Protein Alignment Ir92a and Gria1

DIOPT Version :10

• Sequence 1: NP_001097845.2
• Gene: Ir92a / 42415
• FlyBaseID: FBgn0038789
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_032191.2
• Gene: Gria1 / 14799
• MGIID: 95808
• Length: 907
• Species: Mus musculus
• Alignment Length: 610
• Identity: 110/610 - (18%)
• Similarity: 194/610 - (31%)
• Gaps: 225/610 - (36%)

  Fly   185 GGAGNKTTSPY------RDINFELWTQKFVGAVGNL--------------------DALLL---- 219
            |.||:...:|.      .||...|...:|.|..||:                    |.:..
Mouse   318 GNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYW 382

  Fly   220 ---DAFLPNETFANRVELYPNKLLNLQRRSLLVGSITYVPYTITNYVPAGQGDVDPIHPQWPNRS 281
               |.|:|..|.|..    .....::|.|:.:|.:|...||.:..                 ..:
Mouse   383 NEDDKFVPAATDAQA----GGDNSSVQNRTYIVTTILEDPYVMLK-----------------KNA 426

  Fly   282 LTFDGAE----------ANVMKTFCQVHNCHL----RVE-----AYGADNWGGIYDNESSDGMLG 327
            ..|:|.:          |.:.|        |:    |:|     .|||.:    .|.::.:||:|
Mouse   427 NQFEGNDRYEGYCVELAAEIAK--------HVGYSYRLEIVSDGKYGARD----PDTKAWNGMVG 479

  Fly   328 DIYEQRVEMAIGCIYNWYDGITETSHTIARSSVTILGPAPAPLPSWRTNIM-------------- 378
            ::...|.::|:..:          :.|:.|..|....   .|..|...:||
Mouse   480 ELVYGRADVAVAPL----------TITLVREEVIDFS---KPFMSLGISIMIKKPQKSKPGVFSF 531

  Fly   379 --PFNNRAWLVLISTLVICGTFLYFMKYVSYRLRYSGTQVKFHHSRKLEK--------------- 426
              |.....|:.::...:.....|:.:.      |:|..:   .||.:.|:
Mouse   532 LDPLAYEIWMCIVFAYIGVSVVLFLVS------RFSPYE---WHSEEFEEGRDQTTSDQSNEFGI 587

  Fly   427 --SMLDIFALFIQQPSAPLSFDRFAPRFFLATILCA-----TITLENIYSGQLKSMLTFPFYSAP 484
              |:......|:||..      ..:||.....|:..     |:.:.:.|:..|.:.||.....:|
Mouse   588 FNSLWFSLGAFMQQGC------DISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSP 646

  Fly   485 VDTIEKWA----------QSG-----------------WKW--SAPSIIWVHTVQSSDLETEQIL 520
            :::.|..|          ::|                 |.:  ||...::|.|.:...:...:..
Mouse   647 IESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSK 711

  Fly   521 ARNFEVHDYSYLSNVSFMPNYGFGIE-RLSSGSLSVGDYVSTEALENRIVLHDDLYFDYTRAVSI 584
            .:      |:||.. |.|..|   || |....::.||..:.::.              |..|..
Mouse   712 GK------YAYLLE-STMNEY---IEQRKPCDTMKVGGNLDSKG--------------YGIATP- 751

  Fly   585 RGWILMPELNKHIRTCQETGLYFHWELEFIDKYMDKKKQEVLMDL----ANGHKVKGAPQALDVR 645
            :|..|...:|..:....|.||            :||.|.:...|.    :.|...|....||.:.
Mouse   752 KGSALRNPVNLAVLKLNEQGL------------LDKLKNKWWYDKGECGSGGGDSKDKTSALSLS 804

  Fly   646 NIAGALFVLAFGVAFAGCALVAELL 670
            |:||..::|..|:   |.|::..|:
Mouse   805 NVAGVFYILIGGL---GLAMLVALI 826

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir92a	NP_001097845.2	None
Gria1	NP_032191.2	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	15/73 (21%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	80/474 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881
		PDZ-binding	904..907