Protein Alignment Ir92a and GRIN3B

DIOPT Version :10

• Sequence 1: NP_001097845.2
• Gene: Ir92a / 42415
• FlyBaseID: FBgn0038789
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_619635.1
• Gene: GRIN3B / 116444
• HGNCID: 16768
• Length: 1043
• Species: Homo sapiens
• Alignment Length: 656
• Identity: 128/656 - (19%)
• Similarity: 219/656 - (33%)
• Gaps: 210/656 - (32%)

  Fly   116 RLKDKRYLFLCEDESPAELLCMDILQFYPH---HLMVRPGTETAPTGPTGP-------------- 163
            :::.||.|.      ||.:.|.|:....|.   ..:.|....|:..|.|||
Human   309 QVQPKRALL------PAPVNCGDLQPAGPESPGRFLARFLANTSFQGRTGPVWVTGSSQVHMSRH 367

  Fly   164 ------HPDPRRGGGASVSTKNKDDGE-----GGAGNKTTSPYRDINFELWTQKFVGAVGNLDAL 217
                  ..|| ||..|..:..:..||:     |||..:...|.   ..::|.:  :..|..|:..
Human   368 FKVWSLRRDP-RGAPAWATVGSWRDGQLDLEPGGASARPPPPQ---GAQVWPK--LRVVTLLEHP 426

  Fly   218 LLDAFLPNETFANRVELYPNKLLNLQRRSLLVGSITYVPYTITNYVPAGQGDVDPIHPQWPNRSL 282
            .:.|..|:|                                 ....||||..:||    ..|.|.
Human   427 FVFARDPDE---------------------------------DGQCPAGQLCLDP----GTNDSA 454

  Fly   283 TFD--------GAEANVMKTFCQ----------VHNCHLRVEAY--GADNWGGIYDNESSDGMLG 327
            |.|        |:....::..|.          ..:.....|.|  |...:|.:.|...: |::|
Human   455 TLDALFAALANGSAPRALRKCCYGYCIDLLERLAEDTPFDFELYLVGDGKYGALRDGRWT-GLVG 518

  Fly   328 DIYEQRVEMAIGCIYNWYDGITETSHTIARSSV---------TILG------PAPAPLPSWRTNI 377
            |:...|..||          :|..|...|||.|         |.||      ...:|:.::   :
Human   519 DLLAGRAHMA----------VTSFSINSARSQVVDFTSPFFSTSLGIMVRARDTASPIGAF---M 570

  Fly   378 MPFNNRAWLVLISTLVICGTFLYFMKYVS-YRL--RYSGTQVKFHHSRKLEKSMLDIFALFIQQ- 438
            .|.:...||.:.:.|.:...||...::.| |.|  |.......|.:|..|......:|...:..
Human   571 WPLHWSTWLGVFAALHLTALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAILFRRTVSSK 635

  Fly   439 ----PSAPLSFDRFAPRFFLATILCATITLENIYSGQLKSML----TFPFYSAPVDTIEKWAQSG 495
                |:..|..:.:|       |.|..:.  :.|:..|.:::    ||...|...|........|
Human   636 TPKCPTGRLLMNLWA-------IFCLLVL--SSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQG 691

  Fly   496 WKWSAPSIIWVHTVQSSDLETEQILARNF-EVHDYSYLSNVSFMPNYGFGIERLSSGSLSVGDYV 559
            :::..   :|    :||   .|..:.::| ::|.:....:....|.   |:..|:|....:..::
Human   692 FRFGT---VW----ESS---AEAYIKKSFPDMHAHMRRHSAPTTPR---GVAMLTSDPPKLNAFI 743

  Fly   560 STEALENRIVLHDDLYFDYTRAV-------------SIRGW-ILMPE-------LNKHIRTCQET 603
            ..::|           .||..::             :|.|: |.:|:       |::.|...:.:
Human   744 MDKSL-----------LDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSS 797

  Fly   604 GLYFHWELEFIDKYMDKKKQEVLMDLANGHKVKGAPQAL--DVRNIAGALFVLAFGVAFAGCALV 666
            |        |||...||..:.|    ..|.:|....:.|  .:.:.||...:|..|:   |.||:
Human   798 G--------FIDLLHDKWYKMV----PCGKRVFAVTETLQMSIYHFAGLFVLLCLGL---GSALL 847

  Fly   667 AELLIH 672
            :.|..|
Human   848 SSLGEH 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir92a	NP_001097845.2	None
GRIN3B	NP_619635.1	PBP1_iGluR_NMDA_NR3	29..401	CDD:380600	22/98 (22%)
		PBP2_iGluR_NMDA_Nr3	415..808	CDD:270438	89/486 (18%)
		Lig_chan	574..841	CDD:459656	57/311 (18%)