Protein Alignment Sirt2 and sirt1

DIOPT Version :10

• Sequence 1: NP_650880.3
• Gene: Sirt2 / 42414
• FlyBaseID: FBgn0038788
• Length: 386
• Species: Drosophila melanogaster
• Sequence 2: XP_001334440.5
• Gene: sirt1 / 797132
• ZFINID: ZDB-GENE-070801-2
• Length: 742
• Species: Danio rerio
• Alignment Length: 334
• Identity: 131/334 - (39%)
• Similarity: 184/334 - (55%)
• Gaps: 68/334 - (20%)

  Fly    79 RKIVTMVGAGISTSAGIPDFRSPGSGLYSNLKK--YELPHPTAIFDLDYFEKNPAPFFALAKELY 141
            :||:.:.|||:|.|.||||||| ..|:|:.|..  .:||.|.|:||:|||.::|.|||..|||:|
Zfish   190 KKILVLTGAGVSVSCGIPDFRS-RDGIYARLAVDFPDLPDPQAMFDIDYFRRDPRPFFKFAKEIY 253

  Fly   142 PGSFIPTPAHYFIRLLNDKGLLQRHYTQNIDTLDRLTGLPEDKIIEAHGSFHTNHCIKCRKEYDM 206
            ||.|.|:|.|.||.:|:.||.|.|:||||||||:::.|:  .|||:.||||.|..|:.|:.:.|.
Zfish   254 PGQFQPSPCHRFISMLDKKGRLLRNYTQNIDTLEQVAGI--QKIIQCHGSFATASCLICKHKVDC 316

  Fly   207 DWMKAEIFADRLPKCQKC-----QGVVKPDIVFFGENLPKRFYSSPEEDFQDCDLLIIMGTSLEV 266
            :.::.:||...:|.|.:|     ..::||||||||||||:.|:.:.::|..:.||||::|:||:|
Zfish   317 EAIREDIFNQVVPHCPRCPSDVPYAIMKPDIVFFGENLPEFFHRAMKQDKDEVDLLIVIGSSLKV 381

  Fly   267 QPFASLVWRPGPRCI-----RLLINRDAVGQASCVLFMDPNTRSLLFDKPNNTRDVAFLGDCDAG 326
            :|.|.:     |..|     ::||||:.:                    |:...||..|||||..
Zfish   382 RPVALI-----PSSIPHDVPQVLINREPL--------------------PHLNFDVELLGDCDVI 421

  Fly   327 VMALAKALGWDQELQQLITSERKKLSGSQNSEELQQGKEKP--------------QSDPDKM--T 375
            |..|...|..|  .|||          ..||..|.:..|||              .:|.:.:  |
Zfish   422 VNELCHRLNGD--FQQL----------CYNSSRLSEITEKPAAPEHTENTSADHSHADAEHIENT 474

  Fly   376 SGDRDKKDA 384
            |.|||..||
Zfish   475 SADRDDADA 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt2	NP_650880.3	SIRT1	79..330	CDD:238699	111/262 (42%)
sirt1	XP_001334440.5	None