DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir92a and grin3bb

DIOPT Version :9

Sequence 1:	NP_001097845.2	Gene:	Ir92a / 42415	FlyBaseID:	FBgn0038789	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_017213803.2	Gene:	grin3bb / 100333101	ZFINID:	ZDB-GENE-131122-77	Length:	1114	Species:	Danio rerio

Alignment Length:	512	Identity:	106/512 - (20%)
Similarity:	181/512 - (35%)	Gaps:	147/512 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 LLVGSITYVPYTITNYV------PAGQGDVDPIHPQWPNRSLTFD-----GAEANVMKTF----- 295
            |.|.::...|:..|..|      ||||..:|    ...|.|.|.|     .|:.|  |:|
Zfish   458 LRVVTLVEHPFVFTREVDEDGNCPAGQYCLD----AGTNSSETLDHLYAERAQGN--KSFLPPDY 516

  Fly   296 --CQVHNC-----------HLRVEAY--GADNWGGIYDNESSDGMLGDIYEQRVEMAIGCIYNWY 345
              |....|           :...:.|  |...:|.:...:.: |::||:.....:||
Zfish   517 SKCCYGYCIDLLEKLSEDMNFEFDLYIVGDGKYGAVKGGQWT-GLVGDLLSGVADMA-------- 572

  Fly   346 DGITETSHTIARSSV---------TILG------PAPAPLPSWRTNIMPFNNRAWLVLISTLVIC 395
              :|..|...|||.|         |.||      ...||:.::   :.|.:...|:.:...|.|.
Zfish   573 --VTSFSINSARSKVIDFTSPFFSTSLGILVRSKDTAAPIGAF---MWPLHWSMWMGIFVALHIT 632

  Fly   396 GTFLYFMKYVS-YRLRYSG-TQVK-FHHSRKLEKSMLDIFALFIQQPSAPLSFDRFAPRFFLATI 457
            ..||...::.| :.:...| .:|| |.:|..|......:|...:...:......||...  |..|
Zfish   633 ALFLTLYEWKSPFGMTPHGRNRVKVFSYSSALNLCYAILFGRTVSSKTPKCWTGRFLMN--LWAI 695

  Fly   458 LCATITLENIYSGQLKSML----TFPFYSAPVDTIEKWAQSGWKWSAPSIIWVHTVQSSDLETEQ 518
            .|..:.  :.|:..|.:::    ||...|...|........|:::.        ||:.|  ..|.
Zfish   696 FCLLVL--SSYTANLAAVMVGEKTFEEVSGIHDAKLHHPSQGFRFG--------TVRES--SAED 748

  Fly   519 ILARNF-EVHDYSYLSNVSFMPNYGFGIERLSSGSLSVGDYVSTEALENRIVLHDDLYFDYTRAV 582
            .:.::| |:|:|....|....|:   |:..|.:....:..::..:||           .||..::
Zfish   749 YMKKSFPEMHEYMRKFNEPTTPD---GVATLKTDPPQLDAFIMDKAL-----------LDYEVSI 799

  Fly   583 -------------SIRGW-ILMPE---LNKHIRTCQETGLYFHWELEFIDKYMDKKKQEVLMDLA 630
                         :|.|: |.:|:   |..:|.             ||:.:|    |.:..||:.
Zfish   800 DADCKLLTVGKPFAIEGYGIGLPQNSPLTSNIS-------------EFVSRY----KSDGYMDML 847

  Fly   631 N---------GHKVKGAPQALD--VRNIAGALFVLAFGVAFAGCALVAELLIHRMDL 676
            :         |.:|....:.|.  :|:.:|...:|..||..|...|..|...:|:.|
Zfish   848 HDKWYKVVPCGKRVFAVTETLQMGIRHFSGLFVLLCVGVTGALLTLAGEHAFYRLVL 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir92a	NP_001097845.2	None
grin3bb	XP_017213803.2	PBP1_iGluR_NMDA_NR3	29..428	CDD:107372
grin3bb	XP_017213803.2	PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	93/458 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591705
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840