEGNERYEGYCVDLAAEIAK------HCGFKYKLTIVG 467

  Fly   307 --AYGADNWGGIYDNESSDGMLGDIYEQRVEMAIGCIYNWYDGITETSHTIARSSVTILGPAPAP 369
              .|||.:    .|.:..:||:|::...:.::||..:          :.|:.|..|....   .|
Mouse   468 DGKYGARD----ADTKIWNGMVGELVYGKADIAIAPL----------TITLVREEVIDFS---KP 515

  Fly   370 LPSWRTNIM----------------PFNNRAWLVLISTLVICGTFLYFMKYVSYRLRYSGTQVKF 418
            ..|...:||                |.....|:.::...:.....|:.:...|   .|.....:|
Mouse   516 FMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFS---PYEWHTEEF 577

  Fly   419 HHSRKLEKS-MLDIFALF---------IQQPSAPLSFDRFAPRFFLATILCA-----TITLENIY 468
            ...|:.:.| ..:.|.:|         ..|....:|     ||.....|:..     |:.:.:.|
Mouse   578 EDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDIS-----PRSLSGRIVGGVWWFFTLIIISSY 637

  Fly   469 SGQLKSMLTFPFYSAPVDTIEKWAQSGWKWSAPSIIWVHTVQSSDLETEQILARN-FEVHD--YS 530
            :..|.:.||.....:|:::.|       ..|..:.|...|:.|.  .|::...|: ..|.|  ::
Mouse   638 TANLAAFLTVERMVSPIESAE-------DLSKQTEIAYGTLDSG--STKEFFRRSKIAVFDKMWT 693

  Fly   531 YLSNVS---FMPNYGFGIERLSSGSLSVGDYV----ST--EALENR-----IVLHDDLYFDYTRA 581
            |:.:..   |:.....|:.|:..   |.|.|.    ||  |.:|.|     :.:..:|.......
Mouse   694 YMRSAEPSVFVRTTAEGVARVRK---SKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGI 755

  Fly   582 VSIRGWILMPELNKHIRTCQETGLYFHWELEFIDKYMDKKKQEVLMDLAN-GHKVKGAPQ---AL 642
            .:.:|..|...:|..:....|.|:            :||.|.:...|... |.|..|:.:   ||
Mouse   756 ATPKGSSLRTPVNLAVLKLSEQGV------------LDKLKNKWWYDKGECGAKDSGSKEKTSAL 808

  Fly   643 DVRNIAGALFVLAFGVAFAGCALVAELL 670
            .:.|:||..::|..|:   |.|::..|:
Mouse   809 SLSNVAGVFYILVGGL---GLAMLVALI 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir92a	NP_001097845.2	None
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	58/286 (20%)
Gria2	NP_001344853.2	PBP2_iGluR_AMPA	413..794	CDD:270433	78/452 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846636
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840