Protein Alignment Sirt2 and HST3

DIOPT Version :9

• Sequence 1: NP_001287422.2
• Gene: Sirt2 / 42414
• FlyBaseID: FBgn0038788
• Length: 386
• Species: Drosophila melanogaster
• Sequence 2: NP_014668.1
• Gene: HST3 / 854190
• SGDID: S000005551
• Length: 447
• Species: Saccharomyces cerevisiae
• Alignment Length: 410
• Identity: 105/410 - (25%)
• Similarity: 158/410 - (38%)
• Gaps: 117/410 - (28%)

  Fly    49 SDAKEEVKVEKVIPDLSFDGFAEHWR-----VHGFRKIVTMVGAGISTSAGIPDFRSPGSGLYSN 108
            ||....::.||:...:..|...|..|     :...|:|..:.|||||.:|||||||| ..|||..
Yeast    18 SDLPSSLQTEKLAHIIGLDADDEVLRRVTKQLSRSRRIACLTGAGISCNAGIPDFRS-SDGLYDL 81

  Fly   109 LKK-----YELPHPTAIFDLDYFEKN--PAPFFALAKELYPGSFI--PTPAHYFIRLLNDKGLLQ 164
            :||     :.:.....:||:..|..:  .:.|....:.||....:  ||..|.||..|.|:..|.
Yeast    82 VKKDCSQYWSIKSGREMFDISLFRDDFKISIFAKFMERLYSNVQLAKPTKTHKFIAHLKDRNKLL 146

  Fly   165 RHYTQNIDTLDRLTGLPEDK----------------IIEAHGSFHTNHCIKCRKEYDMD--WMKA 211
            |.||||||.|:...||....                :::.||...|..|.||.:.:...  |.:.
Yeast   147 RCYTQNIDGLEESIGLTLSNRKLPLTSFSSHWKNLDVVQLHGDLKTLSCTKCFQTFPWSRYWSRC 211

  Fly   212 EIFADRLPKCQKCQ------------------GVVKPDIVFFGENLPKRFYSSPEEDFQDC---- 254
             :....||.|..|:                  |:::|:||.:|||.|            .|
Yeast   212 -LRRGELPLCPDCEALINKRLNEGKRTLGSNVGILRPNIVLYGENHP------------SCEIIT 263

  Fly   255 ------------DLLIIMGTSLEVQPFASLVWRPGPRC-----IRLLINRDAVGQASCVLFMDPN 302
                        |.||||||||:|.....||.:...:.     :.:|:|:..:|::|....:|..
Yeast   264 QGLNLDIIKGNPDFLIIMGTSLKVDGVKQLVKKLSKKIHDRGGLIILVNKTPIGESSWHGIIDYQ 328

  Fly   303 TRSLLFDKPNNTRDVAFLGDCDAGVMALAKAL-----GWDQ--ELQQLITSERKKLSGSQNSEEL 360
            ..|                |||..|..|...:     ..||  :|:||      |...|...:::
Yeast   329 IHS----------------DCDNWVTFLESQIPDFFKTQDQIKKLRQL------KREASDLRKQM 371

  Fly   361 QQGKEK---PQSDPDKMTSG 377
            :..|:.   |.:.|.:...|
Yeast   372 KAQKDSIGTPPTTPLRTAQG 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt2	NP_001287422.2	SIRT1	79..330	CDD:238699	86/316 (27%)
HST3	NP_014668.1	SIR2	42..349	CDD:223915	88/336 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000643
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910