DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir92a and grin2ca

DIOPT Version :9

Sequence 1:	NP_001097845.2	Gene:	Ir92a / 42415	FlyBaseID:	FBgn0038789	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001352716.1	Gene:	grin2ca / 100003342	ZFINID:	ZDB-GENE-070822-3	Length:	1400	Species:	Danio rerio

Alignment Length:	529	Identity:	105/529 - (19%)
Similarity:	190/529 - (35%)	Gaps:	126/529 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 VGNLDALLLDAFLP----NETFANRVELYPNKLLNLQRRSLLVGSITYVPYTITNYVPAGQG--- 268
            |||.::.:|....|    ..||...|.         ..|.|.|.::...|:.|...|....|
Zfish   381 VGNYESGILQMRYPVWPRYGTFLEPVS---------DNRHLTVATLEERPFVIVEAVDPVTGTCL 436

  Fly   269 -DVDPIHPQWPNRSLTFDGAEANVMKTFCQ----------VHNCHLRVEAYGADNW------GGI 316
             :..|...| .|::.|..|......|..|:          ..|.....:.|...|.      .||
Zfish   437 SNTVPCRRQ-SNKTETIVGHTEPYTKLCCKGFCIDILKKLSRNIKFSYDLYLVTNGKHGKLVRGI 500

  Fly   317 YDNESSDGMLGDIYEQRVEMAIGC---------IYNWYDGITET--SHTIARSSVTILGPAPAPL 370
            :     :||:|:::.:|.:||||.         |.::.....||  |..:|||:.|:   :|:..
Zfish   501 W-----NGMIGEVFYKRADMAIGSLTINEERSEIIDFSVPFVETGISVMVARSNGTV---SPSAF 557

  Fly   371 PSWRTNIMPFNNRAWLVL-ISTLVICGTFLYFMKYVSYRLRYSGTQVKFHHSRK--------LEK 426
                  :.|::...|::: :..|.:....::..:|.| .:.|:.:.|    |.|        :.|
Zfish   558 ------LEPYSPAVWVMMFVMCLTVVAVTVFVFEYCS-PVGYNRSLV----SAKDPGGPTFTIGK 611

  Fly   427 SMLDIFALF------IQQPSAPLSFDRFAPRFFLATILCATITLENIYSGQLKSMLTFPFYSAPV 485
            |:..::.:.      |:.|....|........|.|.|..|:.|         .::..|......:
Zfish   612 SVWLLWGIVFNNSVPIENPKGTTSKIMVLVWAFFAVIFLASYT---------ANLAAFMIQEQYI 667

  Fly   486 DTIEKWAQSGWKWSAPSIIW----VHTVQSSDLETEQILARNF-EVHDYSYLSNVSFMPNYGFGI 545
            ||:.  ..|..|:..|...:    ..||.:.  .||:.:..|: |:|.:....|..       |:
Zfish   668 DTVS--GLSDKKFQKPQDQYPPFRFGTVPNG--STERNIRSNYPEMHSHMVKYNQK-------GV 721

  Fly   546 E----RLSSGSLSVGDYVSTEALENRIVLHDDLYFDYTRAVSIRGWILMPELNKHIRTCQETGLY 606
            |    .|.:|.|..  ::...|:.|.:...|    :..:.|:|....:.......|...:|:
Zfish   722 EDALNSLKTGKLDA--FIYDAAVLNYMAGKD----EGCKLVTIGSGKVFATTGYGIALQKES--- 777

  Fly   607 FHWE-------LEFIDKYMDKKKQEV-LMDLANGHKVKGAPQALDVRNIAGALFVLAFGVAFAGC 663
             .|:       |:|:.....:|.|.| |..:....|.:.....||:.|:||..::|...:..:..
Zfish   778 -RWKRPIDLALLQFLADGDTQKLQTVWLTGICRNEKKEVMSSKLDIDNMAGVFYMLLVAMGLSLL 841

  Fly   664 ALVAELLIH 672
            ....|.|::
Zfish   842 VFAWEHLLY 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir92a	NP_001097845.2	None
grin2ca	NP_001352716.1	PBP1_iGluR_NMDA_NR2	38..398	CDD:107373	5/16 (31%)
		PBP2_iGluR_NMDA_Nr2	409..810	CDD:270436	88/450 (20%)
		NMDAR2_C	847..>938	CDD:313729	1/4 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591720
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930