DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sirt2 and HST2

DIOPT Version :9

Sequence 1:	NP_001287422.2	Gene:	Sirt2 / 42414	FlyBaseID:	FBgn0038788	Length:	386	Species:	Drosophila melanogaster
Sequence 2:	NP_015310.1	Gene:	HST2 / 856092	SGDID:	S000005936	Length:	357	Species:	Saccharomyces cerevisiae

Alignment Length:	386	Identity:	138/386 - (35%)
Similarity:	193/386 - (50%)	Gaps:	84/386 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 SDAKEEVKVEKVIPDLSFDGFAEHWRVHGFRKIVTMVGAGISTSAGIPDFRSPGSGLYSNLKKYE 113
            |.|..|:.|.|:         |.|.:.:...|::.|||||||||.|||||||||:|||.||.:.:
Yeast     4 STASTEMSVRKI---------AAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLK 59

  Fly   114 LPHPTAIFDLDYFEKNPAPFFALAKELYPGSFIPTPAHYFIRLLNDKGLLQRHYTQNIDTLDRLT 178
            ||:|.|:||:|:|:.:|.||:.||||||||:|.|:..||.::|..||.:|:|.||||||||:|..
Yeast    60 LPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQA 124

  Fly   179 GLPEDKIIEAHGSFHTNHCIKCRKEYDMDWMKAEIFADRLP--------KCQKCQGVVKPDIVFF 235
            |:.:|.||||||||...|||.|.|.|     ..::|..:|.        ||..|..:|||.||||
Yeast   125 GVKDDLIIEAHGSFAHCHCIGCGKVY-----PPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFF 184

  Fly   236 GENLPKRFYSS------------------PEEDFQDCDLLIIMGTSLEVQPFASLVWRPGPRCIR 282
            ||:||..|..:                  |::     .|:|::||||.|.|||||......:..|
Yeast   185 GEDLPDSFSETWLNDSEWLREKITTSGKHPQQ-----PLVIVVGTSLAVYPFASLPEEIPRKVKR 244

  Fly   283 LLINRDAVGQASCVLFMDPNTRSLLFDKPNNTRDVAFLGDCDAGVMALAKALGWDQELQQLITS- 346
            :|.|.:.||.               |.......|:......|.....|.:.|||.::.::::|:
Yeast   245 VLCNLETVGD---------------FKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQ 294

  Fly   347 ----------------ERKKLSGSQNSEELQQGKEKP-------QSDPDKMTSGDRDKKDA 384
                            :.:.||..|:..|....|:|.       .||.|..::....:|.|
Yeast   295 GGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAA 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt2	NP_001287422.2	SIRT1	79..330	CDD:238699	115/276 (42%)
HST2	NP_015310.1	SIRT1	26..277	CDD:238699	115/275 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343035
Domainoid	1	1.000	191	1.000	Domainoid score	I626
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40823
Inparanoid	1	1.050	220	1.000	Inparanoid score	I773
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54280
OrthoFinder	1	1.000	-	-		FOG0000643
OrthoInspector	1	1.000	-	-		oto99144
orthoMCL	1	0.900	-	-		OOG6_101879
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R577
SonicParanoid	1	1.000	-	-		X1602
TreeFam	0	0.000	Not matched by this tool.
	13	12.930