Protein Alignment Sirt2 and SIR2

DIOPT Version :10

• Sequence 1: NP_650880.3
• Gene: Sirt2 / 42414
• FlyBaseID: FBgn0038788
• Length: 386
• Species: Drosophila melanogaster
• Sequence 2: NP_010242.1
• Gene: SIR2 / 851520
• SGDID: S000002200
• Length: 562
• Species: Saccharomyces cerevisiae
• Alignment Length: 337
• Identity: 113/337 - (33%)
• Similarity: 162/337 - (48%)
• Gaps: 66/337 - (19%)

  Fly    65 SFDGFAEHWRVHGFRKIVTMVGAGISTSAGIPDFRSPGSGLYSNLKKYELPHPTAIFDLDYFEKN 129
            :.|.|.:  ::|..|||:.:.|||:|||.||||||| ..|.||.:|...|..|..:|:.:.|..:
Yeast   243 TIDHFIQ--KLHTARKILVLTGAGVSTSLGIPDFRS-SEGFYSKIKHLGLDDPQDVFNYNIFMHD 304

  Fly   130 PAPFFALAKELYPGSFIPTPAHYFIRLLNDKGLLQRHYTQNIDTLDRLTGLPEDKIIEAHGSFHT 194
            |:.|:.:|..:.|...|.:|.|.||::|..||.|.|:||||||.|:...|:..||:::.||||.|
Yeast   305 PSVFYNIANMVLPPEKIYSPLHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKLVQCHGSFAT 369

  Fly   195 NHCIKC---------------------------RKEYDMDWMKAEI--------FADRLPKCQKC 224
            ..|:.|                           |:||..:....::        .::|.|.....
Yeast   370 ATCVTCHWNLPGERIFNKIRNLELPLCPYCYKKRREYFPEGYNNKVGVAASQGSMSERPPYILNS 434

  Fly   225 QGVVKPDIVFFGENLPKRFYSSPEEDFQDCDLLIIMGTSLEVQPFASLVWRPGPRCIRLLINRDA 289
            .||:||||.||||.||.:|:.|..||..:|||||.:||||:|.|.:.:|........::|||||.
Yeast   435 YGVLKPDITFFGEALPNKFHKSIREDILECDLLICIGTSLKVAPVSEIVNMVPSHVPQVLINRDP 499

  Fly   290 VGQASCVLFMDPNTRSLLFDKPNNTRDVAFLGDCDAGVMALAKALGWDQELQQLITSERKKLSGS 354
            |..|..                    |::.||.||.....:|:..||        |...||.:..
Yeast   500 VKHAEF--------------------DLSLLGYCDDIAAMVAQKCGW--------TIPHKKWNDL 536

  Fly   355 QNSEELQQGKEK 366
            :|.....|.|:|
Yeast   537 KNKNFKCQEKDK 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt2	NP_650880.3	SIRT1	79..330	CDD:238699	100/285 (35%)
SIR2	NP_010242.1	DUF592	104..261	CDD:368003	6/19 (32%)
		SIRT1	255..517	CDD:238699	100/282 (35%)