DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir92a and LOC110438919

DIOPT Version :9

Sequence 1:	NP_001097845.2	Gene:	Ir92a / 42415	FlyBaseID:	FBgn0038789	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_021328141.1	Gene:	LOC110438919 / 110438919	-ID:	-	Length:	1417	Species:	Danio rerio

Alignment Length:	698	Identity:	135/698 - (19%)
Similarity:	242/698 - (34%)	Gaps:	155/698 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 DLEDQVMGALNSSVTEG---FITILSQTHHFIHARYYATRNAN--------VRLKDKRYLFLC-- 126
            :||:.::  |:.||.:|   ...:|.:....:...|.....||        |.|....|.::.
Zfish    57 ELEEVLL--LDMSVDDGDAKIQNLLKKLQSPVILLYSTKEEANIIFQVAHSVGLTGYGYTWIVPS 119

  Fly   127 -----EDESPAE----LLCMDILQF-YPHHLMVRPGTETAPTGPT------GPH----------P 165
                 .|..|||    ::.:...:: |.....||.|.....|..:      |||          |
Zfish   120 LVAGDADHIPAEFPTGMISVSYDEWDYGLEARVRDGVAVIATATSTMMMDRGPHTLLKSECHGAP 184

  Fly   166 DPRRGGGASVSTKNKDDGEGGAGNKTTSPYRDINFELWTQKFVGAVGNLDALLLDAFLPNETFAN 230
            |             |.....|..|:......::.||.....|......:...|:...|..|...:
Zfish   185 D-------------KKSPMTGNNNEVLRYLMNVTFEGRNLSFSEDGYQMHPKLVIILLDKERQWD 236

  Fly   231 RVELYPNKLLNLQ-----RRSLLVG------------SITYVPYTITNYVPAGQGDVDPI----- 273
            ||..:.|..|:::     |..|..|            ::...|:.|..       ||||:
Zfish   237 RVGKWENGSLSMKYHVWPRFELYSGPEAREDDHLSIVTLEEAPFVIVE-------DVDPLSGTCM 294

  Fly   274 ------HPQWPNRSLTFDGAE--ANVMKTFC------QVHNCHLRVEAYGADNW-GGIYDNESSD 323
                  ..|....:.|.|.|.  ....|.||      ...|.....:.|...|. .|...|.:.:
Zfish   295 RNTVPCRKQLKALNQTQDSAVYIKRCCKGFCIDILKKIAKNVKFTYDLYLVTNGKHGKKINGTWN 359

  Fly   324 GMLGDIYEQRVEMAIGCIYNWYDGITETSHTIARSSVTILGPAPAPLPSWRTN--------IMPF 380
            ||:|::..:...||:|.:     .|.|....:...||..:....:.:.| |:|        :.||
Zfish   360 GMVGEVVLKNAHMAVGSL-----TINEERSEVIDFSVPFIETGISVMVS-RSNGTVSPSAFLEPF 418

  Fly   381 NNRAWLVL-ISTLVICGTFLYFMKY---VSYRLRYSGTQVKFHHSRKLEKSMLDIFALF------ 435
            :...|::: :..|::....::..:|   |.|....:..:.....|..:.|::..::.|.
Zfish   419 SADVWIMMFVMLLLVSAIAVFIFEYFSPVGYNRCLADGREAGGPSFTIGKAIWLLWGLVFNNSVP 483

  Fly   436 IQQPSAPLSFDRFAPRFFLATILCATITLENIYSGQLKSMLTFPFYSAPVDTI----EKWAQSGW 496
            :|.|....|....:...|.|.|..|:.|         .::..|......||.:    :|..|:..
Zfish   484 VQNPRGTTSKIMVSVWAFFAVIFLASYT---------ANLAAFMIQEEYVDQVSGLSDKKFQNPN 539

  Fly   497 KWSAPSIIWVHTVQSSDLETEQILARNF-EVHDYSYLSNVSF-MPNYGFGIERLSSGSLSVGDYV 559
            .:|.|  ....||.:.  .||:.:..|: ::|.|.    |.| ..|....:|.|.:|.|..  ::
Zfish   540 DFSPP--FRFGTVPNG--STERNIRNNYRDMHSYM----VKFHQRNVVEALESLKTGKLDA--FI 594

  Fly   560 STEALENRIVLHDDLYFDYTRAVSIRGWILMPELNKHIRTCQETGLYFHWELEFIDKYMDKKKQE 624
            ...|:.|.:...|    :..:.|:|....:.......|...:::|.....:|..:..:.|.:.:|
Zfish   595 YDAAVLNYMAGRD----EGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEE 655

  Fly   625 V----LMDLANGHKVKGAPQALDVRNIAGALFVLAFGVAFAGCALVAE 668
            :    |..:.:..|.:.....|||.|:||..::|...:|.:....:||
Zfish   656 LEALWLTGICHHEKNEVMSSQLDVDNMAGVFYMLGAAMALSLITFIAE 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir92a	NP_001097845.2	None
LOC110438919	XP_021328141.1	PBP1_iGluR_NMDA_NR2	<1..255	CDD:107373	40/212 (19%)
		PBP2_iGluR_NMDA_Nr2	267..667	CDD:270436	81/435 (19%)
		DUF4013	<389..478	CDD:315788	15/89 (17%)
		NMDAR2_C	704..1417	CDD:313729	135/698 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591423
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840