Protein Alignment Sirt2 and HST1

DIOPT Version :9

• Sequence 1: NP_001287422.2
• Gene: Sirt2 / 42414
• FlyBaseID: FBgn0038788
• Length: 386
• Species: Drosophila melanogaster
• Sequence 2: NP_014573.1
• Gene: HST1 / 854086
• SGDID: S000005429
• Length: 503
• Species: Saccharomyces cerevisiae
• Alignment Length: 422
• Identity: 127/422 - (30%)
• Similarity: 187/422 - (44%)
• Gaps: 101/422 - (23%)

  Fly     3 DIEVKKEEQPTTPSNSSSSDDDEEAPDDTMDKVRRFFANTLHLGGSSDAKEEVK--------VEK 59
            :|...||......|:..:..:||:...|.::|                 |..||        :.|
Yeast   129 NITSNKERSSAELSSIHAKAEDEDELTDPLEK-----------------KHAVKLIKDLQKAINK 176

  Fly    60 V------IPDL-SFDGFAEHWRVHGFRKIVTMVGAGISTSAGIPDFRSPGSGLYSNLKKYELPHP 117
            |      :|:. :.|.|....|  ..:||:.:.|||:|||.||||||| ..|.||.::...|..|
Yeast   177 VLSTRLRLPNFNTIDHFTATLR--NAKKILVLTGAGVSTSLGIPDFRS-SEGFYSKIRHLGLEDP 238

  Fly   118 TAIFDLDYFEKNPAPFFALAKELYPGSFIPTPAHYFIRLLNDKGLLQRHYTQNIDTLDRLTGLPE 182
            ..:|:||.|.::|:.|:.:|..:.|...:.:|.|.||::|.|||.|.|:||||||.|:...|:..
Yeast   239 QDVFNLDIFLQDPSVFYNIAHMVLPPENMYSPLHSFIKMLQDKGKLLRNYTQNIDNLESYAGIDP 303

  Fly   183 DKIIEAHGSFHTNHCIKCRKEYDMDWMKAEIFADRLPKCQKC----------------------- 224
            ||:::.||||.|..|:.|..:...:.:...|....||.|..|
Yeast   304 DKLVQCHGSFATASCVTCHWQIPGEKIFENIRNLELPLCPYCYQKRKQYFPMSNGNNTVQTNINF 368

  Fly   225 -------QGVVKPDIVFFGENLPKRFYSSPEEDFQDCDLLIIMGTSLEVQPFASLVWRPGPRCIR 282
                   .||:|||:.||||.||.||:.:..:|..:|||||.:||||:|.|.:.:|........:
Yeast   369 NSPILKSYGVLKPDMTFFGEALPSRFHKTIRKDILECDLLICIGTSLKVAPVSEIVNMVPSHVPQ 433

  Fly   283 LLINRDAVGQASCVLFMDPNTRSLLFDKPNNTRDVAFLGDCDAGVMALAKALGWD------QELQ 341
            :|||||.|..|..                    |:..||.||.....:||...||      |:|:
Yeast   434 ILINRDMVTHAEF--------------------DLNLLGFCDDVASLVAKKCHWDIPHKKWQDLK 478

  Fly   342 QLITSERKKLSGSQNSEELQQGKEKPQSDPDK 373
            ::          ..|..|:.:|..|.:..|.|
Yeast   479 KI----------DYNCTEIDKGTYKIKKQPRK 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt2	NP_001287422.2	SIRT1	79..330	CDD:238699	98/280 (35%)
HST1	NP_014573.1	DUF592	53..207	CDD:368003	19/96 (20%)
		SIRT1	201..461	CDD:238699	98/280 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000643
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R577
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940