DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir92a and LOC100149482

DIOPT Version :9

Sequence 1:	NP_001097845.2	Gene:	Ir92a / 42415	FlyBaseID:	FBgn0038789	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_009290417.1	Gene:	LOC100149482 / 100149482	-ID:	-	Length:	1959	Species:	Danio rerio

Alignment Length:	791	Identity:	161/791 - (20%)
Similarity:	278/791 - (35%)	Gaps:	216/791 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GQYFAEFPSILIVYNNSASTTPLQLEYLSALELVLRELSKPIRLQWINVA-----------FLKD 72
            |..|.:|          :|:|.||||.:..   ||.|      ..|...:           ||..
Zfish   169 GSIFLQF----------SSSTALQLEVIFE---VLEE------YDWTAFSVVSTRHHGYQDFLSV 214

  Fly    73 LNDLED-QVMGALNSSVTEGFITILSQTHHFIHARYYATRNANVRLKDKRYLFLCEDESPAELLC 136
            :..|.| ..:|....|:.  .:.:..........|......|.|||     |:..::|:....|.
Zfish   215 VEGLTDGSFIGWEKKSIV--MLNLTDDPGGVRTQRLLKENEAQVRL-----LYCSQEEAEQVFLA 272

  Fly   137 MDIL-QFYPHHLMVRPG---TETAPTG---------PTGPHPDPRR--GGGASVSTK-----NKD 181
            .... |....|:....|   :|...||         |.|...:|||  ..|.|:.|.     .||
Zfish   273 AWAAGQAGASHIWFAVGPALSELGLTGLPKRLFAVRPQGWRDEPRRRIARGVSILTHGAVALRKD 337

  Fly   182 DGEGGAGNKTTSPYRDINFELWTQKFVGAVGNLDALLL---DAFLPNETF-AN------------ 230
            .|..|..:..|:...|.|   .||:..|.:.....:.|   |....||.: ||
Zfish   338 YGATGGPHFVTNCQTDGN---RTQRIRGRMRYFSNITLGGRDYSFSNEGYLANPFLDVISYTPGS 399

  Fly   231 ---RVELYPNKLLNLQ----------------RRSLLVGSITYVPYTITNYVPAGQGDV--DPIH 274
               .|..:.|.:|.|:                .:.|.|.::...|:.|.....|..|..  |.:.
Zfish   400 GWEDVGWWENGVLRLRYPAWSRYGPFLQPPDDAQHLRVVTLEERPFVIVELADAASGTCIRDSVP 464

  Fly   275 PQWP-NRSLTFDGAE----------ANVMKTFCQV----HNCHLRVEAYGADNWGGIYDNESSDG 324
            .:.| |.|...:|..          .:::|...::    ::.:|...........|::     :|
Zfish   465 CRRPLNASALQEGVAPVKQCCKGFCIDILKRLARIVGFTYDLYLVTNGKHGKKIDGVW-----NG 524

  Fly   325 MLGDIYEQRVEMAIGC---------IYNWYDGITET--SHTIARSSVTILGPAPAPLPSWRTNIM 378
            |:|::..:|.:||||.         :.::.....||  |..::||:.|:   :|:..      :.
Zfish   525 MVGEVVYKRADMAIGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTV---SPSAF------LE 580

  Fly   379 PFNNRAWL---VLISTLVICGTFLY-FMKYVSY-RLRYSGTQV---KFHHSRKLEKSMLDIFALF 435
            |::...|:   |:..|:|....|:: |...|.| |...||.:.   ||    .:.||:..::||.
Zfish   581 PYSPAVWVMMFVMCLTVVAVTVFIFEFFSPVGYNRSLQSGKKAGGSKF----TIGKSIWLLWALV 641

  Fly   436 ------IQQPSAPLSFDRFAPRFFLATILCATITLENIYSGQLKSMLTFPFYSAPVDTIEKWAQS 494
                  ::.|....|........|.|.|..|:.|         .::..|......:||:.  ..|
Zfish   642 FNNSVPVENPKGTTSKIMVLVWAFFAVIFLASYT---------ANLAAFMIQEEYIDTVS--GLS 695

  Fly   495 GWKWSAPSIIWVHTVQSSDLE--------TEQILARNF-EVHDYSYLSNVSFMPNYGFGIERLSS 550
            ..|:..|      |.|...|:        ||:.:..|: ::|.|....|...:.:   .|..|.:
Zfish   696 DKKFQHP------TEQYPPLKFGTVPNGSTEKNIRSNYPDMHQYMVKYNQKSVED---AISHLKT 751

  Fly   551 GSLSVGDYVSTEALENRIVLHDD----LYFDYTRAVSIRGWILMPELNKHIRTCQETGLYFHWE- 610
            |.|..  ::...|:.|.:...|:    :.....:..:..|:.:  .|.|:.|          |:
Zfish   752 GKLDA--FIYDAAVLNYMARKDEGCKVMTIGSGKVFATTGYGI--ALIKNSR----------WKR 802

  Fly   611 ------LEFI-DKYMDKKKQEVLMDLANGHKVKGAPQALDVRNIAGALFVL--AFGVA---FAGC 663
                  |:.: |..::..::..|..:.:..|::.....||:.|:||..::|  |.|::   ||..
Zfish   803 PLDLALLQLVGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWE 867

  Fly   664 ALVAELLIHRM 674
            .||...|.|.|
Zfish   868 HLVYWRLRHCM 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir92a	NP_001097845.2	None
LOC100149482	XP_009290417.1	PBP1_iGluR_NMDA_NR2	44..421	CDD:107373	61/280 (22%)
		PBP2_iGluR_NMDA_Nr2	433..831	CDD:270436	84/449 (19%)
		HisJ	<487..>570	CDD:223904	15/87 (17%)
		Lig_chan	585..857	CDD:278489	61/309 (20%)
		NMDAR2_C	868..>900	CDD:287527	5/11 (45%)
		FAM76	<1763..>1856	CDD:292665
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591664
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930